公开(公告)号：WO2009131245A1

公开(公告)日：2009-10-29

申请号：PCT/JP2009/058434

申请日：2009-04-22

Applicant: TAKEDA PHARMACEUTICAL COMPANY LIMITED ,  YOSHIDA, Masato ,  SAKAUCHI, Nobuki ,  SATO, Ayumu

Inventor： YOSHIDA, Masato ,  SAKAUCHI, Nobuki ,  SATO, Ayumu

IPC: C07D213/82 ,  A61K31/44 ,  A61P13/02

CPC classification number: C07D213/82

Abstract: The present invention aims to provide an iminopyridine derivative compound having an α1D adrenergic receptor antagonistic action, which is useful as an agent for the prophylaxis or treatment of a lower urinary tract disease and the like.The present invention provides a compound represented by the formula wherein each symbol is as defined in the specification, or a salt thereof.

Abstract translation: 本发明的目的在于提供具有a1D肾上腺素能受体拮抗作用的亚氨基吡啶衍生物化合物，其可用作预防或治疗下尿路疾病等。本发明提供下式表示的化合物，其中 每个符号如说明书中所定义，或其盐。

公开(公告)号：WO2019027054A1

公开(公告)日：2019-02-07

申请号：PCT/JP2018/029321

申请日：2018-07-30

Applicant: TAKEDA PHARMACEUTICAL COMPANY LIMITED

Inventor： ITO, Masahiro ,  SUGIYAMA, Hideyuki ,  KUBO, Osamu ,  KIKUCHI, Fumiaki ,  YASUI, Takeshi ,  KAKEGAWA, Keiko ,  IKEDA, Zenichi ,  MIYAZAKI, Tohru ,  ARIKAWA, Yasuyoshi ,  OKAWA, Tomohiro ,  YONEMORI, Jinichi ,  TOITA, Akinori ,  KOJIMA, Takuto ,  ASANO, Yasutomi ,  SATO, Ayumu ,  MAEZAKI, Hironobu ,  SASAKI, Shinobu ,  KOKUBO, Hironori ,  HOMMA, Misaki ,  SASAKI, Minoru ,  IMAEDA, Yasuhiro

IPC: C07D413/14 ,  C07D413/04 ,  C07D417/14 ,  C07D487/04 ,  A61K31/4245 ,  A61K31/454 ,  A61K31/513 ,  A61K31/5377 ,  A61P25/28

Abstract: The present invention provides a heterocyclic compound having a HDAC inhibitory action, and useful for the treatment of central nervous system diseases including neurodegenerative disease, and the like, and a medicament comprising the compound. The present invention relates to a compound represented by the formula (I) wherein each symbol is as defined in the specification, or a salt thereof.

公开(公告)号：WO2018030550A1

公开(公告)日：2018-02-15

申请号：PCT/JP2017/029695

申请日：2017-08-08

Applicant: TAKEDA PHARMACEUTICAL COMPANY LIMITED

Inventor： YAMAMOTO, Satoshi ,  SHIRAI, Junya ,  KONO, Mitsunori ,  SHIOKAWA, Zenyu ,  YUKAWA, Tomoya ,  IMADA, Takashi ,  NEGORO, Nobuyuki ,  ODA, Tsuneo ,  SASAKI, Satoshi ,  NARA, Yoshi ,  SUZUKI, Shinkichi ,  SATO, Ayumu ,  ISHII, Naoki ,  SHIBUYA, Akito ,  NAKAGAWA, Yasuo ,  COLE, Derek ,  GIBSON, Tony ,  IVETAC, Anthony ,  SWANN, Steve ,  TYHONAS, John

IPC: C07D401/14 ,  C07D215/06 ,  C07D311/44 ,  C07D311/68 ,  C07D401/06 ,  C07D401/12 ,  C07D405/04 ,  C07D405/06 ,  C07D413/04 ,  C07D413/10 ,  C07D413/12 ,  C07D417/04 ,  C07D471/04 ,  C07D265/36 ,  C07D498/04 ,  A61K31/352 ,  A61K31/353 ,  A61K31/4353 ,  A61K31/47 ,  A61K31/536 ,  A61P35/00

Abstract: The present invention relates to a compound that may have an ROR(gamma)t modulating activity and can thus be useful in the treatment of cancer.

Abstract translation: 本发明涉及可具有ROR（γ）t调节活性并因此可用于治疗癌症的化合物。