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    IMMOBILIZED ENZYMATIC REACTOR
    2.
    发明申请
    IMMOBILIZED ENZYMATIC REACTOR 审中-公开
    固定化酶反应器

    公开(公告)号：WO2012112448A1

    公开(公告)日：2012-08-23

    申请号：PCT/US2012/024869

    申请日：2012-02-13

    Applicant: WATERS TECHNOLOGIES CORPORATION ,  AHN, Joomi ,  JUNG, Moon, Chul ,  WYNDHAM, Kevin, D.

    Inventor： AHN, Joomi ,  JUNG, Moon, Chul ,  WYNDHAM, Kevin, D.

    IPC: C12M1/40 ,  C12N11/00

    CPC classification number: C12Q1/37 ,  C12M21/18 ,  C12M41/40 ,  C12N11/06 ,  C12N11/14 ,  C12Q1/48

    Abstract: An immobilized enzymatic reactor can include a wall defining a chamber having an inlet and an outlet; a solid stationary phase covalently linked to an enzyme and disposed within the chamber; and a pressure modulator in fluid communication with the chamber and adapted to support continuous flow of a liquid sample comprising a polymer analyte through the inlet, over the solid stationary phase, and out of the outlet under a pressure between about 2,500 and 35,000 psi. In one example, the solid stationary phase includes inorganic/organic hybrid particles in an ultra performance liquid chromatography system, the enzyme is a protease, and the polymer analyte is a polypeptide. The immobilized enzymatic reactor can prepare an analyte for applications such as for hydrogen deuterium exchange mass spectrometry.

    Abstract translation: 固定化酶反应器可以包括限定具有入口和出口的室的壁; 与酶共价连接并置于室内的固体固定相; 以及压力调节器，其与所述腔室流体连通并且适于在约2,500至35,000psi之间的压力下支撑包含聚合物分析物的液体样品在所述固体固定相上并通过所述入口连续流过所述入口。 在一个实例中，固态固相包括超高效液相色谱系统中的无机/有机杂化颗粒，酶是蛋白酶，聚合物分析物是多肽。 固定化的酶反应器可以制备用于氢氘交换质谱法的分析物。

    ANTIMICROBIAL LAYER FOR CHROMATOGRAPHIC SYSTEMS
    3.
    发明申请
    ANTIMICROBIAL LAYER FOR CHROMATOGRAPHIC SYSTEMS 审中-公开
    用于色谱系统的抗微生物层

    公开(公告)号：WO2012006000A1

    公开(公告)日：2012-01-12

    申请号：PCT/US2011/041958

    申请日：2011-06-27

    Applicant: WATERS TECHNOLOGIES CORPORATION ,  WYNDHAM, Kevin, D. ,  BOUVIER, Edouard, S.p. ,  IRANETA, Pamela, C.

    Inventor： WYNDHAM, Kevin, D. ,  BOUVIER, Edouard, S.p. ,  IRANETA, Pamela, C.

    IPC: A01N25/08 ,  G01N30/00

    CPC classification number: A01N25/08 ,  A01N59/00 ,  A01N59/16 ,  A01N59/24 ,  B01D15/22 ,  B01L3/508 ,  B01L3/5082 ,  B01L2200/141 ,  B01L2300/16 ,  G01N30/02 ,  G01N30/06 ,  G01N2030/027 ,  A01N2300/00 ,  A01N25/10

    Abstract: A chromatographic container (1 ) incorporating an antimicrobial layer (5) or an antimicrobial device (10) with such a layer (15) for use with a standard chromatographic container (1 1 ), which layer (5, 15) inhibits, in use, microbial growth. The antimicrobial layer (5, 15) can be on an internal surface of the container (1 ) or on an exposed surface of the device (10) and may be in the form of a coating, liner or film. The layer (5, 15) may be configured for gradual release an antimicrobial agent or chemical additive, for example sodium azide. Additionally or alternatively, the antimicrobial layer (5, 15) may include silver or silver particles, for example nanoparticles of silver.

    Abstract translation: 一种含有抗微生物层（5）或抗微生物装置（10）的色谱容器（1），其具有用于标准色谱容器（11）的层（15），所述层（5,15）在使用中被抑制 ，微生物生长。 抗微生物层（5,15）可以在容器（1）的内表面上或在装置（10）的暴露表面上，并且可以是涂层，衬垫或膜的形式。 层（5,15）可以被配置为逐渐释放抗微生物剂或化学添加剂，例如叠氮化钠。 另外或替代地，抗微生物层（5,15）可以包括银或银颗粒，例如银的纳米颗粒。

    METHODS, COMPOSITIONS, DEVICES, AND KITS FOR PERFORMING PHOSPHOLIPID SEPARATION
    6.
    发明申请
    METHODS, COMPOSITIONS, DEVICES, AND KITS FOR PERFORMING PHOSPHOLIPID SEPARATION 审中-公开
    用于进行磷脂分离的方法，组合物，装置和工具

    公开(公告)号：WO2011146890A1

    公开(公告)日：2011-11-24

    申请号：PCT/US2011/037438

    申请日：2011-05-20

    Applicant: WATERS TECHNOLOGIES CORPORATION ,  IRANETA, Pamela, C. ,  WALTER, Thomas, H. ,  ZHANG, Xin ,  WALSH, Daniel, P. ,  WYNDHAM, Kevin, D. ,  FISK, Raymond, P.

    Inventor： IRANETA, Pamela, C. ,  WALTER, Thomas, H. ,  ZHANG, Xin ,  WALSH, Daniel, P. ,  WYNDHAM, Kevin, D. ,  FISK, Raymond, P.

    IPC: C07F9/02

    CPC classification number: C07F9/103 ,  B01D15/22 ,  B01D15/327 ,  B01J20/103 ,  B01J20/28004 ,  B01J20/28019 ,  B01J20/28061 ,  B01J20/28069 ,  B01J20/287 ,  B01J20/3204 ,  B01J20/3217 ,  B01J20/3246 ,  B01J20/3293 ,  B01J2220/64 ,  B01L3/5023 ,  B01L3/50255 ,  B01L2300/0681 ,  C07K1/30 ,  G01N2030/8813

    Abstract: Methods, kits and devices for separating phospholipids and proteins from small molecules in biochemical samples can feature an apparatus having a wetting barrier, at least one frit and a separation media. For example, an apparatus can include at least one wall defining a chamber having an exit and an entrance; a wetting barrier disposed between the exit and entrance, so as to define a separation media space located between the wetting barrier and the exit and a sample receiving area located between the wetting barrier and the entrance; and a separation media disposed adjacent to the wetting barrier and having a specific affinity for phospholipids. The wetting barrier is adapted to (i) retain the liquid sample and a protein precipitating agent in the sample receiving area under a first force, thereby facilitating the formation of a protein precipitate and a processed sample, and (ii) flow the processed sample through the wetting barrier and separation media under a second force, wherein the second force is greater than the first force, thereby retaining the protein precipitate in the sample receiving area, retaining phospholipids in the separation media, and eluting small molecules.

    Abstract translation: 用于从生物化学样品中分离磷脂和蛋白质与小分子的方法，试剂盒和装置可以具有具有润湿屏障的装置，至少一个玻璃料和分离介质。 例如，设备可以包括限定具有出口和入口的室的至少一个壁; 设置在出口和入口之间的润湿屏障，以便限定位于润湿屏障和出口之间的分离介质空间和位于润湿屏障和入口之间的样品接收区域; 以及与所述润湿屏障相邻并且对磷脂具有特异性亲和力的分离介质。 润湿屏障适于（i）在第一力下在样品接收区域中保留液体样品和蛋白质沉淀剂，从而有助于蛋白质沉淀物和加工样品的形成，以及（ii）将经处理的样品通过 润湿屏障和分离介质，其中第二力大于第一力，从而将蛋白质沉淀物保留在样品接收区域中，将磷脂保留在分离介质中，并洗脱小分子。

    HYBRID MATERIAL FOR CHROMATOGRAPHIC SEPARATIONS
    9.
    发明申请
    HYBRID MATERIAL FOR CHROMATOGRAPHIC SEPARATIONS 审中-公开
    用于色谱分离的混合材料

    公开(公告)号：WO2010141426A1

    公开(公告)日：2010-12-09

    申请号：PCT/US2010/036835

    申请日：2010-06-01

    Applicant: WATERS TECHNOLOGIES CORPORATION ,  WYNDHAM, Kevin, D.

    Inventor： WYNDHAM, Kevin, D.

    IPC: B01J20/02 ,  B01J20/22 ,  B01J20/281

    CPC classification number: B01J20/286

    Abstract: The present invention provides novel chromatographic materials, e.g., for chromatographic separations, processes for their preparation and separations devices containing the chromatographic materials. The preparation of the inorganic/organic hybrid materials of the invention wherein a surrounding material is condensed on a porous hybrid core material will allow for families of different hybrid packing materials to be prepared from a single core hybrid material. Differences in hydrophobicity, ion-exchange capacity, surface charge or silanol activity of the surrounding material may be used for unique chromatographic separations of small molecules, carbohydrates, antibodies, whole proteins, peptides, and/or DNA.

    Abstract translation: 本发明提供了新颖的色谱材料，例如用于色谱分离，其制备方法和含有色谱材料的分离装置。 本发明的无机/有机杂化材料的制备，其中周围材料在多孔混合芯材上冷凝，将允许从单芯混合材料制备不同混合包装材料的家族。 周围材料的疏水性，离子交换能力，表面电荷或硅烷醇活性的差异可用于小分子，碳水化合物，抗体，全蛋白，肽和/或DNA的独特色谱分离。

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