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    ISOFORMS OF ELF-5A: SENESCENCE-INDUCED ELF5A; WOUNDING-INDUCED ELF-5A; GROWTH ELF-5A; AND DHS
    1.
    发明申请
    ISOFORMS OF ELF-5A: SENESCENCE-INDUCED ELF5A; WOUNDING-INDUCED ELF-5A; GROWTH ELF-5A; AND DHS 审中-公开
    ELF-5A的ISOFORMS：敏感性ELF5A; 绕线诱导型ELF-5A; 生长ELF-5A; 和DHS

    公开(公告)号：WO2004113528A2

    公开(公告)日：2004-12-29

    申请号：PCT/US2004/019840

    申请日：2004-06-21

    Applicant: SENESCO TECHNOLOGIES, INC. ,  THOMPSON, John, E.

    Inventor： THOMPSON, John, E.

    IPC: C12N15/00

    CPC classification number: C07K14/4705 ,  C07K14/415 ,  C12N9/0004 ,  C12N15/8249 ,  C12N15/8266 ,  C12N15/8271

    Abstract: The present invention relates to unique isoforms of eukaryotic initiation Factor 5A ("eIF-5A"): senescence-induced eIF-5A; wounding-induced eIF-5A; and growth eIF-5A, as well as polynucleotides that encode these three factors. The present invention also relates to methods involving modulating the expression of these factors. The present invention also relates to deoxyhypusine synthase ("DHS"), polynucleotides that encode DHS, and methods involving modulating the expression of DHS.

    Abstract translation: 本发明涉及真核起始因子5A（“eIF-5A”）的独特同工型：衰老诱导的eIF-5A; 伤员诱导的eIF-5A; 和生长eIF-5A，以及编码这三个因子的多核苷酸。 本发明还涉及涉及调节这些因子的表达的方法。 本发明还涉及脱氧螺旋体合成酶（“DHS”），编码DHS的多核苷酸以及涉及调节DHS表达的方法。

    CONTROL OF SENESCENCE IN FRUITS, VEGETABLES AND FLOWERS
    3.
    发明申请
    CONTROL OF SENESCENCE IN FRUITS, VEGETABLES AND FLOWERS 审中-公开
    水果，蔬菜和花卉中的敏感控制

    公开(公告)号：WO1988002602A1

    公开(公告)日：1988-04-21

    申请号：PCT/US1987002557

    申请日：1987-10-08

    Applicant: DUMBROFF, Erwin, B. ,  THOMPSON, John, E. ,  SHIH, Ching, Yu ,  STEWART, Michael, Ian

    IPC: A23B07/00

    CPC classification number: A01N37/38 ,  A01N43/16 ,  A23B7/10 ,  A23B7/154 ,  A23B7/16

    Abstract: Senescence in perishable plant tissue is inhibited by the application thereto of an effective amount of a compound of formula (I), wherein R1, R2, R3, R4 and R5 are each selected from the group consisting of hydrogen, -OH or -OR7, provided that at least one of R1 to R5 is a hydroxyl group, R6 is selected from the group consisting of -OH, -OR8 and -NHR9, R7 is a substituent group, R8 is the residue of an ester-forming compound and R9 is the residue of an amide-forming compound. The compound may be prepared synthetically and, in some cases, can be isolated from natural sources, for example, the glucose ester of ferulic acid may be isolated from carnation petals.

    Abstract translation: 通过施用有效量的式（I）化合物，其中R 1，R 2，R 3，R 4和R 5各自选自氢，-OH或-OR 7，可以抑制易腐植物组织中的衰老， 条件是R 1至R 5中的至少一个为羟基，R 6选自-OH，-OR 8和-NHR 9，R 7为取代基，R 8为酯形成化合物的残基，R 9为 酰胺形成化合物的残基。 化合物可以合成制备，并且在一些情况下可以从天然来源分离，例如，阿魏酸的葡萄糖酯可以从康乃馨花瓣中分离出来。

    INHIBITION OF APOPTOSIS-SPECIFIC ELF-5A (“EIF-5A1”) WITH ANTISENSE OLIGONUCLEOTIDES AND SIRNAS AS ANTI-INFLAMMATORY THERAPEUTICS
    9.
    发明申请
    INHIBITION OF APOPTOSIS-SPECIFIC ELF-5A (“EIF-5A1”) WITH ANTISENSE OLIGONUCLEOTIDES AND SIRNAS AS ANTI-INFLAMMATORY THERAPEUTICS 审中-公开
    抗生素ELF-5A（“EIF-5A1”）与抗炎寡核苷酸和SIRNAS作为抗炎治疗药物的抑制作用

    公开(公告)号：WO2005007853A2

    公开(公告)日：2005-01-27

    申请号：PCT/US2004/018012

    申请日：2004-06-07

    Applicant: SENESCO TECHNOLOGIES, INC. ,  THOMPSON, John, E. ,  TAYLOR, Catherine

    Inventor： THOMPSON, John, E. ,  TAYLOR, Catherine

    IPC: C12N15/11

    CPC classification number: C12N15/113 ,  A61K38/00 ,  C12N2310/11 ,  C12N2310/111 ,  C12N2310/14 ,  C12N2310/53

    Abstract: The present invention relates to apoptosis specific eucaryotic initiation factor 5A (eIF-5A), referred to as apoptosis-specific eIF-5A or eIF5A1, nucleic acids and polypeptides and methods for inhibiting or suppressing apoptosis in cells using antisense nucleotides or siRNAs to inhibit expression of apoptosis-specific eIF-5A. The invention also relates to suppressing or inhibiting expression of pro-inflammatory cytokines or inhibiting expression of pro-inflammatory cytokines or inhibiting activation of NFkB by inhibiting expression of apoptosis-specific eIF-5A.

    Abstract translation: 本发明涉及凋亡特异性真核起始因子5A（eIF-5A），称为凋亡特异性eIF-5A或eIF5A1，核酸和多肽，以及使用反义核苷酸或siRNA抑制或抑制细胞凋亡以抑制表达的方法 的凋亡特异性eIF-5A。 本发明还涉及通过抑制凋亡特异性eIF-5A的表达来抑制或抑制促炎细胞因子的表达或抑制促炎细胞因子的表达或抑制NFkB的活化。

    USE OF ANTISENSE OLIGONUCLEOTIDES OR siRNA TO SUPPRESS EXPRESSION OF eIF-5A1
    10.
    发明申请
    USE OF ANTISENSE OLIGONUCLEOTIDES OR siRNA TO SUPPRESS EXPRESSION OF eIF-5A1 审中-公开
    使用反义寡核苷酸或siRNA抑制eIF-5A1的表达

    公开(公告)号：WO2004078940A2

    公开(公告)日：2004-09-16

    申请号：PCT/US2004/006598

    申请日：2004-03-05

    Applicant: SENESCO TECHNOLOGIES, INC. ,  THOMPSON, John, E. ,  TAYLOR, Catherine

    Inventor： THOMPSON, John, E. ,  TAYLOR, Catherine

    IPC: C12N

    CPC classification number: C12N15/113 ,  A61K31/7088 ,  C12N2310/11 ,  C12N2310/14 ,  C12N2310/53

    Abstract: The present invention relates to apoptosis specific eucaryotic initiation factor 5A (eIF-5A), referred to as apoptosis factor 5A1 or simply factor 5A1, apoptosis factor 5A1 nucleic acids and polypeptides and methods for inhibiting or suppressing apoptosis in cells using antisense nucleotides or siRNAs to inhibit expression of factor 5A1. The invention also relates to suppressing or inhibiting expression of pro-inflammatory cytokines by inhibiting expression of apoptosis factor 5A.

    Abstract translation: 本发明涉及编程性细胞死亡特异性真核细胞启动因子5A（eIF-5A），称为细胞凋亡因子5A1或简单因子5A1，细胞凋亡因子5A1核酸和多肽以及用于抑制或抑制细胞凋亡的方法 在使用反义核苷酸或siRNA的细胞中抑制因子5A1的表达。 本发明还涉及通过抑制凋亡因子5A的表达来抑制或抑制促炎细胞因子的表达。

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