公开(公告)号：WO2015134317A1

公开(公告)日：2015-09-11

申请号：PCT/US2015/017972

申请日：2015-02-27

Applicant: WATERS TECHNOLOGIES CORPORATION

Inventor： BROUSMICHE, Darryl, W. ,  FAIRCHILD, Jacob, N. ,  HILL, Jason, F. ,  ISAAC, Giorgis ,  MORRIS, Michael, F. ,  WYNDHAM, Kevin, D.

IPC: B01D15/08 ,  B01D15/26 ,  B01J20/32

CPC classification number: B01J20/283 ,  B01D15/26 ,  B01D15/30 ,  B01D15/305 ,  B01D15/322 ,  B01D15/40 ,  B01D53/025 ,  B01J20/22 ,  B01J20/28004 ,  B01J20/28016 ,  B01J20/28042 ,  B01J20/28057 ,  B01J20/28059 ,  B01J20/28061 ,  B01J20/28064 ,  B01J20/28066 ,  B01J20/28069 ,  B01J20/28071 ,  B01J20/28073 ,  B01J20/28076 ,  B01J20/28078 ,  B01J20/28083 ,  B01J20/28085 ,  B01J20/282 ,  B01J20/284 ,  B01J20/285 ,  B01J20/288 ,  B01J20/289 ,  B01J20/3085 ,  B01J20/32 ,  B01J20/3204 ,  B01J20/3206 ,  B01J20/3208 ,  B01J20/3234 ,  B01J20/3246 ,  B01J20/3285 ,  B01J20/3293 ,  B01J2220/54 ,  B01J2220/80 ,  C07F7/1836

Abstract: The present disclosure relates to a method of separating a compound of interest, particularly unsaturated compound(s) of interest, from a mixture. The compound is separated using a column having a chromatographic stationary phase material for various different modes of chromatography containing a first substituent and a second substituent. The first substituent minimizes compound retention variation over time under chromatographic conditions. The second substituent chromatographically and selectively retains the compound by incorporating one or more aromatic, polyaromatic, heterocyclic aromatic, or polyheterocyclic aromatic hydrocarbon groups, each group being optionally substituted with an aliphatic group.

Abstract translation: 本公开涉及将目的化合物，特别是目标的不饱和化合物与混合物分离的方法。 使用具有色谱固定相材料的色谱柱分离化合物，用于各种不同的含有第一取代基和第二取代基的不同色谱方式。 在色谱条件下，第一取代基使化合物保留时间变化最小化。 第二取代基通过引入一个或多个芳族，多芳族，杂环芳族或多杂环芳族烃基来色谱和选择性地保留化合物，每个基团任选被脂族基团取代。

公开(公告)号：WO2012166916A1

公开(公告)日：2012-12-06

申请号：PCT/US2012/040205

申请日：2012-05-31

Applicant: WATERS TECHNOLOGIES CORPORATION ,  ISAAC, Giorgis ,  MCDONALD, Stephen ,  MILLAR, Alan ,  FOUNTAIN, Kenneth ,  SHOCKCOR, John

Inventor： ISAAC, Giorgis ,  MCDONALD, Stephen ,  MILLAR, Alan ,  FOUNTAIN, Kenneth ,  SHOCKCOR, John

IPC: B01D15/04

CPC classification number: B01D15/327 ,  B01D15/36 ,  B01D15/3847 ,  G01N30/482

Abstract: The present invention provides methods of separating, profiling and analyzing molecular species contained within a biological sample using a high purity chromatographic material (HPCM) comprising a chromatographic surface wherein the chromatographic surface comprises a hydrophobic surface group and one or more ionizable modifiers with the proviso that when the ionizable modifier does not contain a Zwitterion, the ionizable modifier does not contain a quaternary ammonium ion moiety.

Abstract translation: 本发明提供了使用包含色谱表面的高纯度色谱材料（HPCM）分离，分析和分析生物样品中所含的分子种类的方法，其中色谱表面包含疏水表面基团和一个或多个可离子化改性剂，条件是 当可离子化改性剂不含有两性离子时，电离改性剂不含有季铵离子部分。