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    DRUG DELIVERY DEVICES AND METHODS
    4.
    发明申请
    DRUG DELIVERY DEVICES AND METHODS 审中-公开
    药物递送装置和方法

    公开(公告)号：WO2015175538A1

    公开(公告)日：2015-11-19

    申请号：PCT/US2015/030379

    申请日：2015-05-12

    申请人： TARIS BIOMEDICAL LLC

    发明人： LEE, Heejin ,  DANIEL, Karen ,  LARRIVEE-ELKINS, Cheryl ,  AGARWAL, Vikas ,  HO DUC, Hong Linh

    IPC分类号： A61M31/00

    CPC分类号： A61L29/06 ,  A61K9/0034 ,  A61K9/14 ,  A61K9/20 ,  A61K31/167 ,  A61L29/14 ,  A61L29/16 ,  A61L2300/402 ,  A61M31/00 ,  A61M31/002 ,  A61M31/007 ,  A61M2205/04 ,  A61M2210/16

    摘要： Abstract of the Disclosure Drug delivery devices are provided in which much of a drug payload within the device remains within an area proximal to a wall of the device through which the drug must pass for release of the drug from the device into a patient. In one case, the device may include a drug reservoir portion which has a drug reservoir lumen bounded by a reservoir wall having an inner surface; a drug located in the drug reservoir lumen; and a core region which does not comprise the drug, wherein the drug is disposed between the inner surface of the reservoir wall and the core region. The device may be elastically deformable between a first shape suited for insertion through a lumen into a body cavity of the patient and a second shape suited to retain the device within the body cavity.

    摘要翻译： 提供了公开的药物递送装置，其中装置内的药物有效载荷中的大部分保留在靠近装置的壁的区域内，药物必须通过该区域将药物从装置释放到患者体内。 在一种情况下，装置可以包括药物储存部分，其具有由具有内表面的储存器壁限定的药物储存腔; 药物位于药物储存腔内; 以及不包含药物的核心区域，其中药物设置在储存器壁的内表面和芯区域之间。 该装置可以在适于通过内腔插入患者体腔的第一形状和适于将该装置保持在体腔内的第二形状之间弹性变形。

    COMPOSITIONS AND METHODS RELATING TO TREATMENTS OF THE ORAL CAVITY
    6.
    发明申请
    COMPOSITIONS AND METHODS RELATING TO TREATMENTS OF THE ORAL CAVITY 审中-公开
    与口腔治疗相关的组合物和方法

    公开(公告)号：WO2015123476A1

    公开(公告)日：2015-08-20

    申请号：PCT/US2015/015720

    申请日：2015-02-12

    申请人： REPLICEL LIFE SCIENCES INC.

    发明人： HOFFMANN, Rolf ,  MCELWEE, Kevin, John

    IPC分类号： A61K35/36

    CPC分类号： A61K35/36 ,  A61L27/16 ,  A61L27/225 ,  A61L27/3633 ,  A61L27/3687 ,  A61L27/38 ,  A61L27/3804 ,  A61L27/54 ,  A61L27/58 ,  A61L2300/402 ,  A61L2300/404 ,  A61L2300/41 ,  A61L2300/414 ,  A61L2300/426 ,  C12N5/0627 ,  C08L5/08

    摘要： The present invention relates to compositions and methods utilizing hair follicle derived Non-Bulbar Dermal Sheath cells for use in the treatment of dental-related conditions, including the treatment of gingivitis. Briefly stated, the present invention provides compositions and methods for treating or preventing a wide variety of conditions associated with the oral cavity, including for example, periodontal disease and a variety of diseases or injuries associated with the gingiva utilizing hair follicle derived Non-Bulbar Dermal Sheath ("NDBS") cells. Within one aspect of the invention methods are provided for isolating NBDS cells, comprising the steps of: preparing vital hair and cleaving the hair.

    摘要翻译： 本发明涉及使用来自毛囊的非球形皮肤鞘细胞用于治疗牙齿相关病症（包括治疗牙龈炎）的组合物和方法。 简而言之，本发明提供了用于治疗或预防与口腔相关的各种病症的组合物和方法，包括例如牙周疾病和使用来自非球形皮肤的毛囊的牙龈相关的各种疾病或损伤 护套（“NDBS”）细胞。 在本发明的一个方面，提供了用于分离NBDS细胞的方法，包括以下步骤：制备重要的头发和切割头发。