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    INHALER
    2.
    发明申请
    INHALER 审中-公开

    公开(公告)号：WO2015110832A1

    公开(公告)日：2015-07-30

    申请号：PCT/GB2015/050163

    申请日：2015-01-23

    申请人： TEAM HOLDINGS (UK) LIMITED

    发明人： HARRIS, David Stuart ,  HARVEY, Oliver

    IPC分类号： A61M15/00 ,  A61M11/00

    CPC分类号： A61M15/0086 ,  A61M11/002 ,  A61M15/0003 ,  A61M15/0005 ,  A61M15/003 ,  A61M15/0035 ,  A61M15/0038 ,  A61M2202/064 ,  A61M2206/14 ,  A61M2206/16

    摘要： An inhaler (2) is for use with a pharmaceutical capsule (36) containing an active pharmaceutical ingredient (API) and a carrier powder. The inhaler (2) comprises a capsule opener, a capsule chamber (12) for retaining an opened capsule (36), and a deagglomeration chamber (16) for detaching at least a portion of the API from the carrier powder. When a user inhales through an inhaler outlet downstream of the deagglomeration chamber, air enters the capsule chamber (12) through an air inlet (24), flows from the capsule chamber (12) into the deagglomeration chamber (16), and out of the outlet. The user's inhalation generates air pressures P i at the outlet, P int between the capsule chamber (12) and the deagglomeration chamber (16) and P o at the outlet. The inhaler (2) is designed such that (P int -P o )/(P i - P o )>0.33.

    摘要翻译： 吸入器（2）用于含有活性药物成分（API）和载体粉末的药物胶囊（36）。 吸入器（2）包括胶囊开启器，用于保持打开的胶囊（36）的胶囊室（12）和用于从载体粉末中分离至少一部分API的解聚集室（16）。 当用户通过吸入器出口在分解室下游吸入时，空气通过空气入口（24）进入胶囊室（12），从胶囊室（12）流入解聚室（16），并从 出口。 用户的吸入产生空气压力，将出口，胶囊室（12）和解聚集室（16）之间的Pint和P out插入出口。 吸入器（2）的设计使得（Pint-Po）/（Pi- Po）> 0.33。

    A BLISTER PIERCING ELEMENT FOR A DRY POWDER INHALER
    3.
    发明申请
    A BLISTER PIERCING ELEMENT FOR A DRY POWDER INHALER 审中-公开
    一种用于干燥粉末吸入器的泡沫刺激元件

    公开(公告)号：WO2014114916A1

    公开(公告)日：2014-07-31

    申请号：PCT/GB2014/050132

    申请日：2014-01-17

    申请人： VECTURA DELIVERY DEVICES LIMITED

    发明人： WILSON, Peter ,  MELINIOTIS, Andreas

    IPC分类号： A61M15/00

    CPC分类号： A61M15/0035 ,  A61M15/0021 ,  A61M15/0038 ,  A61M15/004 ,  A61M15/0041 ,  A61M15/0045 ,  A61M15/0051 ,  A61M15/0091 ,  A61M2202/064 ,  A61M2205/8225 ,  A61M2205/8275 ,  A61M2210/0618 ,  A61M2210/0625

    摘要： A blister piercing element for puncturing the lid of a blister containing a dose of medicament for inhalation by a user is disclosed. It comprises a body having a surface and an opening in the surface for the passage of air, or for the passage of medicament entrained in air, through the body. The body includes a pair of spaced cutting teeth upstanding from the surface in spaced side-by-side relation, each cutting tooth projecting in cantilevered form over said opening and each having a distal cutting edge at a free end remote from said surface. The distal cutting edge of each tooth is configured to initiate a slit in a blister lid when pressure is applied to a blister lid by the teeth and the teeth are spaced from each other so that separate slits cut by the distal cutting edge of each tooth propagate in a direction toward each other between the teeth as the teeth continue to penetrate a blister lid. The pair of spaced cutting teeth form a single slit in a blister lid that defines a single flap which is folded into the blister by the teeth.

    摘要翻译： 公开了一种用于刺穿包含用于用户吸入的剂量的泡罩的泡罩的泡罩刺穿元件。 它包括一个主体，该主体具有表面和用于空气通过的开口，或者使夹带在空气中的药物通过本体。 主体包括一对间隔开的切割齿，其从表面以间隔开的并排关系直立，每个切割齿以悬臂形式突出在所述开口上，并且每个具有远离所述表面的自由端的远端切割刃。 每个齿的远端切割边缘被配置为当通过齿将压力施加到泡罩盖上时启动在泡罩中的狭缝，并且齿彼此间隔开，使得由每个齿的远端切割刃切割的单独狭缝传播 当牙齿继续穿透泡罩盖时，在朝向彼此的方向之间。 一对隔开的切割齿在泡罩中形成单个狭缝，该狭缝限定单个翼片，其通过牙齿折叠到泡罩中。

    SEMI-AUTOMATIC EMERGENCY MEDICATION DOSE NEBULIZER
    5.
    发明申请
    SEMI-AUTOMATIC EMERGENCY MEDICATION DOSE NEBULIZER 审中-公开
    半自动应急剂量NEBULIZER

    公开(公告)号：WO2010002421A1

    公开(公告)日：2010-01-07

    申请号：PCT/US2009/001634

    申请日：2009-03-13

    申请人： ABRAMS, Robert

    发明人： ABRAMS, Robert

    IPC分类号： A61M11/02 ,  A61M15/00

    CPC分类号： A61M11/02 ,  A61M15/0028 ,  A61M15/0031 ,  A61M15/0038 ,  A61M15/0041 ,  A61M16/0063 ,  A61M2205/583 ,  A61M2205/587 ,  A61M2209/045

    摘要： A conventional respiratory nebulizer has an emergency medication dose storage system delivering the stored medication dose directly to the nebulizing chamber with a single impulse of manual force to a simple mechanical delivery system, thereby making the nebulizer useable in two steps: (a) opening the medication capsule with a simple opening action; and (b) inhaling the nebulized medication. The nebulizer can be operated without disassembling the nebulizer housing so as to expose the nebulizing chamber and without manually opening the liquid medication container and, without spillage and without manual pouring of the liquid medication directly into the nebulizing chamber, and without reassembling the nebulizer housing before positioning the inhaler mouthpiece in the mouth so as to inhale the nebulized medication. The delivery system includes a serrated slicing blade to sever the capsule.

    摘要翻译： 常规呼吸雾化器具有紧急药物剂量存储系统，其将存储的药物剂量直接输送到雾化室，其具有单个手动力的脉冲至简单的机械输送系统，从而使雾化器可以分两步使用：（a）打开药物 胶囊具有简单的开启动作; 和（b）吸入雾化药物。 雾化器可以在不拆卸雾化器壳体的情况下操作，以便暴露雾化室，而不用手动打开液体药物容器，并且不会溢出并且没有将液体药物直接注入雾化室中，并且没有在雾化器壳体之前重新组装 将吸入器吸嘴定位在口中，以吸入雾化药物。 输送系统包括切割胶囊的锯齿切片刀片。

    INHALATION DEVICE
    7.
    发明申请
    INHALATION DEVICE 审中-公开
    吸入装置

    公开(公告)号：WO2007018568A1

    公开(公告)日：2007-02-15

    申请号：PCT/US2005/038147

    申请日：2005-10-21

    申请人： MANTA DEVICES, LLC ,  JONES, Andrew ,  MILLER, Richard

    发明人： JONES, Andrew ,  MILLER, Richard

    IPC分类号： A61M15/00

    CPC分类号： A61M15/0045 ,  A61M11/003 ,  A61M11/02 ,  A61M15/0003 ,  A61M15/0005 ,  A61M15/001 ,  A61M15/0028 ,  A61M15/0038 ,  A61M15/0043 ,  A61M15/0048 ,  A61M15/0061 ,  A61M15/0065 ,  A61M15/0075 ,  A61M15/0085 ,  A61M2202/064 ,  A61M2205/07 ,  A61M2206/16

    摘要： The present invention provides for the integration of drug dispersion methods into a packaging device. The drug dispersion methods used include shear (e.g., air across a drug, with or without a gas assist), capillary flow or a venturi effect, mechanical means such as spinning, vibration, or impaction, and turbulence (e.g., using mesh screens, or restrictions in the air path). These methods of drug dispersion allow for all of the drug in the packaging device to be released, allowing control of the dosage size. These methods also provide for drug metering, fluidization, entrainment, deaggragation and deagglomeration. The present invention also provides for the integration of a drug sealing system into the packaging device.

    摘要翻译： 本发明提供将药物分散方法整合到包装装置中。 使用的药物分散方法包括剪切（例如，具有或不具有气体辅助的药物的空气），毛细管流动或文丘里效应，诸如旋转，振动或冲击的机械手段和湍流（例如，使用筛网， 或限制在空中路径）。 这些药物分散方法允许释放包装装置中的所有药物，从而控制剂量大小。 这些方法还提供了药物计量，流化，夹带，解聚和解聚。 本发明还提供了将药物密封系统整合到包装装置中。

    A SIMPLE CAPSULE-BASED INHALER
    9.
    发明申请
    A SIMPLE CAPSULE-BASED INHALER 审中-公开
    简单的基于胶囊的吸入器

    公开(公告)号：WO2011135327A1

    公开(公告)日：2011-11-03

    申请号：PCT/GB2011/050760

    申请日：2011-04-18

    申请人： HOVIONE INTERNATIONAL LTD. ,  VILLAX, Peter ,  MENDES, Pedro ,  McDERMENT, Iain

    发明人： VILLAX, Peter ,  MENDES, Pedro ,  McDERMENT, Iain

    IPC分类号： A61M15/00

    CPC分类号： A61M15/0028 ,  A61M11/001 ,  A61M15/0038 ,  A61M15/004 ,  A61M15/0063 ,  A61M2202/064 ,  A61M2205/581 ,  A61M2205/582

    摘要： A dry powder inhaler for pulmonary or nasal use, employing capsules (323) containing a dose of powder for inhalation, comprising two operating components and an optional cover. Air is drawn by the patient via a mouthpiece or nosepiece (303) which is in communication with the capsule (323) and travels via air paths through the device and through the capsule (323) thereby dispersing and entraining the dose of powder. The capsule (323) is cut by cutting means (350, 351) located on one of the components (300), in a manner which eliminates or minimizes capsule debris and minimizes powder leakage during use. The inhaler body (300) and capsule cutting blades (350, 351) comprise a single operating component and they may be manufactured in a single unitary step. The invention affords a very economical and simple device for the delivery of pulmonary medicines.

    摘要翻译： 一种用于肺或鼻用的干粉吸入器，使用含有一定剂量的用于吸入的粉末的胶囊（323），包括两个操作部件和可选的盖。 空气由患者通过与胶囊（323）连通并经由空气通道穿过装置并通过胶囊（323）的接口管或鼻梁（303）吸引，从而分散和夹带粉剂的剂量。 胶囊（323）由位于其中一个部件（300）上的切割装置（350,351）切割，以消除或最小化胶囊碎屑并使使用期间的粉末泄漏最小化的方式。 吸入器主体（300）和胶囊切割刀片（350,351）包括单个操作部件，并且它们可以以单个单一步骤制造。 本发明提供了用于递送肺部药物的非常经济且简单的装置。

    DRY POWDER INHALER WITH FLUTTER DISPERSION MEMBER
    10.
    发明申请
    DRY POWDER INHALER WITH FLUTTER DISPERSION MEMBER 审中-公开
    带颤动分散部件的干粉吸入器

    公开(公告)号：WO2011060334A2

    公开(公告)日：2011-05-19

    申请号：PCT/US2010/056628

    申请日：2010-11-12

    申请人： STC.UNM ,  SMYTH, Hugh, D.C. ,  SELVAM, Parthiban ,  TRUMAN, Charles, Randall

    发明人： SMYTH, Hugh, D.C. ,  SELVAM, Parthiban ,  TRUMAN, Charles, Randall

    CPC分类号： A61M15/0028 ,  A61M11/003 ,  A61M15/0031 ,  A61M15/0038 ,  A61M15/0086 ,  A61M2202/064 ,  A61M2205/0233 ,  A61M2206/16

    摘要： A dry powder inhaler including a housing defining a chamber for receiving a dose of powdered medicament, an inhalation port in fluid communication with the chamber, at least one airflow inlet providing fluid communication between the chamber and an exterior of the housing, and a flutter element in the chamber and associated with a dose of powdered medicament. The flutter element has a tensioned distal end proximate the at least one airflow inlet and a free proximal end opposite to the distal end and downstream of the inlet. The flutter element is configured to vibrate in response to airflow through the chamber and aerosolize the dose of powdered medicament.

    摘要翻译： 一种干粉吸入器，包括限定用于接收一剂粉末状药剂的腔室的壳体，与腔室流体连通的吸入端口，至少一个气流入口，所述至少一个气流入口提供腔室与外部之间的流体连通 壳体中的颤动元件以及腔室中的颤动元件并且与一定剂量的粉状药剂相关联。 颤动元件具有靠近至少一个气流入口的张紧远端和与远端相对且在入口下游的自由近端。 颤振元件构造成响应于通过腔室的气流而振动并且雾化剂量的粉状药物。