公开(公告)号：WO2010097724A1

公开(公告)日：2010-09-02

申请号：PCT/IB2010/050562

申请日：2010-02-08

Applicant: ORTHO-SPACE LTD. ,  SHOHAT, Shaul

Inventor： SHOHAT, Shaul

IPC: A61F2/42

CPC classification number: A61F2/4241 ,  A61F2/4225 ,  A61F2/4261 ,  A61F2002/0086 ,  A61F2002/30062 ,  A61F2002/30171 ,  A61F2002/302 ,  A61F2002/30224 ,  A61F2002/30242 ,  A61F2002/30252 ,  A61F2002/30261 ,  A61F2002/30273 ,  A61F2002/3028 ,  A61F2002/30576 ,  A61F2002/30581 ,  A61F2002/30909 ,  A61F2002/3093 ,  A61F2002/30932 ,  A61F2002/4258 ,  A61F2210/0004 ,  A61F2230/005 ,  A61F2230/0063 ,  A61F2230/0065 ,  A61F2230/0069 ,  A61F2230/0071 ,  A61F2230/0073 ,  A61F2230/0082 ,  A61F2230/0086 ,  A61F2310/0097

Abstract: A soft, expandable, implantable device sized for spacing between small bones comprising a first smooth surface on which a first small bone may slide. Implant (700) includes an opening (704) (passage) extending through the device for promoting fibrotic development through the opening from a direction from both thumb metacarpal (202) and trapezium (204). Passage (704) is optionally distally positioned from a one-way inflation valve (706) included inside an inflation port (702) substantially limiting possible damage to the device due to the insertion pressure of an expansion fluid. An inflation cannula and/or needle may be attached to inflation port (702) and inflation valve (706) for introducing the expansion fluid into the device. Implant (700) is inserted in a deflated mode and is positioned so that thumb metacarpal (202) abuts distal side (703) of the device when expanded and trapezium (704) abuts proximal side (701). Both distal side (703) and proximal side (701) include a smooth surface for allowing relative movement of thumb metacarpal (202) and trapezium (204) with respect to device (700).

Abstract translation: 一种柔软的，可扩张的，可植入的装置，其尺寸适于在小骨之间的间隔，其包括第一平滑表面，第一小骨可以在其上滑动。 植入物（700）包括延伸穿过该装置的开口（704），用于促进从拇指掌骨（202）和梯形（204）的方向穿过开口的纤维化发育。 通道（704）可选地远离包括在充气端口（702）内的单向充气阀（706）定位，从而基本上限制了由于膨胀流体的插入压力而对装置的可能损坏。 充气插管和/或针可以附接到充气端口（702）和充气阀（706），用于将膨胀流体引入到装置中。 植入物（700）以放气模式插入并且定位成使得当扩张和梯形（704）邻近近侧（701）时，拇指掌骨（202）邻近装置的远侧（703）。 远端侧（703）和近侧（701）均包括平滑表面，用于允许拇指掌骨（202）和梯形物（204）相对于装置（700）相对运动。

公开(公告)号：WO2007140078A2

公开(公告)日：2007-12-06

申请号：PCT/US2007/068225

申请日：2007-05-04

Applicant: DISC DYNAMICS, INC. ,  AHRENS, Michael ,  MARTZ, Erik O. ,  BURKE, Ronald ,  CARTER, Benjamin F.

Inventor： AHRENS, Michael ,  MARTZ, Erik O. ,  BURKE, Ronald ,  CARTER, Benjamin F.

IPC: A61F2/44 ,  A61F2/00 ,  A61F2/02 ,  A61F2/30 ,  A61F2/46

CPC classification number: A61F2/441 ,  A61F2002/30062 ,  A61F2002/30079 ,  A61F2002/3008 ,  A61F2002/30092 ,  A61F2002/30177 ,  A61F2002/302 ,  A61F2002/30224 ,  A61F2002/30242 ,  A61F2002/3025 ,  A61F2002/30252 ,  A61F2002/30273 ,  A61F2002/30289 ,  A61F2002/30565 ,  A61F2002/30579 ,  A61F2002/30583 ,  A61F2002/30586 ,  A61F2002/30588 ,  A61F2002/30677 ,  A61F2002/30841 ,  A61F2002/30878 ,  A61F2002/4435 ,  A61F2002/444 ,  A61F2002/4495 ,  A61F2002/4629 ,  A61F2210/0004 ,  A61F2210/0014 ,  A61F2210/0085 ,  A61F2210/009 ,  A61F2230/0056 ,  A61F2230/0065 ,  A61F2230/0069 ,  A61F2230/0071 ,  A61F2230/0073 ,  A61F2230/0086 ,  A61F2230/0091 ,  A61F2250/0098 ,  A61F2310/00011 ,  A61F2310/00179

Abstract: A mold assembly for the in situ formation of a prosthesis in an annulus located in an intervertebral disc space between adjacent vertebrae of a patient. The mold assembly includes at least a first mold having at least one interior cavity adapted to be located in the intervertebral disc space. At least a first lumen has a distal end fluidly coupled to the mold at a first location. One or more discrete reinforcing structures are located in the intervertebral disc space with the mold. One or more biomaterials are provided to be delivered to the interior cavity through the first lumen. The at least partially cured biomaterial, the reinforcing structures and the mold cooperating to form the prosthesis.

Abstract translation: 一种用于在位于患者的相邻椎骨之间的椎间盘空间中的环中原位形成假体的模具组件。 模具组件至少包括具有适于位于椎间盘空间中的至少一个内腔的第一模具。 至少第一内腔具有在第一位置处流体地联接到模具的远端。 一个或多个离散的加强结构位于与模具的椎间盘空间中。 提供一种或多种生物材料以通过第一内腔输送到内腔。 所述至少部分固化的生物材料，所述加强结构和所述模具协作以形成所述假体。

公开(公告)号：WO2007057908A2

公开(公告)日：2007-05-24

申请号：PCT/IL2006/001337

申请日：2006-11-21

Applicant: NICAST LTD. ,  ROOT, Jonathan ,  SHALEV, Alon ,  DUBSON, Alexander ,  NISSAN, Oded

Inventor： ROOT, Jonathan ,  SHALEV, Alon ,  DUBSON, Alexander ,  NISSAN, Oded

IPC: A61F2/44

CPC classification number: A61F2/441 ,  A61F2/442 ,  A61F2/4611 ,  A61F2002/30008 ,  A61F2002/30062 ,  A61F2002/30075 ,  A61F2002/30092 ,  A61F2002/30224 ,  A61F2002/30235 ,  A61F2002/30252 ,  A61F2002/30586 ,  A61F2002/30601 ,  A61F2002/30677 ,  A61F2002/30971 ,  A61F2002/4415 ,  A61F2002/444 ,  A61F2002/4495 ,  A61F2002/4627 ,  A61F2210/0004 ,  A61F2210/0014 ,  A61F2210/0061 ,  A61F2230/0069 ,  A61F2230/0073 ,  A61F2250/0017

Abstract: An implantable prosthesis device is disclosed. The prosthesis device comprises one or more compartments bounded by a substantially closed porous envelope made at least in part of non-woven polymer fibers, and a filler structure at least partially filling the compartment(s) and being made, at least in part, of non-woven swellable polymer fibers.

Abstract translation: 公开了一种可植入假体装置。 假体装置包括由至少部分无纺聚合物纤维制成的基本封闭的多孔封套限定的一个或多个隔间，以及填充物结构，至少部分地填充隔室，并且至少部分地填充隔室 无纺布可溶胀聚合物纤维。

公开(公告)号：WO2004052248A1

公开(公告)日：2004-06-24

申请号：PCT/US2003/038957

申请日：2003-12-08

Applicant: SDGI HOLDINGS, INC. ,  TRIEU, Hai, H.

Inventor： TRIEU, Hai, H.

IPC: A61F2/44

CPC classification number: A61M29/02 ,  A61B17/8858 ,  A61B2017/00539 ,  A61B2017/00557 ,  A61B2017/0256 ,  A61F2/441 ,  A61F2/4611 ,  A61F2002/2817 ,  A61F2002/30062 ,  A61F2002/3008 ,  A61F2002/30205 ,  A61F2002/30242 ,  A61F2002/30252 ,  A61F2002/30261 ,  A61F2002/30583 ,  A61F2002/30784 ,  A61F2002/444 ,  A61F2002/4445 ,  A61F2002/467 ,  A61F2210/0004 ,  A61F2210/0085 ,  A61F2230/0067 ,  A61F2230/0071 ,  A61F2230/0073 ,  A61F2230/0082 ,  A61F2250/0098 ,  A61F2310/00365 ,  A61F2310/00377 ,  A61L31/005 ,  A61L31/14 ,  A61L2430/38 ,  A61M2210/1003

Abstract: An intervertebral disc is expanded and injected by forming and dilating an opening in the disc annulus and introducing an inflatable member into the disc nucleus pulposus. The inflatable member location within the nucleus pulposus is verified and the inflatable member is gradually inflated for augmenting a space in the nucleus pulposus. The internal pressure and expansion of the inflatable member are monitored. The inflatable member is subsequently deflated and a biomaterial is injected into the augmented space.

Abstract translation: 通过形成和扩张椎间盘环中的开口并将可充气构件引入椎间盘髓核中来扩张和注射椎间盘。 验证髓核内的可膨胀构件位置，并且可膨胀构件逐渐膨胀以增加髓核中的空间。 监测充气构件的内部压力和膨胀。 随后使充气构件放气，将生物材料注入增强空间。

公开(公告)号：WO2004041131A2

公开(公告)日：2004-05-21

申请号：PCT/US2003/034641

申请日：2003-10-31

Applicant: SPINAL CONCEPTS, INC.

Inventor： KRUEGER, David, J. ,  WAGNER, Erik, J.

IPC: A61F2/46

CPC classification number: A61F2/4611 ,  A61B17/025 ,  A61B17/1604 ,  A61B17/1671 ,  A61B17/1757 ,  A61B90/94 ,  A61B2017/0256 ,  A61B2090/062 ,  A61F2/30767 ,  A61F2/4425 ,  A61F2/4684 ,  A61F2002/30062 ,  A61F2002/3008 ,  A61F2002/30112 ,  A61F2002/30252 ,  A61F2002/30365 ,  A61F2002/30378 ,  A61F2002/30383 ,  A61F2002/30448 ,  A61F2002/30451 ,  A61F2002/30528 ,  A61F2002/30616 ,  A61F2002/30617 ,  A61F2002/30639 ,  A61F2002/30649 ,  A61F2002/30662 ,  A61F2002/30695 ,  A61F2002/30713 ,  A61F2002/30714 ,  A61F2002/30823 ,  A61F2002/30828 ,  A61F2002/30841 ,  A61F2002/30848 ,  A61F2002/30878 ,  A61F2002/30879 ,  A61F2002/30884 ,  A61F2002/30891 ,  A61F2002/443 ,  A61F2002/4622 ,  A61F2002/4627 ,  A61F2002/4628 ,  A61F2002/4681 ,  A61F2210/0004 ,  A61F2220/0025 ,  A61F2220/0033 ,  A61F2220/005 ,  A61F2220/0058 ,  A61F2230/0004 ,  A61F2230/0073 ,  A61F2250/0064 ,  A61F2250/0075 ,  A61F2250/0087 ,  A61F2250/0089 ,  A61F2250/0097 ,  A61F2250/0098 ,  A61F2310/00017 ,  A61F2310/00023 ,  A61F2310/00029 ,  A61F2310/00407 ,  A61F2310/00796 ,  A61F2310/00976

Abstract: A disc implant is provided which maintains intervertebral spacing and stability within the spine. In an embodiment, a disc implant may include three or more components. Components of the implant may imitate certain physiological movements associated with a healthy spine. In certain embodiments, the components of the implant may limit physiological movements to within certain ranges, imitating normal spinal movements.

Abstract translation: 提供椎间植入物，其保持脊柱内的椎间间隔和稳定性。 在一个实施例中，盘植入物可以包括三个或更多个部件。 植入物的组件可以模仿与健康脊柱相关的某些生理运动。 在某些实施例中，植入物的组件可将生理运动限制在一定范围内，模仿正常的脊柱运动。

公开(公告)号：WO2018215471A1

公开(公告)日：2018-11-29

申请号：PCT/EP2018/063393

申请日：2018-05-22

Applicant: BUFALINI, Carlo

Inventor： BUFALINI, Carlo

IPC: A61F2/42

CPC classification number: A61F2/4241 ,  A61B17/842 ,  A61F2/42 ,  A61F2002/30252 ,  A61F2002/30754 ,  A61F2002/4258

Abstract: Trapezium-methacarpalprosthetic implant that ensures stability of the implant without limiting the freedom of movement of the hand bones. In particular, this is achieved by the shape of an interposition element.This shape of the implant allows for a freer movement of the bones with respect to one another and with respect to the prosthesis itself.

公开(公告)号：WO2010097724A9

公开(公告)日：2011-07-28

申请号：PCT/IB2010050562

申请日：2010-02-08

Applicant: ORTHO SPACE LTD ,  SHOHAT SHAUL

Inventor： SHOHAT SHAUL

IPC: A61F2/42

CPC classification number: A61F2/4241 ,  A61F2/4225 ,  A61F2/4261 ,  A61F2002/0086 ,  A61F2002/30062 ,  A61F2002/30171 ,  A61F2002/302 ,  A61F2002/30224 ,  A61F2002/30242 ,  A61F2002/30252 ,  A61F2002/30261 ,  A61F2002/30273 ,  A61F2002/3028 ,  A61F2002/30576 ,  A61F2002/30581 ,  A61F2002/30909 ,  A61F2002/3093 ,  A61F2002/30932 ,  A61F2002/4258 ,  A61F2210/0004 ,  A61F2230/005 ,  A61F2230/0063 ,  A61F2230/0065 ,  A61F2230/0069 ,  A61F2230/0071 ,  A61F2230/0073 ,  A61F2230/0082 ,  A61F2230/0086 ,  A61F2310/0097

Abstract: A soft, expandable, implantable device sized for spacing between small bones comprising a first smooth surface on which a first small bone may slide. Implant (700) includes an opening (704) (passage) extending through the device for promoting fibrotic development through the opening from a direction from both thumb metacarpal (202) and trapezium (204). Passage (704) is optionally distally positioned from a one-way inflation valve (706) included inside an inflation port (702) substantially limiting possible damage to the device due to the insertion pressure of an expansion fluid. An inflation cannula and/or needle may be attached to inflation port (702) and inflation valve (706) for introducing the expansion fluid into the device. Implant (700) is inserted in a deflated mode and is positioned so that thumb metacarpal (202) abuts distal side (703) of the device when expanded and trapezium (704) abuts proximal side (701). Both distal side (703) and proximal side (701) include a smooth surface for allowing relative movement of thumb metacarpal (202) and trapezium (204) with respect to device (700).

Abstract translation: 一种柔软的，可扩张的，可植入的装置，其尺寸适于在小骨之间的间隔，其包括第一平滑表面，第一小骨可以在其上滑动。 植入物（700）包括延伸穿过该装置的开口（704），用于促进从拇指掌骨（202）和梯形（204）的方向穿过开口的纤维化发育。 通道（704）可选地远离包括在充气端口（702）内的单向充气阀（706）定位，从而基本上限制了由于膨胀流体的插入压力而对装置的可能损坏。 充气插管和/或针可以附接到充气端口（702）和充气阀（706），用于将膨胀流体引入到装置中。 植入物（700）以放气模式插入并且定位成使得当扩张和梯形（704）邻近近侧（701）时，拇指掌骨（202）邻近装置的远侧（703）。 远端侧（703）和近侧（701）均包括平滑表面，用于允许拇指掌骨（202）和梯形物（204）相对于装置（700）相对运动。

公开(公告)号：WO2009142937A2

公开(公告)日：2009-11-26

申请号：PCT/US2009043428

申请日：2009-05-11

Applicant: WARSAW ORTHOPEDIC INC ,  ALLARD RANDALL N ,  ECKHARDT JASON JOHN ,  FRANCIS TOM J ,  ALBANS WILLIAM J ,  CARLS THOMAS A

Inventor： ALLARD RANDALL N ,  ECKHARDT JASON JOHN ,  FRANCIS TOM J ,  ALBANS WILLIAM J ,  CARLS THOMAS A

IPC: A61F2/44 ,  A61B17/70

CPC classification number: A61F2/442 ,  A61F2/3094 ,  A61F2/4425 ,  A61F2/4611 ,  A61F2002/3008 ,  A61F2002/30242 ,  A61F2002/30252 ,  A61F2002/30616 ,  A61F2002/30639 ,  A61F2002/30673 ,  A61F2002/30838 ,  A61F2002/30957 ,  A61F2230/0071 ,  A61F2230/0073 ,  A61F2250/0098

Abstract: In one aspect, an intervertebral prosthetic device for implantation within a disc space between adjacent first and second vertebral endplates includes a body including a main body with an outer surface bearing portion configured to interface with and articulate relative to one of the first and second vertebral endplates. It also comprises an orientation protrusion shaped in a manner to at least partially inhibit rotation of the body in the disc space. The body is sized in at least one direction to fit inside a boundary defined by a travel path of the first vertebra relative to the second vertebra, the travel path forming an arc about a center of rotation of the first vertebra, the travel path being spaced from the center of rotation a distance substantially equivalent to the distance from the center of rotation to the second vertebral endplate.

Abstract translation: 在一个方面，用于植入在相邻的第一和第二椎骨终板之间的椎间盘空间内的椎间假体装置包括主体，所述主体包括主体，所述主体具有外表面轴承部分，所述外表面轴承部分被配置成与所述第一和第二椎骨终板 。 它还包括以至少部分地抑制身体在椎间盘空间中旋转的方式成形的定向突起。 身体的尺寸至少在一个方向上，以装配在由第一椎骨相对于第二椎骨的行进路径限定的边界内，行进路径围绕第一椎骨的旋转中心形成弧，行进路径间隔开 从旋转中心的距离基本上等于从旋转中心到第二椎骨终板的距离。

公开(公告)号：WO2004100841A1

公开(公告)日：2004-11-25

申请号：PCT/US2004/014346

申请日：2004-05-07

Applicant: INTRINSIC THERAPEUTICS, INC. ,  LAMBRECHT, Gregory, H. ,  KAVANAUGH, Sean ,  EINHORN, Jacob

Inventor： LAMBRECHT, Gregory, H. ,  KAVANAUGH, Sean ,  EINHORN, Jacob

IPC: A61F2/44

CPC classification number: A61F2/442 ,  A61F2/28 ,  A61F2/4611 ,  A61F2002/30062 ,  A61F2002/30069 ,  A61F2002/302 ,  A61F2002/30224 ,  A61F2002/30225 ,  A61F2002/3023 ,  A61F2002/30235 ,  A61F2002/30242 ,  A61F2002/30252 ,  A61F2002/30405 ,  A61F2002/30601 ,  A61F2002/30677 ,  A61F2002/444 ,  A61F2002/4627 ,  A61F2002/4661 ,  A61F2002/4663 ,  A61F2002/4666 ,  A61F2210/0004 ,  A61F2220/0025 ,  A61F2230/0065 ,  A61F2230/0069 ,  A61F2230/0071 ,  A61F2230/0073 ,  A61F2310/00011 ,  A61F2310/00293 ,  A61F2310/00359 ,  A61F2310/00365

Abstract: A vertebral disc prosthesis (50), a method for implanting and a deployment device (80) is provided. The prosthesis (50) is for deployment within the interior of the vertebral disc for restoring the functionality of the disc (e.g., the ability of the disc to transfer nutrients or otherwise survive, the ability of the disc to carry the required loads and absorb stress or the reduction of pain). The prosthesis (50) may be made of a material having a compression strength less than about 4 mn/m 2 and may include a grouping of multiple components that can be deployed as group.

Abstract translation: 提供椎骨假体（50），植入方法和展开装置（80）。 假体（50）用于部署在椎间盘的内部以恢复椎间盘的功能（例如，椎间盘转移营养物或以其他方式存活的能力，椎间盘携带所需负荷和吸收应力的能力 或减轻疼痛）。 假体（50）可以由压缩强度小于约4mn / m 2的材料制成，并且可以包括可以作为组部署的多个部件的分组。

公开(公告)号：WO2012061024A1

公开(公告)日：2012-05-10

申请号：PCT/US2011/057011

申请日：2011-10-20

Applicant: MUSCULOSKELETAL TRANSPLANT FOUNDATION ,  SPINEOLOGY INC. ,  SEMLER, Eric, J. ,  BOYLAN, Clint ,  ROCHE, Karen

Inventor： SEMLER, Eric, J. ,  BOYLAN, Clint ,  ROCHE, Karen

IPC: A61L27/36 ,  A61F2/30

CPC classification number: A61F2/28 ,  A61B17/7095 ,  A61F2/0063 ,  A61F2/441 ,  A61F2/4601 ,  A61F2002/2817 ,  A61F2002/2839 ,  A61F2002/30057 ,  A61F2002/30062 ,  A61F2002/30224 ,  A61F2002/30242 ,  A61F2002/30252 ,  A61F2002/30253 ,  A61F2002/30261 ,  A61F2002/30273 ,  A61F2002/30588 ,  A61F2002/30677 ,  A61F2002/444 ,  A61F2002/4635 ,  A61F2002/4646 ,  A61F2002/4649 ,  A61F2310/00976 ,  A61L27/3608 ,  A61L27/3658 ,  A61L27/3683 ,  A61L27/48 ,  A61L27/54 ,  A61L2300/44

Abstract: Implants comprising a plurality of separate cortical bone units (10). which have been at least partially demineralized and are osteoinductive, are described herein. The implants can be used in methods for treating bone. Also, disclosed are methods for treating spinal conditions using these implants. The spinal conditions include but are not limited to repairing damage to or defects in the spine, such as fractures in a vertebral (30) body or degeneration of spinal discs.

Abstract translation: 植入物包括多个分离的皮质骨单元（10）。 其至少部分脱矿质并且是骨诱导的。 植入物可用于治疗骨的方法。 还公开了使用这些植入物治疗脊柱病症的方法。 脊柱病症包括但不限于修复脊柱损伤或脊柱缺损，例如椎体（30）骨折或脊椎椎间盘退变。