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    IMPROVEMENTS IN OR RELATING TO AN APPARATUS FOR DETECTION AND ANALYSIS OF A COMPONENT
    1.
    发明申请
    IMPROVEMENTS IN OR RELATING TO AN APPARATUS FOR DETECTION AND ANALYSIS OF A COMPONENT 审中-公开

    公开(公告)号：WO2022008933A1

    公开(公告)日：2022-01-13

    申请号：PCT/GB2021/051771

    申请日：2021-07-09

    Applicant: VIDYA HOLDINGS LTD

    Inventor： DORRESTIJN, Marko ,  KLUG, David R. ,  TUREK, Vladimir ,  WORKUM, Stefan Leo Van

    IPC: G01N21/64 ,  G01N21/65 ,  G01N21/76 ,  G01N33/543 ,  G01N21/51

    Abstract: An apparatus for creating and correcting a two dimensional intensity map of one or more assay spots in a detection zone is provided. The apparatus comprising, a locator for affirming the location of the detection zone; a total internal reflection excitation device comprising a light source for illuminating the one or more assay spots in the detection zone; a detector configured to receive light that is emitted, reflected or scattered from the one or more assay spots and to create a two dimensional intensity map of the one or more assay spots comprising a two dimensional array of quantitative pixel values; and a processor configured to correct the intensity map to remove noise through analysis of corresponding pixel values from an earlier intensity map; wherein the analysis includes curve fitting.

    IMPROVEMENTS IN OR RELATING TO AN OPTICAL ELEMENT
    2.
    发明申请
    IMPROVEMENTS IN OR RELATING TO AN OPTICAL ELEMENT 审中-公开

    公开(公告)号：WO2020178564A1

    公开(公告)日：2020-09-10

    申请号：PCT/GB2020/050486

    申请日：2020-02-28

    Applicant: VIDYA HOLDINGS LTD

    Inventor： VAN WORKUM, Stefan Leo ,  SMITH, Callum Robertson ,  DORRESTIJN, Marko ,  KLUG, David

    IPC: A61B5/151 ,  C03B23/047 ,  G01N21/64 ,  G01N33/543

    Abstract: An assay cartridge for detecting a target component in a fluid is provided. The assay cartridge including an optical element comprising: a light pathway comprising an input surface, reflective surface and output surface configured to enable light to enter, reflect and create an evanescent field in the vicinity of the reflective surface and exit the element;a plurality of capture components deposited on the reflective surface in the vicinity of the evanescent field; and a transmission surface configured to enable emissions from the evanescent field to exit the element; wherein the assay cartridge is a single use cartridge.

    IMPROVEMENTS IN OR RELATING TO A DEVICE FOR ANALYSING A SAMPLE
    5.
    发明申请
    IMPROVEMENTS IN OR RELATING TO A DEVICE FOR ANALYSING A SAMPLE 审中-公开

    公开(公告)号：WO2022038374A1

    公开(公告)日：2022-02-24

    申请号：PCT/GB2021/052169

    申请日：2021-08-20

    Applicant: VIDYA HOLDINGS LTD

    Inventor： DORRESTIJN, Marko ,  KLUG, David Rupert ,  TUREK, Vladimir ,  VAN WORKUM, Stefan Leo

    IPC: B01L3/00

    Abstract: A lateral to free flow assay device is provided for analysis of a fluid sample. The device comprises: a sample collection unit configured to introduce the sample into the device; an optical element configured to facilitate TIR for the analysis of the sample; a fluid pathway configured to provide fluid communication between the sample collection unit and a free flow region adjacent the optical element; a wicking pad defining a lateral flow section of the fluid pathway or provided in the sample collection unit to collect the sample; wherein at least one surface of the optical element defines at least part of the free flow region of the fluid pathway; and wherein the fluid pathway is configured to enable fluid flow from the lateral flow region to the free flow region of the fluid pathway to facilitate the analysis of the sample.

    SYSTEM COMPRISING AN APPARATUS AND A CARTRIDGE FOR ASSAY MEASUREMENT
    6.
    发明申请
    SYSTEM COMPRISING AN APPARATUS AND A CARTRIDGE FOR ASSAY MEASUREMENT 审中-公开

    公开(公告)号：WO2021123812A1

    公开(公告)日：2021-06-24

    申请号：PCT/GB2020/053293

    申请日：2020-12-18

    Applicant: VIDYA HOLDINGS LTD

    Inventor： VAN WORKUM, Stefan Leo ,  TUREK, Vladimir Alexander ,  DORRESTIJN, Marko ,  KLUG, David R.

    IPC: G01N21/64 ,  G01N33/52 ,  G01N21/645 ,  G01N21/648

    Abstract: An apparatus (1) for detecting the presence and/or the quantity of a target component in a biological fluid in an integrated assay cartridge (52) of predetermined configuration, the assay cartridge comprising a capture component (22) at a predetermined location in the assay cartridge, the apparatus comprising: a detector (12) for detecting the amount of light scattered, transmitted or emitted by the sample to provide an indication of the presence and/or the quantity of the target component within the sample; three location positions (30), the three positions defining a location along the optical path of the detector on which to locate the cartridge of a predetermined size; wherein location positions are configured such that the capture component of the assay cartridge is located, in use, at the focal plane of the detector. Measures to ensure quality control may also be provided.

    IMPROVEMENTS IN OR RELATING TO A SAMPLE MANAGEMENT MODULE
    8.
    发明申请
    IMPROVEMENTS IN OR RELATING TO A SAMPLE MANAGEMENT MODULE 审中-公开

    公开(公告)号：WO2020178563A1

    公开(公告)日：2020-09-10

    申请号：PCT/GB2020/050485

    申请日：2020-02-28

    Applicant: VIDYA HOLDINGS LTD

    Inventor： VAN WORKUM, Stefan Leo ,  SMITH, Callum Robertson ,  DORRESTIJN, Marko ,  KLUG, David

    IPC: B01L3/00 ,  A61B10/00

    Abstract: A sample management module for collecting a fluid sample is provided. The module comprising; a sample collection device comprising a sample collection location; a decoupling zone configured to receive sample from the collection device, an overflow reservoir in fluid communication with the decoupling zone to accommodate any sample that does not fit into the decoupling zone; wherein the overflow reservoir is configured to ensure pressure within the module can be managed. A cartridge comprising a sample management module is also provided.

    IMPROVEMENTS IN OR RELATING TO AN APPARATUS FOR IMAGING
    10.
    发明申请
    IMPROVEMENTS IN OR RELATING TO AN APPARATUS FOR IMAGING 审中-公开

    公开(公告)号：WO2022008931A1

    公开(公告)日：2022-01-13

    申请号：PCT/GB2021/051768

    申请日：2021-07-09

    Applicant: VIDYA HOLDINGS LTD

    Inventor： DORRESTIJN, Marko ,  KLUG, David R. ,  BASIT, Hajra ,  VAN WORKUM, Stefan Leo

    IPC: G01N21/51 ,  G01N21/64 ,  G01N21/65 ,  G01N33/543

    Abstract: An apparatus for imaging a plurality of assay spots is provided. The apparatus comprising a plurality of assay spots deposited onto a substrate, each assay spot comprising one or more capture components and/or one or more detection reagents; and a total internal reflection excitation microscope comprising a light source for illuminating the assay spots; a lens system is configured to launch light towards the substrate and to collect the emitted, reflected or scattered light from the assay spots, wherein the lens system comprises an objective lens; and a detector configured to detect the collected emitted, reflected or scattered light from the lens system, wherein the detector is further configured to image multiple assay spots simultaneously within a field of view.

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