公开(公告)号：WO2021150858A1

公开(公告)日：2021-07-29

申请号：PCT/US2021/014561

申请日：2021-01-22

Applicant: SPIRAL THERAPEUTICS INC.

Inventor： DE JUAN, Eugene ,  ERICKSON, Signe ,  LIMB, Charles ,  PERIS, Hugo ,  TALREJA, Nikhil ,  AYOOB, Andrew

IPC: A61F11/00 ,  A61B1/018 ,  A61B1/227 ,  A61B17/29 ,  A61B17/320068 ,  A61B17/3205 ,  A61B17/3423 ,  A61B17/3468 ,  A61B17/3478 ,  A61B18/04 ,  A61B18/1485 ,  A61B18/20 ,  A61B2017/00115 ,  A61B2017/00787 ,  A61B2017/00867 ,  A61B2017/32007 ,  A61B2018/00327 ,  A61B2217/005 ,  A61F11/002 ,  A61F11/004 ,  A61F2/958 ,  A61F2002/183 ,  A61F2250/0067 ,  A61M2037/0023 ,  A61M2037/0046 ,  A61M2205/04 ,  A61M2210/0662 ,  A61M2210/0668 ,  A61M31/00 ,  A61M31/002 ,  A61M37/0015 ,  G02B21/0012 ,  G02B21/0032 ,  G02B21/22

Abstract: Intra-tympanic injections of therapeutics into the inner ear can be used to treat conditions such as hearing loss. One or more stabilizing devices that define working channels can be temporarily implanted in the tympanic membrane. Purpose-built instruments such as endoscopes, forceps, and injections instruments can be passed through the working channels of the stabilizer devices to access the inner ear where the therapy can be administered. Afterwards, the stabilizing devices can be removed from the tympanic membrane and the tympanic membrane can heal, typically without the need for sutures.

公开(公告)号：WO2021150894A2

公开(公告)日：2021-07-29

申请号：PCT/US2021/014618

申请日：2021-01-22

Applicant: SPIRAL THERAPEUTICS INC.

Inventor： DE JUAN, Eugene ,  ERICKSON, Signe ,  LIMB, Charles ,  PERIS, Hugo ,  AYOOB, Andrew ,  LEVERING, Vrad

IPC: A61F11/00 ,  A61F2/18 ,  A61B1/018 ,  A61B1/227 ,  A61B17/29 ,  A61B17/320068 ,  A61B17/3205 ,  A61B17/3423 ,  A61B17/3468 ,  A61B17/3478 ,  A61B18/04 ,  A61B18/1485 ,  A61B18/20 ,  A61B2017/00115 ,  A61B2017/00323 ,  A61B2017/00331 ,  A61B2017/00787 ,  A61B2017/00867 ,  A61B2017/32007 ,  A61B2017/345 ,  A61B2018/00327 ,  A61B2217/005 ,  A61F11/002 ,  A61F11/004 ,  A61F2/958 ,  A61F2002/183 ,  A61F2250/0067 ,  A61M2037/0023 ,  A61M2037/0046 ,  A61M2205/04 ,  A61M2210/0662 ,  A61M2210/0668 ,  A61M31/00 ,  A61M31/002 ,  A61M37/0015 ,  G02B21/0012 ,  G02B21/0032 ,  G02B21/22

Abstract: Systems and methods can be employed for trans-tympanic membrane access to the middle ear for delivery of a therapeutic agent, for example, to the round window niche adjacent to the cochlea under direct visualization. The systems and methods can also be used to improve accessibility and visualization for various otological surgical procedures, such as, but not limited to, cholesteatoma removal, tympanic membrane repair and ossicular chain repair.

公开(公告)号：WO2020176419A1

公开(公告)日：2020-09-03

申请号：PCT/US2020/019517

申请日：2020-02-24

Applicant: SPIRAL THERAPEUTICS, INC.

Inventor： SACHERMAN, Kevin W. ,  AYOOB, Andrew ,  ERICKSON, Signe ,  PERIS, Hugo ,  LIMB, Charles ,  DE JUAN, Jr., Eugene

IPC: A61M5/32 ,  A61B1/227 ,  A61F11/00

Abstract: A system for delivering one or more therapeutics to a region of the ear, the region being internal to a tympanic membrane. The system includes a canal guide configured to be inserted within and fittingly engaged with walls of the ear canal and needle assembly having a flexible shaft sized to extend through the canal guide. The canal guide provides alignment of the needle assembly within the ear canal relative to the tympanic membrane. The canal guide includes a viewing lumen extending between a proximal end to a distal-most end of the canal guide and is sized to remain external to the tympanic membrane. The canal guide includes a guide lumen extending to a distal opening near the distal-most end of the canal guide. The guide lumen curves from a first axis to a second axis. Related devices, systems, and methods are provided.

公开(公告)号：WO2021150881A1

公开(公告)日：2021-07-29

申请号：PCT/US2021/014601

申请日：2021-01-22

Applicant: SPIRAL THERAPEUTICS INC.

Inventor： DE JUAN, Eugene ,  ERICKSON, Signe ,  LIMB, Charles ,  LEVERING, Vrad

IPC: A61F11/00 ,  A61B1/018 ,  A61B1/227 ,  A61B17/29 ,  A61B17/320068 ,  A61B17/3205 ,  A61B17/3423 ,  A61B17/3468 ,  A61B17/3478 ,  A61B18/04 ,  A61B18/1485 ,  A61B18/20 ,  A61B2017/00115 ,  A61B2017/00787 ,  A61B2017/00867 ,  A61B2017/32007 ,  A61B2018/00327 ,  A61B2217/005 ,  A61F11/002 ,  A61F11/004 ,  A61F2/958 ,  A61F2002/183 ,  A61F2250/0067 ,  A61M2037/0023 ,  A61M2037/0046 ,  A61M2205/04 ,  A61M2210/0662 ,  A61M2210/0668 ,  A61M31/00 ,  A61M31/002 ,  A61M37/0015 ,  G02B21/0012 ,  G02B21/0032 ,  G02B21/22

Abstract: Systems and methods can be employed for facilitating access and procedures in the outer, middle, and inner ear in order to diagnose or treat ear disorders including, but not limited to hearing loss and excessive ear wax. In some examples, the systems and methods include instruments and techniques that facilitate trans-tympanic membrane or trans-fibrous ring access to the middle ear. The systems and methods can also be used to improve accessibility for various otological surgical procedures, such as, but not limited to, cholesteatoma removal, tympanic membrane repair and ossicular chain repair.