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    SHAPE MEMORY ALLOY ARTICLES WITH IMPROVED FATIGUE PERFORMANCE AND METHODS THEREFORE
    2.
    发明申请
    SHAPE MEMORY ALLOY ARTICLES WITH IMPROVED FATIGUE PERFORMANCE AND METHODS THEREFORE 审中-公开
    具有改进的疲劳性能的形状记忆合金文章及其方法

    公开(公告)号：WO2004098450A3

    公开(公告)日：2005-05-12

    申请号：PCT/US2004013157

    申请日：2004-04-29

    申请人： GORE ENTERPRISE HOLDINGS INC ,  DOOLEY BRET A ,  LASLEY CHRISTOPHER C ,  MITCHELL MICHAEL R ,  STEELE ROBERT R ,  TITTELBAUGH ERIC M

    发明人： DOOLEY BRET A ,  LASLEY CHRISTOPHER C ,  MITCHELL MICHAEL R ,  STEELE ROBERT R ,  TITTELBAUGH ERIC M

    IPC分类号： A61B17/00 ,  A61F20060101 ,  A61F2/82 ,  A61L31/02 ,  A61L31/12 ,  C22F1/00 ,  C22F1/10 ,  A61F2/06 ,  C22K1/00

    CPC分类号： A61F2/82 ,  A61B2017/00867 ,  A61C2201/007 ,  A61L31/022 ,  A61L31/121 ,  A61L31/14 ,  A61L2400/16 ,  C22F1/006

    摘要： Articles made of shape memory alloys having improved fatigue performance and to methods of treating articles formed from those materials by pre-straining the articles (or desired portions) in a controlled manner so that the resultant articles exhibit improved fatigue performance. The shape memory articles are preferably medical devices, more preferably implantable medical devices. They are most preferably devices of nitinol shape memory alloy that is superelastic at normal body temperature. The pre-straining method of the present invention includes the controlled introduction of non-recoverable tensile strains greater than about 0.20% at die surface of a desired portion of a shape memory alloy article. Controlled pre-straining operations are performed on shape-set nitinol metal to achieve non-recoverable tensile strain greater than about 0.20% at or near the surface of selected regions in the nitinol metal article. The pre-straining operations result in a significant increase in fatigue life of the selectively treated regions and an overall improvement in the fatigue performance of the device.

    摘要翻译： 由具有改善的疲劳性能的形状记忆合金制成的制品以及通过以受控方式预应变制品（或所需部分）来处理由这些材料形成的制品的方法，使得所得制品表现出改进的疲劳性能。 形状记忆物品优选是医疗装置，更优选可植入医疗装置。 它们最优选是在正常体温下超弹性的镍钛诺形状记忆合金的装置。 本发明的预应变方法包括在形状记忆合金制品的期望部分的模具表面处控制引入大于约0.20％的不可恢复的拉伸应变。 对形状金属镍金属进行控制预应变操作，以在镍钛诺金属制品的选定区域的表面处或附近实现大于约0.20％的不可恢复的拉伸应变。 预应变操作导致选择性处理区域的疲劳寿命显着增加，并且整体提高了设备​​的疲劳性能。

    MEDICAL DEVICE HAVING RADIO-OPACIFICATION AND BARRIER LAYERS
    5.
    发明申请
    MEDICAL DEVICE HAVING RADIO-OPACIFICATION AND BARRIER LAYERS 审中-公开
    具有无线电优化和障碍层的医疗设备

    公开(公告)号：WO2002076525A1

    公开(公告)日：2002-10-03

    申请号：PCT/US2002/007841

    申请日：2002-03-13

    申请人： SCIMED LIFE SYSTEMS, INC.

    发明人： CHANDRESEKARAN, Verivada, Chandru ,  KVEEN, Graig

    IPC分类号： A61L31/18

    CPC分类号： A61L31/18 ,  A61L31/121

    摘要： A medical device such as a coronary stent is provided that can be visualized in vivo ) while further aiding in the prevention of restenosis. The medical device comprises a core having a first layer disposed thereon. The first layer is made from a material that is radio-opaque so that the medical device may be visualized in-vivo. An outer layer is disposed onto and surrounds at least a portion of the first layer to provide a barrier layer between the radio-opaque inner layer and blood and/or tissue disposed within the patient's vessel. The outer surface of the outer layer may include a textured surface of micropores, grooves, cross-hatched lines to receive a therapeutic agent. Drugs and treatments which utilize anti-thombogenic agents and anti-proliferation agents may be readily deployed from the textured outer surface of the outer layer of the medical device.

    摘要翻译： 提供可以在体内可视化的医疗装置，例如冠状动脉支架，同时进一步帮助预防再狭窄。 医疗装置包括其上设置有第一层的芯。 第一层由不透射线的材料制成，使得医疗装置可以在体内可视化。 将外层设置在第一层的至少一部分上并围绕第一层的至少一部分，以在不透射线内层与设置在患者血管内的血液和/或组织之间提供阻挡层。 外层的外表面可以包括微孔的纹理表面，凹槽，交叉阴影线以接收治疗剂。 利用抗起泡剂和抗增殖剂的药物和治疗剂可以容易地从医疗装置的外层的纹理外表面展开。

    BIODEGRADABLE FRACTURE FIXATION PLATES AND USES THEREOF
    6.
    发明申请
    BIODEGRADABLE FRACTURE FIXATION PLATES AND USES THEREOF 审中-公开
    可生物降解的固定板及其用途

    公开(公告)号：WO1996000592A2

    公开(公告)日：1996-01-11

    申请号：PCT/US1995008171

    申请日：1995-06-28

    申请人： BOARD OF REGENTS, THE UNIVERSITY OF TEXAX SYSTEM

    发明人： BOARD OF REGENTS, THE UNIVERSITY OF TEXAX SYSTEM ,  AGRAWAL, C., Mauli

    IPC分类号： A61L27/00

    CPC分类号： A61L31/16 ,  A61L31/121 ,  A61L31/123 ,  A61L31/129 ,  A61L31/148 ,  A61L2300/404 ,  A61L2300/414 ,  A61L2300/602 ,  A61L2300/604 ,  A61L31/047 ,  A61B17/58 ,  C08L67/04

    摘要： The present invention provides materials for use in biodegradable structural prosthetic devices with enhanced load-bearing strength and reinforced flexibility. Prosthetic devices are also provided, which comprise a biodegradable polymer layer, reinforced by a biodegradable material, and optionally, the inclusion of pharmacologically active substances, such as growth factors and anti-microbial agents. The prosthetic devices provide for gradually decreasing structural support that lessens as the implant degrades and is compensated by new bone growth. The degradation also provides for the controlled release of the pharmacologically active agents. The prosthetic devices are exemplified by bone fixation plates.

    摘要翻译： 本发明提供了用于具有增强的承载强度和增强的柔韧性的可生物降解的结构假体装置中的材料。 还提供了包括可生物降解的聚合物层，通过可生物降解的材料增强的任选的假体装置，以及任选地包含药理学活性物质如生长因子和抗微生物剂。 假体装置提供逐渐减小的结构支撑，随着植入物降解而减少，并且通过新的骨生长来补偿。 降解还提供药理活性剂的受控释放。 假体装置以骨固定板为例。

    MEDICAL IMPLANT FORMED FROM POROUS METAL AND METHOD
    8.
    发明申请
    MEDICAL IMPLANT FORMED FROM POROUS METAL AND METHOD 审中-公开
    从多孔金属和方法形成的医用植入物

    公开(公告)号：WO2009046212A2

    公开(公告)日：2009-04-09

    申请号：PCT/US2008/078614

    申请日：2008-10-02

    申请人： ZIMMER SPINE, INC. ,  DAWSON, John M. ,  SHINBROT, Adam

    发明人： DAWSON, John M. ,  SHINBROT, Adam

    IPC分类号： A61L31/14

    CPC分类号： A61L31/146 ,  A61L31/121 ,  A61L31/14 ,  A61L31/148

    摘要： Medical implants are formed at least in part from porous metal wherein the pores of the metal are filled with a hardenable material. The hardenable material can be used to assist in the manufacture of the implant, permitting detailed machining of the implant. Further, the hardenable material can be a resorbable material that strengthens the implant during implantation but is resorbed, once implanted, to permit bone growth and infiltration. Further, in an alternate embodiment, the hardenable material can be a thermoplastic material that can be heated by ultrasonic energy to create an adhesive bond between a fastener and bone structure.

    摘要翻译： 医疗植入体至少部分地由多孔金属形成，其中金属的孔填充有可硬化的材料。 可硬化材料可用于辅助植入物的制造，允许植入物的详细加工。 此外，可硬化材料可以是可植入材料，其可以在植入期间加强植入物，但是一旦植入就被再吸收，以允许骨生长和渗透。 此外，在另一个实施例中，可硬化材料可以是能够被超声能量加热以在紧固件和骨结构之间形成粘结剂的热塑性材料。