公开(公告)号：WO2016029159A2

公开(公告)日：2016-02-25

申请号：PCT/US2015/046378

申请日：2015-08-21

Applicant: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA

Inventor： EDGERTON, Victor R. ,  GAD, Parag ,  ROY, Roland R. ,  GERASIMENKO, Yury P. ,  LU, Daniel C. ,  ZHONG, Hui

IPC: A61N1/05

CPC classification number: A61N1/36007 ,  A61H3/00 ,  A61K31/475 ,  A61K31/496 ,  A61K31/506 ,  A61K45/06 ,  A61N1/36014 ,  A61N1/3606 ,  A61N1/36071 ,  A61N1/36157 ,  A61N1/36171 ,  A61N1/36175 ,  A63B21/06 ,  A63B22/02 ,  A61K2300/00

公开(公告)号：WO2017024276A1

公开(公告)日：2017-02-09

申请号：PCT/US2016/045898

申请日：2016-08-05

Applicant: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA

Inventor： CHANG, Chih-Wei ,  EDGERTON, Victor Reggie ,  LIU, Wentai ,  GERASIMENKO, Yuri ,  GAD, Parag ,  LO, Yi-Kai

IPC: A61N1/05 ,  A61N1/04 ,  A61N1/36 ,  A61L31/02 ,  A61N1/08

CPC classification number: A61N1/0456 ,  A61N1/0502

Abstract: In various embodiments, a transcutaneous needle electrode and uses thereof are provided. In certain embodiments the needle electrodes comprise a plurality of electrically conductive needles, where the needles are solid, or where the needles are hollow and have a closed tip, where the needles have an average tip diameter less than about 10 µm and an average length greater than about 20-50 µm wherein the electrically conductive needles are electrically coupled to one or more electrical leads.

Abstract translation: 在各种实施方案中，提供经皮针电极及其用途。 在某些实施例中，针电极包括多个导电针，其中针是实心的，或者针是中空的并且具有封闭的尖端，其中针的平均尖端直径小于约10μm，平均长度更大 大约20-50μm，其中导电针电耦合到一个或多个电引线。

公开(公告)号：WO2016033369A1

公开(公告)日：2016-03-03

申请号：PCT/US2015/047268

申请日：2015-08-27

Applicant: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA

Inventor： LIU, Wentai ,  EDGERTON, Victor Reggie ,  CHANG, Chih-Wei ,  GAD, Parag

IPC: A61N1/04 ,  A61N1/05

CPC classification number: A61N1/0553 ,  A61N1/0476 ,  A61N1/0551 ,  A61N1/0558 ,  A61N1/36007 ,  A61N1/36067 ,  A61N1/36071 ,  A61N1/36082 ,  A61N1/36107 ,  A61N1/3611 ,  A61N1/36114

Abstract: In certain embodiments an electrode array for epidural stimulation of the spinal cord is provided where the array comprises a plurality of electrodes disposed on a flexible polymer substrate; said electrodes being electrically connected to one or more lead wires and/or connection points on an electrical connector; where the electrodes of said array are bonded to said polymer so that the electrodes can carry an electrical stimulation signal having a voltage, frequency, and current sufficient to provide epidural stimulation of a spinal cord and/or brain in vivo or in a physiological saline solution, without separation of all or a part of an electrode from the polymer substrate.

Abstract translation: 在某些实施例中，提供了用于脊髓硬膜外刺激的电极阵列，其中所述阵列包括设置在柔性聚合物基底上的多个电极; 所述电极电连接到电连接器上的一个或多个引线和/或连接点; 其中所述阵列的电极结合到所述聚合物，使得电极可以携带具有足以在体内或生理盐水溶液中提供对脊髓和/或脑的硬膜外刺激的电压，频率和电流的电刺激信号 ，而不将电极的全部或一部分与聚合物基底分离。

公开(公告)号：WO2020236946A1

公开(公告)日：2020-11-26

申请号：PCT/US2020/033830

申请日：2020-05-20

Applicant: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA ,  SCUOLA INTERNAZIONALE SUPERIORE DI STUDI AVANZATI - SISSA ,  UNIVERSITY OF SOUTHERN CALIFORNIA

Inventor： GAD, Parag ,  EDGERTON, Victor Reggie ,  TACCOLA, Giuliano ,  KREYDIN, Evgenily I.

IPC: A61N1/18 ,  A61N1/36 ,  A47K13/00

Abstract: In various embodiments electrical stimulators are provided for transcutaneous and/or epidural stimulation. In certain embodiments the stimulator provides one or more channels configured to provide one or more of the following stimulation patterns: i) monophasic electrical stimulation with a DC offset; ii) monophasic electrical stimulation with charge balance; iii) delayed biphasic electrical stimulation with a DC offset; iv) delayed biphasic electrical stimulation with charge balance; v) amplitude modulated dynamic stimulation; and/or vi) frequency modulated dynamic stimulation.

公开(公告)号：WO2017035512A1

公开(公告)日：2017-03-02

申请号：PCT/US2016/049129

申请日：2016-08-26

Applicant: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA

Inventor： EDGERTON, Victor, R. ,  GERASIMENKO, Yuri, P. ,  GAD, Parag

IPC: A61N1/36 ,  A61N1/04 ,  A61N1/05 ,  B25J9/00 ,  B25J13/02 ,  B25J11/00

CPC classification number: A61N1/0476 ,  A61F5/01 ,  A61G5/14 ,  A61H1/024 ,  A61H1/0244 ,  A61H1/0277 ,  A61H1/0281 ,  A61H3/00 ,  A61H3/02 ,  A61H2201/10 ,  A61H2201/1207 ,  A61H2201/1614 ,  A61H2201/1623 ,  A61H2201/1628 ,  A61H2201/1635 ,  A61H2201/164 ,  A61H2201/165 ,  A61H2201/50 ,  A61H2201/5025 ,  A61H2201/5061 ,  A61H2201/5064 ,  A61N1/0408 ,  A61N1/0484 ,  A61N1/36003 ,  A61N1/36031 ,  A61N1/36034 ,  A61N1/36057

Abstract: In various embodiments a method of synergistically using a neuromodulation stimulator and a robotic exoskeleton for the restoration of voluntary movement and greater muscle activation in chronically paralyzed subjects is provided. The noninvasive neuromodulation system delivers signals to facilitate the restoration and/or enhancement of neurological function where at least one effect is strengthened stepping capacity that can be further substantiated when coupled with robotic exoskeleton assistance.

Abstract translation: 在各种实施例中，提供了协同使用神经调节刺激器和机器人外骨骼来恢复长期瘫痪的受试者中的自愿运动和更大的肌肉激活的方法。 非侵入性神经调节系统提供信号以促进神经功能的恢复和/或增强，其中至少一种效应被加强，当与机器人外骨骼辅助相结合时可以进一步证实这种功能。