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    A METHOD OF SEALING A DUROTOMY
    2.
    发明申请
    A METHOD OF SEALING A DUROTOMY 审中-公开
    一种密封DUROTOMY的方法

    公开(公告)号：WO2017083050A1

    公开(公告)日：2017-05-18

    申请号：PCT/US2016/056872

    申请日：2016-10-13

    Applicant: ST. TERESA MEDICAL, INC.

    Inventor： FLOYD, Timothy

    IPC: A61F2/00 ,  A61F2/02 ,  A61F13/00 ,  A61F9/00 ,  A61K38/00 ,  A61L15/16 ,  A61L15/32

    CPC classification number: A61L15/44 ,  A61K38/363 ,  A61K38/4833 ,  A61L15/28 ,  A61L15/38 ,  A61L15/64 ,  A61L2300/418 ,  A61L2430/34 ,  C12Y304/21005

    Abstract: A method of sealing a durotomy from which cerebrospinal fluid is leaking. A durotomy sealant dressing is prepared by applying an active agent to a dextran base. The durotomy sealant dressing is applied to a durotomy. At least a portion of the durotomy sealant dressing dissolves. The durotomy is sealed with the dissolved durotomy sealant dressing to substantially prevent cerebrospinal fluid from flowing through the durotomy.

    Abstract translation: 密封脑脊液漏出的硬脊膜切开术的方法。 通过将活性剂施用于葡聚糖基质来制备硬都质密封剂敷料。 durotomy密封剂敷料应用于硬脑膜切开术。 至少一部分硬骨切开密封剂敷料溶解。 使用溶解的硬骨膜切开密封剂敷料密封硬脊膜切口，以基本上防止脑脊液流经硬脊膜切开术。

    PEPTIDE DENDRIMERS COMPRISING FIBRINOGEN-BINDING PEPTIDES
    5.
    发明申请
    PEPTIDE DENDRIMERS COMPRISING FIBRINOGEN-BINDING PEPTIDES 审中-公开
    包含纤连蛋白结合肽的肽递送剂

    公开(公告)号：WO2015104544A1

    公开(公告)日：2015-07-16

    申请号：PCT/GB2015/050024

    申请日：2015-01-08

    Applicant: HAEMOSTATIX LIMITED

    Inventor： ZBOZIEN, Renata

    IPC: A61K47/48 ,  A61L15/32

    CPC classification number: A61K47/48253 ,  A61K38/363 ,  A61K41/0019 ,  A61K47/42 ,  A61K47/641 ,  A61L26/0028 ,  A61L26/0052 ,  A61L26/0066 ,  A61L26/008 ,  A61L2300/252 ,  A61L2300/418 ,  A61L2400/04

    Abstract: Peptide dendrimers and agents are described, which can be used for polymerising fibrinogen and as haemostatic agents. The peptide dendrimers comprise a branched core, and a plurality of fibrinogen-binding peptides separately covaientiy attached to the branched core. The branched core comprises: i) from two to ten multi-functional amino acid residues, wherein each fibrinogen-binding peptide is separately covaientiy attached to a multi-functional amino acid residue of the branched core; il) a plurality of multi-functional amino acid residues, wherein one or more fibrinogen-binding peptides are separately covaientiy attached to each of at least two adjacent multi-functional amino acid residues of the branched core; Hi) a plurality of multi-functional amino acid residues, wherein two or more fibrinogen-binding peptides are separately covaientiy attached to at least one of the multi-functional amino acid residues of the branched core; iv)a plurality of multi-functional amino acid residues, wherein two or more multi-functional amino acid residues are covaientiy linked through a side chain of an adjacent multi-functional amino acid residue; or y) a single multi-functional amino acid residue, and a fibrinogen-binding peptide is separately covaientiy attached to each functional group of the multi-functional amino acid residue, The. multi-functional amino acid residues comprise tri- or tetra-functional amino acid residues, or tri- and tetra-functional amino acid residues, or the single mu!ti-funetionai amino acid residue is a tri- or tetra-functional amino acid residue.

    Abstract translation: 描述了肽树枝状大分子和试剂，其可用于聚合纤维蛋白原和作为止血剂。 肽树枝状大分子包含分支核心和分别与分支核心连接的多个纤维蛋白原结合肽。 分支核心包括：i）2至10个多官能氨基酸残基，其中每个纤维蛋白原结合肽分别与分支核心的多官能氨基酸残基连接; 1）多个多功能氨基酸残基，其中一个或多个纤维蛋白原结合肽与分支核心的至少两个相邻的多功能氨基酸残基中的每一个分别共轭连接; Hi）多个多功能氨基酸残基，其中两个或更多个纤维蛋白原结合肽分别与分支核心的至少一个多功能氨基酸残基连接; iv）多个多功能氨基酸残基，其中两个或更多个多官能氨基酸残基通过相邻的多官能氨基酸残基的侧链共同连接; 或y）单个多官能氨基酸残基，并且纤维蛋白原结合肽分别与多官能氨基酸残基的各官能团连接。 多官能氨基酸残基包含三官能或四官能氨基酸残基，或三官能和四官能氨基酸残基，或单功能氨基酸残基是三官能或四官能氨基酸残基 。

    SUBMICRON PARTICLES TO DECREASE TRANSFUSION
    9.
    发明申请
    SUBMICRON PARTICLES TO DECREASE TRANSFUSION 审中-公开
    亚微米粒子减少输血

    公开(公告)号：WO2013036902A1

    公开(公告)日：2013-03-14

    申请号：PCT/US2012054378

    申请日：2012-09-10

    Applicant: YEN RICHARD C K

    Inventor： YEN RICHARD C K

    IPC: A61K38/38 ,  A61K39/39 ,  A61P7/00 ,  B82B3/00

    CPC classification number: A61K9/0019 ,  A61K9/10 ,  A61K9/5052 ,  A61K9/5169 ,  A61K38/363

    Abstract: A submicron protein sphere and method to intravenously treat a patient requiring blood component transfusion. The submicron protein spheres have a size ranging from 1.0 micron to less than 0.1 micron and a molecular weight ranging from 780 billion Daltons to less than 0.8 billion Daltons. The protein spheres have no biologically active molecules added or bound to the protein spheres prior to administering to the patient. The protein used to construct the spheres can be human serum albumin from natural sources or recombinant DNA-derived serum albumin, or other proteins such as gelatin or synthetic polypeptides. However, the protein spheres can bind the various clotting factors including fibrinogen after the spheres have entered the blood stream, binding the necessary additional biologically active molecules supplied in vivo from the patient's own blood, and possibly in vitro.

    Abstract translation: 亚微米蛋白球和静脉内治疗需要血液成分输注的患者的方法。 亚微米蛋白球的尺寸范围从1.0微米到小于0.1微米，分子量从7,800亿道尔顿到小于8亿道尔顿。 在施用于患者之前，蛋白质球体没有添加或结合蛋白质球体的生物活性分子。 用于构建球体的蛋白质可以是来自天然来源的人血清白蛋白或重组DNA衍生的血清白蛋白，或其他蛋白质如明胶或合成多肽。 但是，球体进入血流后，蛋白质球体可以结合包括纤维蛋白原在内的各种凝血因子，从患者自身的血液中结合必要的附加的体内生物活性分子，并可能在体外结合。

    METHOD OF OBTAINING REGENERATIVE MOLECULAR MATRICES AND REGENERATIVE MOLECULAR MATRICES THUS OBTAINED
    10.
    发明申请
    METHOD OF OBTAINING REGENERATIVE MOLECULAR MATRICES AND REGENERATIVE MOLECULAR MATRICES THUS OBTAINED 审中-公开
    获得再生分子矩阵的方法和获得的再分析分子矩阵

    公开(公告)号：WO2011061561A3

    公开(公告)日：2012-08-23

    申请号：PCT/IB2009055180

    申请日：2009-11-19

    Applicant: RESTREPO ELDA

    Inventor： RESTREPO ELDA

    IPC: A61K35/14 ,  A61K38/18 ,  A61K38/36 ,  A61P19/00

    CPC classification number: A61K35/14 ,  A61K9/0051 ,  A61K9/0063 ,  A61K9/7015 ,  A61K35/32 ,  A61K38/18 ,  A61K38/30 ,  A61K38/363 ,  A61K45/06 ,  A61K2300/00

    Abstract: The present application relates to a method for obtaining regenerative molecular matrices which induce, through cell signalling, selective differentiation of the mesenchymal stem cells present in all connective tissues. Furthermore, there is claimed the matrix which is obtained by means of said method and which possesses properties of regeneration of hard and soft connective tissues, having uses for both humans and animals. The matrix disclosed is relevant for multiple applications, inter alia, for the regeneration of soft tissue, such as mucus and skin; regeneration of hard tissue, including bone and cartilage; epithelial regeneration and keratinisation; tissue adhesion, cicatrisation, conservation and autologous or cultivated cell implantation, reduction or elimination of postsurgical paresthesia, local haemostasis, release and local transfer of molecules and medicaments, bioabsorbable matrices with barrier effect (guided osseoregeneration or guided periodontal regeneration), tissue neovascularisation and revascularisation, optimisation of reimplantation of structures or tissues lost through trauma, prosthetic osseointegration, etc.

    Abstract translation: 本申请涉及一种获得再生分子基质的方法，其通过细胞信号传导诱导存在于所有结缔组织中的间充质干细胞的选择性分化。 此外，要求通过所述方法获得并且具有用于人和动物的硬和软结缔组织的再生性质的基质。 所公开的基质尤其适用于多种应用，用于软组织如粘液和皮肤的再生; 硬组织再生，包括骨和软骨; 上皮再生和角化; 组织粘连，瘢痕化，保护和自体或培养的细胞植入，减少或消除术后感觉异常，局部止血，分子和药物的释放和局部转移，具有屏障效应的生物可吸收基质（引导的骨代谢或引导的牙周再生），组织新生血管形成和血运重建 ，通过创伤，假体骨整合等丢失的结构或组织的再植入的优化

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