公开(公告)号：WO2021260271A1

公开(公告)日：2021-12-30

申请号：PCT/FI2021/050478

申请日：2021-06-23

Applicant: TEKNOLOGIAN TUTKIMUSKESKUS VTT OY

Inventor： KOLOLUOMA, Terho ,  LIEDERT, Christina

IPC: B01L3/00 ,  F16K99/00 ,  F04D15/00 ,  B01L2300/0816 ,  B01L2300/123 ,  B01L2300/16 ,  B01L2400/043 ,  B01L2400/0481 ,  B01L2400/0638 ,  B01L3/502707 ,  B01L3/50273 ,  B01L3/502738 ,  F04D29/026 ,  F04D33/00 ,  F05D2260/404 ,  F05D2300/507 ,  F16K2099/0073 ,  F16K2099/008 ,  F16K2099/0084 ,  F16K99/0046

Abstract: The present disclosure proposes, i.a., a fluidic device (100) having a body with a first substrate (111) and a second substrate (112) which is disposed at a distance from the first substrate (111). The fluidic device (100) also has a fluidic structure (113) which is formed in the space between first substrate (111) and the second substrate (112). The fluidic device (100) features an actuating magnet (120) which is printed or coated as a film on the first substrate (111). The actuating magnet (120) produces a magnetic field for selectively deforming the first substrate (111) in reaction to another magnetic field or to the vicinity of a ferromagnetic material thus changing the volume of the fluidic structure (113).

公开(公告)号：WO2021133897A1

公开(公告)日：2021-07-01

申请号：PCT/US2020/066812

申请日：2020-12-23

Applicant: GPB SCIENTIFIC, INC.

Inventor： SKELLEY, Alison ,  GANDHI, Khushroo ,  WARD, Anthony ,  BEHMARDI, Yasna

IPC: B01L3/00 ,  B01L2200/0652 ,  B01L2300/0887 ,  B01L2300/123 ,  B01L3/502707 ,  B01L3/502753 ,  B01L3/502761

Abstract: Described herein is a microfluidic cartridge for purifying target particles or target cells of a predetermined size from contaminants in a sample, the cartridge comprising a first and a second planar support the first and second planar support each having a top surface and a bottom surface, wherein the top surface of the first and/or second planar support comprises at least one embedded channel extending from one or more inlets to one or more outlets; the at least one embedded channel comprising a plurality of obstacles, wherein the microfluidic cartridge comprises at least one void space configured to be deformed when assembling the first and second planar supports into the microfluidic cartridge.

公开(公告)号：WO2021075893A2

公开(公告)日：2021-04-22

申请号：PCT/KR2020/014135

申请日：2020-10-16

Applicant: 대한민국(농촌진흥청장)

Inventor： 백선영 ,  정학재 ,  조규호 ,  사수진

IPC: B01L9/00 ,  A01N1/02 ,  A01N1/0268 ,  B01L2200/025 ,  B01L2300/0809 ,  B01L2300/123

Abstract: 본 발명의 일 실시예에 따른 시료 융해 장치는, 판상형으로 제공되며 상부면에 시료용 스트로우가 거치되는 거치부를 포함하는 시료 융해용 트레이; 및 스트로우의 끝단을 동일선상에 위치하도록 정렬시키는 정렬기를 포함하며, 거치부는, 상부면에서 제1 방향으로 다수 개 제공되며, 일정한 간격을 가지고 나란하게 제공되는 가이드 라인; 및 가이드 라인 사이에 스트로우가 안착되도록 제공되는 안착홈을 포함한다.

公开(公告)号：WO2021016097A2

公开(公告)日：2021-01-28

申请号：PCT/US2020/042577

申请日：2020-07-17

Applicant: CYTORECOVERY, INC.

Inventor： FLESHER, Robert A.

IPC: C12Q1/6874 ,  G01N27/74 ,  C12Q1/68 ,  B01L2200/025 ,  B01L2300/0645 ,  B01L2300/0816 ,  B01L2300/0829 ,  B01L2300/0893 ,  B01L2300/123 ,  B01L3/502715 ,  B01L9/527

Abstract: Microfluidic package devices are disclosed. In one aspect of the disclosure an example microfluidic package device includes a resilient layer on top of a substrate, where the resilient layer defines at least one sample receiving well above at least one sample receiving portion and at least one outlet well above the at least one outlet portion and the resilient layer defines at least one electrode well above that at least one electrode receiving portion. Microfluidic package holders are also disclosed. Example microfluidic package holders include moveable electrodes and carrier interface cards that align with the resilient layer.

公开(公告)号：WO2021257393A1

公开(公告)日：2021-12-23

申请号：PCT/US2021/036941

申请日：2021-06-11

Applicant: SANI-TECH WEST, INC.

Inventor： BALLEW, Chris ,  SHOR, Richard

IPC: B01L3/00 ,  B01L3/02 ,  B01L9/06 ,  B01L2200/12 ,  B01L2300/042 ,  B01L2300/048 ,  B01L2300/06 ,  B01L2300/12 ,  B01L2300/123 ,  B01L2400/06 ,  B01L3/0217 ,  B01L3/502 ,  B01L3/5021 ,  B01L3/561 ,  B01L3/563

Abstract: A closed fluid receiving and sampling container that enables transfer of valuable reaction liquid to a receptacle without risking loss of sterility. The sampling container has a dip tube subassembly with a shorter inlet tube bent towards the wall of the receptacle to prevent or reduce foaming, and a longer outlet tube used to drain the waste liquid once the magnetic beads are trapped by the magnet. The dip tube subassembly is injection molded in one piece and provides a sealed cap also with a vent tube therethrough to enable filling and draining the receptacle without removing the cap, thus keeping the process aseptic. The sampling container is especially useful in the context of magnetic bead separation processes.

公开(公告)号：WO2021181081A2

公开(公告)日：2021-09-16

申请号：PCT/GB2021/050581

申请日：2021-03-09

Applicant: ORIBIOTECH LTD

Inventor： VERAITCH, Farlan ,  RAIMES, William ,  GOWLER, Vincent ,  PALMER, Jason ,  LITTEN, Neil ,  SAWFORD, Michael

IPC: C12M1/00 ,  C12M1/04 ,  C12M1/12 ,  C12M3/00 ,  B01L2200/0689 ,  B01L2300/044 ,  B01L2300/123 ,  B01L2400/0478 ,  B01L3/52 ,  C12M1/007 ,  C12M1/268 ,  C12M23/26 ,  C12M23/28 ,  C12M23/40 ,  C12M23/42 ,  C12M23/46 ,  C12M23/50 ,  C12M29/00 ,  C12M33/04 ,  C12M37/04

Abstract: There is described an assembly for handling biological material, including a planar interface having at least one port, and a component retaining element, spaced apart from the planar interface, configured to retain a component for handling biological material, in which at least one of the planar interface and the component retaining element are moveable to bring the port and the component retaining element into registration with one another. Thus, when in use, a fluid communication pathway may be provided between a component retained by the component retaining element and a container associated with the planar interface through the port.

公开(公告)号：WO2021123637A1

公开(公告)日：2021-06-24

申请号：PCT/FR2020/052499

申请日：2020-12-17

Applicant: ABC TRANSFER

Inventor： FELIX, Julien ,  SCHNEIDER, Jean-Luc ,  GIRARD, Thierry

IPC: B01L3/00 ,  B01L1/02 ,  A61B50/30 ,  A61L2/00 ,  B65B17/02 ,  B65B55/00 ,  G21F7/005 ,  A61L2/26 ,  A61B50/00 ,  B65B5/04 ,  B65B7/28 ,  B65B39/08 ,  B65B55/02 ,  A61B2050/006 ,  A61B2050/0063 ,  A61B2050/0084 ,  A61B2050/314 ,  A61L2202/18 ,  B01L2200/141 ,  B01L2200/16 ,  B01L2200/18 ,  B01L2300/043 ,  B01L2300/123 ,  B01L3/505 ,  B01L3/563 ,  B65B5/045 ,  B65B55/027

Abstract: L'invention porte sur un conteneur (1) étanche comprenant une bride (5, 6) délimitant une ouverture de passage d'axe axial dans le conteneur, une porte (7) montée mobile sur la bride (5, 6) et un premier joint d'étanchéité annulaire (13) situé entre la bride (5, 6) et la porte (7), la bride, la porte et le premier joint d'étanchéité formant un dispositif de connexion étanche apte à être raccordé à un dispositif de connexion complémentaire d'une enceinte stérile par des moyens de raccordement à baïonnette en vue de permettre un communication stérile entre le conteneur étanche et l'enceinte stérile, caractérisé en ce que le conteneur (1) comporte un capot de protection (20) du dispositif de connexion clipsé en force sur le conteneur et des moyens de pression de contact arrangés entre le capot de protection (20) et le dispositif de connexion de manière à exercer une pression de contact sur le dispositif de connexion suivant la direction axiale proportionnelle à la force de clipsage.

公开(公告)号：WO2021008867A2

公开(公告)日：2021-01-21

申请号：PCT/EP2020/068356

申请日：2020-06-30

Applicant: GLOBAL LIFE SCIENCES SOLUTIONS USA LLC ,  GLOBAL LIFE SCIENCES SOLUTIONS OPERATIONS UK LTD

Inventor： TUOHEY, Colin ,  STANKOWSKI, Ralph

IPC: B01L3/02 ,  B01L3/00 ,  C12M1/00 ,  C12M1/06 ,  C12M3/04 ,  B01L2200/0684 ,  B01L2200/147 ,  B01L2300/0609 ,  B01L2300/0627 ,  B01L2300/0832 ,  B01L2300/123 ,  B01L2300/18 ,  B01L2400/0475 ,  B01L3/505 ,  B01L3/561 ,  B01L7/00 ,  C12M23/14 ,  C12M23/26 ,  C12M23/28 ,  C12M29/00 ,  C12M37/00 ,  C12M41/12

Abstract: The present invention relates to a bioprocess bag (118) comprising a bag wall defining an enclosed volume for holding biomaterials. The bag wall comprises at least one inlet port (142) and at least one outlet port (146). The bioprocess bag (118) also comprises a tube structure (400) comprising a first opened-end proximate the bag wall and a second distal end, the tube extending into the enclosed volume, and the tube structure (400) comprising a reinforced portion (402) proximate the first opened-end.

公开(公告)号：WO2022076581A2

公开(公告)日：2022-04-14

申请号：PCT/US2021/053801

申请日：2021-10-06

Applicant: MASSACHUSETTS INSTITUTE OF TECHNOLOGY

Inventor： O'BOYLE, Duncan A. ,  GRIFFITH, Linda ,  TRUMPER, David

IPC: C12M3/06 ,  C12M1/34 ,  C12M1/00 ,  B01L3/00 ,  B01L2200/027 ,  B01L2200/0689 ,  B01L2200/12 ,  B01L2200/16 ,  B01L2300/042 ,  B01L2300/069 ,  B01L2300/0816 ,  B01L2300/0819 ,  B01L2300/0887 ,  B01L2300/123 ,  B01L2400/0481 ,  B01L2400/0487 ,  B01L2400/049 ,  B01L2400/0655 ,  B01L3/502707 ,  B01L3/502715 ,  B01L3/50273 ,  B01L3/502738 ,  B01L9/50 ,  B01L9/527 ,  B29C65/16 ,  C12M23/16 ,  C12M29/00 ,  C12M41/40 ,  F16K99/00

Abstract: Materials and methods of making have been developed for mass production of thermoplastic microfluidic chips. An elastomer diaphragm with a stress relieving feature can be used in microfluidic valves, pump diaphragms, and diaphragm micropumps. An optimized pump chamber design for complete fluid displacement and chamber geometry are provided. Microfluidic pressure regulators use a pneumatically actuated elastic membrane in a back-pressure regulator configuration. Microfluidic accumulators store pressurized fluid in a microfluidic chip. Removable caps for cell culture and a quick release top are described. Methods to incorporate hydrogels and ECM scaffolds have been developed. Electro pneumatic manifolds connect and control of multiple microfluidic devices vertically or on a rotary mechanism.

公开(公告)号：WO2022005612A1

公开(公告)日：2022-01-06

申请号：PCT/US2021/031468

申请日：2021-05-10

Applicant: MICROSOFT TECHNOLOGY LICENSING, LLC

Inventor： NGUYEN, Bichlien ,  SMITH, Jake

IPC: B01L3/00 ,  B01J19/00 ,  C12Q1/00 ,  C25B3/00 ,  B01L2200/16 ,  B01L2300/0819 ,  B01L2300/123 ,  B01L2300/165 ,  B01L2400/0427 ,  B01L2400/082 ,  B01L3/502792 ,  B01L7/525 ,  C07H1/00 ,  C07H21/04 ,  C12P19/34 ,  C12Q1/001 ,  C12Q1/6844 ,  C25D9/02

Abstract: A switchable hydrophilic surface is created by attaching electrochemically switchable hydrophilicity polymers to the surface of a microelectrode array. Ferrocene polymers are one example of electrochemically switchable hydrophilicity polymers. Activation of electrodes in the microelectrode array changes the oxidation state of metal ions which switches the polymers between hydrophobic and hydrophilic conformations. Selective activation of electrodes can create patterns of wettability on the microelectrode array that may be varied in real time. The switchable hydrophilic surface may be used to control solid-phase synthesis of polymers. Growing polymers may be selectively extended at locations on the microelectrode array that are hydrophilic. The pattern of hydrophobic and hydrophilic regions can be changed during sequential rounds of synthesis to create a variety of different polymers at different locations on the surface of the microelectrode array.