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    FUNCTIONALIZED SURGICAL ADHESIVES
    3.
    发明申请
    FUNCTIONALIZED SURGICAL ADHESIVES 审中-公开
    功能性手术粘合剂

    公开(公告)号：WO2010095051A2

    公开(公告)日：2010-08-26

    申请号：PCT/IB2010/000616

    申请日：2010-02-22

    Applicant: SOFRADIM PRODUCTION ,  LADET, Sébastien

    Inventor： LADET, Sébastien

    IPC: A61L24/00

    CPC classification number: A61L24/108 ,  A61L24/001 ,  A61L24/04 ,  A61L24/10

    Abstract: A bioadherent composition includes a first mixture containing a plurality of reactive members of a specific binding pair, said reactive members being bound to a ligand capable of binding a receptor on biological tissue, and a second mixture containing a plurality of complementary reactive members of the specific binding pair, said complementary reactive members being bound to a ligand capable of binding a receptor on biological tissue, said reactive members capable of forming covalent bonds with said complementary reactive members via a reaction selected from Huisgen cycloaddition reactions, Diels-Alder reactions, and/or thiol-alkene reactions. A method for bonding biological tissue involves utilizing the bioadherent composition.

    Abstract translation: 生物粘附组合物包括含有特定结合对的多个反应性成员的第一混合物，所述反应性成员结合于能够结合生物组织上的受体的配体，以及含有多个特异性结合对的互补反应性成员的第二混合物 所述互补反应性成员与能够结合生物组织上的受体的配体结合，所述反应性成员能够通过选自以下的反应形成与所述互补反应性成员共价键的反应：Huisgen环加成反应，Diels-Alder反应和/ 或硫醇 - 烯烃反应。 用于结合生物组织的方法涉及利用生物粘附组合物。

    HOMOGENEOUS, INTRINSIC RADIOPAQUE EMBOLIC PARTICLES
    5.
    发明申请
    HOMOGENEOUS, INTRINSIC RADIOPAQUE EMBOLIC PARTICLES 审中-公开
    均匀的，本质的不透射线的嵌入粒子

    公开(公告)号：WO2008054205A3

    公开(公告)日：2008-06-05

    申请号：PCT/NL2007050522

    申请日：2007-10-31

    Applicant: UNIV MAASTRICHT ,  STICHTING TECH WETENSCHAPP ,  KOOLE LEVINUS HENDRIK ,  VAN HOOY-CORSTJENS CATHARINA S

    Inventor： KOOLE LEVINUS HENDRIK ,  VAN HOOY-CORSTJENS CATHARINA S

    IPC: A61L31/18

    CPC classification number: A61L24/001 ,  A61L24/04 ,  A61L2430/36

    Abstract: The invention is directed to embolic material comprising spherical, homogeneous and substantially non-porous radiopaque polymer particles based on at least one hydrophilic monomer and at least one radiopaque monomer according to general formula (I): wherein R is H, methyl or ethyl, and R 1 is I, Br or formula (II): wherein R 2 is O, NH, 0-[CH 2 -CH 2 -O] P -C(O)-, O- [CH 2 ] m -O-C(O)-, O-[CH 2 ] p -, NH-[CH 2 -CH 2 -O] p -C(O)-, NH-[CH 2 ] m -O-C(O)- or NH-[CH 2 ] p - wherein m>l and p=l, R 3 is I or Br and n is 1, 2 or 3, the iodine and/or bromine content being at least 5 wt.% based on the dry weight of the particle, the said particles having an average particle diameter of at least 10 µm and being able to imbibe water up to a volume increase of the particle of at least 10 %.

    Abstract translation: 本发明涉及包含基于至少一种亲水性单体和至少一种根据通式（I）的不透射线单体的球形，均匀和基本上无孔的不透射线聚合物颗粒的栓塞材料：其中R是H，甲基或乙基，和 R 1是I，Br或式（II）：其中R 2是O，NH，O- [CH 2 SUB-CH 1且p = 1，R 3是I或Br，并且n是1,2或3，碘和/ 或溴含量基于颗粒干重为至少5重量％，所述颗粒具有至少10μm的平均颗粒直径，并且能够吸收水直到颗粒的体积增加至少10 ％。

    HOMOGENEOUS, INTRINSIC RADIOPAQUE EMBOLIC PARTICLES
    6.
    发明申请
    HOMOGENEOUS, INTRINSIC RADIOPAQUE EMBOLIC PARTICLES 审中-公开
    均质，内在无线电胶囊

    公开(公告)号：WO2008054205A2

    公开(公告)日：2008-05-08

    申请号：PCT/NL2007/050522

    申请日：2007-10-31

    Applicant: UNIVERSITEIT MAASTRICHT ,  STICHTING VOOR DE TECHNISCHE WETENSCHAPPEN ,  KOOLE, Levinus Hendrik ,  VAN HOOY-CORSTJENS, Catharina Sibilla Josephine

    Inventor： KOOLE, Levinus Hendrik ,  VAN HOOY-CORSTJENS, Catharina Sibilla Josephine

    IPC: A61L31/18

    CPC classification number: A61L24/001 ,  A61L24/04 ,  A61L2430/36

    Abstract: The invention is directed to embolic material comprising spherical, homogeneous and substantially non-porous radiopaque polymer particles based on at least one hydrophilic monomer and at least one radiopaque monomer according to general formula (I): wherein R is H, methyl or ethyl, and R 1 is I, Br or formula (II): wherein R 2 is O, NH, 0-[CH 2 -CH 2 -O] P -C(O)-, O- [CH 2 ] m -O-C(O)-, O-[CH 2 ] p -, NH-[CH 2 -CH 2 -O] p -C(O)-, NH-[CH 2 ] m -O-C(O)- or NH-[CH 2 ] p - wherein m>l and p≥l, R 3 is I or Br and n is 1, 2 or 3, the iodine and/or bromine content being at least 5 wt.% based on the dry weight of the particle, the said particles having an average particle diameter of at least 10 μm and being able to imbibe water up to a volume increase of the particle of at least 10 %.

    Abstract translation: 本发明涉及包含基于至少一种亲水性单体和根据通式（I）的至少一种不透射线单体的球形，均匀和基本上无孔的不透射线的聚合物颗粒的栓塞材料：其中R是H，甲基或乙基，和 R 1是I，Br或式（II）：其中R 2是O，NH，O- [CH 2 CH 2 -CH -C（O） - ， - O（CH 2）n -C（O） - ， - ，O- [CH 2 CH 2] n - ， - NH- [CH 2 CH 2 -CH 2 -O] -C（O） - ，NH- [CH 2）m -OC（O） - 或NH- [CH 其中m≥1且p = 1，R 3是I或Br，n是1,2或3，碘和/ 或溴含量基于颗粒的干重至少为5重量％，所述颗粒的平均粒径为至少10μm，并且能够将水吸收至少至少10个颗粒的体积增加 ％。

    MEDICAL ADHESIVE AND METHODS OF TISSUE ADHESION
    7.
    发明申请
    MEDICAL ADHESIVE AND METHODS OF TISSUE ADHESION 审中-公开
    医用粘合剂和组织粘合方法

    公开(公告)号：WO2007089628A3

    公开(公告)日：2008-02-21

    申请号：PCT/US2007002245

    申请日：2007-01-26

    Applicant: UNIV PITTSBURGH

    Inventor： BECKMAN ERIC J ,  ZHANG JIANYING

    IPC: A61L24/04 ,  A61L24/00

    CPC classification number: C09J175/04 ,  A61L24/0042 ,  A61L24/04 ,  A61L24/046 ,  C08G18/1808 ,  C08G18/1833 ,  C08G18/227 ,  C08G18/246 ,  C08G18/307 ,  C08G18/3206 ,  C08G18/771 ,  C08G18/8025 ,  C08L75/04

    Abstract: A method of adhering biological tissue that includes applying a bio-degradable adhesive to the tissue. The adhesive includes a moisture-curable, isocyanate-functional component prepared by reacting (a) a multi-functional isocyanate component and (b) a multi-functional active hydrogen component that includes at least 30% by weight, based upon the total weight of the multi-functional active hydrogen component, of a multi-functional active hydrogen reactant having an equivalent weight less than 100. The ratio R of active hydrogen groups to isocyanate groups can be less than 1.0.

    Abstract translation: 一种粘附生物组织的方法，包括将生物可降解粘合剂施用于组织。 粘合剂包括可湿气固化的异氰酸酯官能组分，其通过使（a）多官能异氰酸酯组分和（b）多官能活性氢组分反应制备，所述多官能活性氢组分包含至少30重量％ 具有当量重量小于100的多功能活性氢反应物的多官能活性氢组分。活性氢基团与异氰酸酯基团的比率R可以小于1.0。

    POLYMERIZABLE, INJECTABLE IN SITU IMPLANT
    9.
    发明申请
    POLYMERIZABLE, INJECTABLE IN SITU IMPLANT 审中-公开
    可聚合，可在实地植入

    公开(公告)号：WO2005089659A1

    公开(公告)日：2005-09-29

    申请号：PCT/US2005/008587

    申请日：2005-03-15

    Applicant: SCIMED LIFE SYSTEMS, INC. ,  BUCAY-COUTO, Weenna ,  LIU, Cliff

    Inventor： BUCAY-COUTO, Weenna ,  LIU, Cliff

    IPC: A61B17/12

    CPC classification number: A61L24/04

    Abstract: Methods of providing a polymeric body within a subject are described. The methods comprise: (a) injecting a fluid that comprises a crosslinkable polymer into a container (for instance, a balloon) that is positioned within the subject; (b) crosslinking the crosslinkable polymer in the container, thereby forming a crosslinked polymeric body in the container; (c) optionally washing the crosslinked polymeric body in the container; and (d) releasing the crosslinked polymeric body within the subject. Other aspects of the present invention are directed to devices for performing the above methods, and to the wide variety of polymeric bodies that can be formed using the above methods. Examples include antiadhesive bodies, aneurism fillers, embolic bodies, bulking agents, tissue scaffolding, drug delivery bodies, and so forth.

    Abstract translation: 描述了在受试者内提供聚合体的方法。 所述方法包括：（a）将包含可交联聚合物的流体注入位于受试者内的容器（例如气囊）中; （b）将容器中的可交联聚合物交联，从而在容器中形成交联的聚合体; （c）任选地洗涤容器中的交联聚合物体; 和（d）释放受试者内的交联聚合体。 本发明的其它方面涉及用于执行上述方法的装置以及可以使用上述方法形成的各种各样的聚合物体。 实例包括抗粘连体，动脉瘤填充剂，栓塞体，填充剂，组织支架，药物递送体等。

    ADHESIVE TEXTILE IMPLANT FOR PARIETAL REPAIR
    10.
    发明申请
    ADHESIVE TEXTILE IMPLANT FOR PARIETAL REPAIR 审中-公开
    粘合纺织物进行修理

    公开(公告)号：WO2005058383A2

    公开(公告)日：2005-06-30

    申请号：PCT/FR2004003218

    申请日：2004-12-14

    Applicant: COUSIN BIOTECH ,  SOLECKI GILLES

    Inventor： SOLECKI GILLES

    IPC: A61L24/04 ,  A61L31/14 ,  A61L27/34 ,  A61F2/00

    CPC classification number: A61L24/04 ,  A61L31/14

    Abstract: The invention relates to an adhesive textile implant for parietal repair, which is used in the field of reconstructive surgery. According to the invention, the implant consists of a biocompatible textile structure comprising a coating or impregnation of a water-soluble biocompatible polymer composition having adhesive properties that remain when one such implant is placed in the tissues of the organism. The invention is suitable for use as a hernia repair implant, neurological patch, etc.

    Abstract translation: 本发明涉及用于顶叶修复的粘合剂纺织植入物，其用于重建手术领域。 根据本发明，植入物由生物相容的纺织结构组成，其包括具有粘合性质的水溶性生物相容性聚合物组合物的涂层或浸渍，当将这样的植入物置于生物体的组织中时，该组合物保留。 本发明适用于疝修补植入物，神经补片等。

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