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    FILAMENTOUS GRAFT IMPLANTS AND METHODS OF THEIR MANUFACTURE AND USE
    1.
    发明申请
    FILAMENTOUS GRAFT IMPLANTS AND METHODS OF THEIR MANUFACTURE AND USE 审中-公开
    花丝植入物及其制造和使用方法

    公开(公告)号：WO2017096188A1

    公开(公告)日：2017-06-08

    申请号：PCT/US2016/064656

    申请日：2016-12-02

    Applicant: COOK BIOTECH INCORPORATED

    Inventor： BRONIKOWSKI, Christine, M. ,  OBERMILLER, F., Joseph ,  COLBURN, Wade, L.

    IPC: A61L27/24 ,  A61L27/36 ,  A61L31/04

    CPC classification number: A61L27/24 ,  A61L27/3683 ,  A61L31/044 ,  A61L2430/36

    Abstract: A filamentous graft has an elongate filament body including one or more intact segments of a decellularized collagenous tissue membrane. The graft can have a length of at least about 20 cm. The graft can be cut from a laminate of two or more decellularized collagenous tissue membranes. The graft can have a generally rectangular cross-section and can have substantially uniform dimensions and tensile strength along at least a substantial portion of its length. Methods for preparing and using filamentous grafts are also described.

    Abstract translation: 丝状移植物具有包括脱细胞化胶原组织膜的一个或多个完整节段的细长丝体。 移植物可以具有至少约20厘米的长度。 移植物可以从两个或更多个脱细胞胶原组织膜的层压体上切下。 移植物可以具有大致矩形的横截面并且可以沿其长度的至少大部分具有基本均匀的尺寸和拉伸强度。 还描述了制备和使用丝状移植物的方法。

    AMNIOTIC FLUID FORMULATION FOR TREATMENT OF JOINT PAIN OR DISORDER
    3.
    发明申请
    AMNIOTIC FLUID FORMULATION FOR TREATMENT OF JOINT PAIN OR DISORDER 审中-公开
    用于治疗关节疼痛或疾病的生物流体配方

    公开(公告)号：WO2017062937A1

    公开(公告)日：2017-04-13

    申请号：PCT/US2016/056231

    申请日：2016-10-10

    Applicant: MAM HOLDINGS OF WEST FLORIDA, LLC

    Inventor： HARRELL, Carl, Randall

    IPC: A61K35/50 ,  A61K9/00 ,  A61L27/00 ,  A61P19/02 ,  A61P19/04

    CPC classification number: A61K35/50 ,  A61J1/05 ,  A61K9/0014 ,  A61K9/0019 ,  A61K9/08 ,  A61K9/19 ,  A61K45/06 ,  A61L27/3604 ,  A61L27/3683 ,  A61L2400/06 ,  A61L2430/24 ,  A61L2430/34

    Abstract: A human amniotic fluid formulation has been developed for administration into a joint or associated soft tissue such as a tendon or ligament for treatment of pain, degeneration or injury. The formulation is a sterile de-cellularized human amniotic fluid (D-HAF), devoid of amniotic stemcells and elements of micronized membrane or chorion particles, which has not been heat treated or treated with ethidium bromide. The formulation is optionally diluted, or concentrated, depending on the severity of the disorder or injury. Examples demonstrate efficacy in treatment of pain, disease, disorder, degeneration or injury of a joint or associated soft.

    Abstract translation: 已经开发出人类羊水制剂用于施用于关节或相关软组织，例如用于治疗疼痛，变性或损伤的腱或韧带。 该制剂是无细胞消化的人羊水（D-HAF），没有羊水干细胞和微粉化膜或绒毛膜颗粒的元素，其尚未经溴化乙锭热处理或处理。 任选地将制剂稀释或浓缩，这取决于病症或损伤的严重程度。 实施例证明在治疗关节或相关软的疼痛，疾病，病症，变性或损伤中的功效。

    MULTI-LAYERED BIOMIMETIC MATERIAL AND METHOD OF FORMATION
    4.
    发明申请
    MULTI-LAYERED BIOMIMETIC MATERIAL AND METHOD OF FORMATION 审中-公开
    多层生物材料及其形成方法

    公开(公告)号：WO2017044573A1

    公开(公告)日：2017-03-16

    申请号：PCT/US2016/050693

    申请日：2016-09-08

    Applicant: CLEMSON UNIVERSITY

    Inventor： MCGUIRE, Rachel ,  BOREM, Ryan ,  MERCURI, Jeremy

    IPC: A61L27/24 ,  A61L27/40 ,  A61L27/50 ,  A61F2/44

    CPC classification number: A61F2/44 ,  A61L27/3604 ,  A61L27/3654 ,  A61L27/3658 ,  A61L27/3662 ,  A61L27/3683 ,  A61L27/50 ,  A61L27/52 ,  A61L2430/06 ,  A61L2430/10 ,  A61L2430/38

    Abstract: Biocompatible biomimetic materials that exhibit desirable mechanical properties while also encouraging cell ingrowth and proliferation are described. The biomaterials include a multi-layer laminate of three or more decellularized aligned collagen tissues. The individual layers are aligned with one another in an angle-ply arrangement, with the collagen of each layer aligned at an angle to the collagen of the adjacent layer. The biomaterials are useful as collagenous graft materials such as a patch for a hernia in an annulus fibrosus or grafting materials for repair of tendons, ligaments, cartilage and other musculoskeletal tissues.

    Abstract translation: 描述了显示所需机械性能同时也促进细胞向内生长和增殖的生物相容性仿生材料。 生物材料包括三层或更多种去细胞化的定向胶原组织的多层层压体。 各个层以角度布置的方式彼此对准，每层的胶原与相邻层的胶原成角度对准。 生物材料可用作胶原移植材料，例如纤维环中的疝片或用于修复腱，韧带，软骨和其他肌肉骨骼组织的嫁接材料。

    CARDIAC FIBROBLAST-DERIVED EXTRACELLULAR MATRIX AND INJECTABLE FORMULATIONS THEREOF FOR TREATMENT OF ISCHEMIC DISEASE OR INJURY
    5.
    发明申请
    CARDIAC FIBROBLAST-DERIVED EXTRACELLULAR MATRIX AND INJECTABLE FORMULATIONS THEREOF FOR TREATMENT OF ISCHEMIC DISEASE OR INJURY 审中-公开
    CARDIAC FIBROBLAST-DERIVED EXTRACELLARAR MATRIX及其用于治疗异位性疾病或损伤的注射剂

    公开(公告)号：WO2016197038A1

    公开(公告)日：2016-12-08

    申请号：PCT/US2016/035881

    申请日：2016-06-03

    Applicant: WISCONSIN ALUMNI RESEARCH FOUNDATION

    Inventor： SCHMUCK, Erik ,  RAVAL, Amish

    IPC: A61L27/36 ,  A61L27/38

    CPC classification number: A61K38/39 ,  A61K9/0019 ,  A61K9/19 ,  A61K35/34 ,  A61K45/06 ,  A61L27/3633 ,  A61L27/3683 ,  A61L27/38 ,  A61L2400/06 ,  A61L2430/20

    Abstract: Compositions and methods using an engineered cardiac fibroblast-derived 3 -dimensional extracellular matrix (ECM) are disclosed. The ECM includes the structural proteins fibronectin, collagen type I, collagen type III, and elastin, and from 60% to 90% of the structural proteins present in the engineered extracellular matrix are fibronectin. The compositions, which can be used to treat cardiac disease or ischemic disease or injury, are injectable compositions, where the ECM is diced into small fragments or lyophilized into a powder. The disclosed methods include a method of treating ischemic disease or injury by contacting a cell free patch made from the ECM with the injured tissue, without the concomitant delivery of therapeutic cells, and a method of treating ischemic limb injury by contacting a patch, either by itself or seeded with therapeutic cells, with the injured limb tissue.

    Abstract translation: 公开了使用工程化的心脏成纤维细胞衍生的3维细胞外基质（ECM）的组合物和方法。 ECM包括结构蛋白质纤连蛋白，I型胶原，III型胶原蛋白和弹性蛋白，并且工程化细胞外基质中存在的结构蛋白质的60％至90％是纤连蛋白。 可用于治疗心脏病或缺血性疾病或损伤的组合物是可注射组合物，其中将ECM切成小片段或冻干成粉末。 所公开的方法包括通过将由ECM制成的无细胞贴片与受损组织接触而不伴随治疗细胞递送来治疗缺血性疾病或损伤的方法，以及通过接触贴片来治疗缺血性肢体损伤的方法， 本身或用治疗性细胞种植，受伤的肢体组织。

    PERIODONTAL TISSUE GRAFTS
    9.
    发明申请
    PERIODONTAL TISSUE GRAFTS 审中-公开
    周围组织

    公开(公告)号：WO2016049682A1

    公开(公告)日：2016-04-07

    申请号：PCT/AU2015/000592

    申请日：2015-09-28

    Applicant: GRIFFITH UNIVERSITY

    Inventor： FARAG, Amro ,  MATTHEW, Asha ,  VAQUETTE, Cedryc ,  HUTMACHER, Dietmar ,  IVANOVSKI, Saso

    IPC: A61L27/38 ,  A61L27/44 ,  A61L27/56 ,  A61C8/00 ,  A61C13/003 ,  A61F2/28

    CPC classification number: A61L27/56 ,  A61F2/2803 ,  A61F2002/2835 ,  A61L27/3683 ,  A61L27/48 ,  A61L27/54 ,  A61L2300/406 ,  A61L2300/41 ,  A61L2430/12

    Abstract: The present invention relates to implantable decellularized biphasic periodontal tissue grafts, methods for their manufacture, and use of such grafts for the treatment of periodontal defects, periodontal diseases and periodontal tissue regeneration; said decellularized biphasic periodontal tissue graft comprises: a first polymeric scaffold comprising a plurality of first polymer fibers, and a second polymeric scaffold comprising a plurality of second polymer fibers; wherein said first and second polymeric scaffolds are interconnected; said first polymer fibers are arranged such that said first polymeric scaffold has a porous structure with an average first pore size, and said second polymer fibers are arranged such that said second polymeric scaffold has a porous structure with an average second pore size; said first polymer fibers are coated with an osteoblast-derived extracellular matrix, and said second polymer fibers are coated with a periodontal ligament cell-derived extracellular matrix.

    Abstract translation: 本发明涉及可植入脱细胞的双相牙周组织移植物，其制造方法，以及使用这种移植物治疗牙周缺损，牙周病和牙周组织再生; 所述脱细胞化双相牙周组织移植物包括：包含多个第一聚合物纤维的第一聚合物支架和包含多个第二聚合物纤维的第二聚合物支架; 其中所述第一和第二聚合物支架相互连接; 所述第一聚合物纤维布置成使得所述第一聚合物支架具有平均第一孔径的多孔结构，并且所述第二聚合物纤维布置成使得所述第二聚合物支架具有平均第二孔径的多孔结构; 所述第一聚合物纤维用成骨细胞衍生的细胞外基质涂覆，并且所述第二聚合物纤维用牙周膜细胞来源的细胞外基质包被。

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