公开(公告)号：WO2006115910A2

公开(公告)日：2006-11-02

申请号：PCT/US2006/014586

申请日：2006-04-19

Applicant: HARSCO CORPORATION ,  DITZIG, Joseph ,  CHIRKOT, Thomas ,  LY, Kiet C.

Inventor： DITZIG, Joseph ,  CHIRKOT, Thomas ,  LY, Kiet C.

IPC: B01F9/00

CPC classification number: B01F9/0009 ,  B01F9/0036 ,  B01F9/005 ,  B01F9/08 ,  B01F15/0235 ,  B01F2009/0089

Abstract: The present invention provides a continuous blender having a drive unit assembly with a shell assembly mounting assembly and a shell assembly structured to be removably coupled to the shell assembly mounting assembly by one or more clamps. The drive unit assembly may be coupled to shell assemblies having different lengths and diameters. Thus, by changing the shell assembly coupled to the drive unit assembly, the output of the continuous blender may be dramatically changed.

Abstract translation: 本发明提供一种具有驱动单元组件的连续式搅拌器，该驱动单元组件具有外壳组件安装组件和壳体组件，壳体组件构造成通过一个或多个夹具可拆卸地联接到壳体组件安装组件。 驱动单元组件可以联接到具有不同长度和直径的壳组件。 因此，通过改变耦合到驱动单元组件的壳体组件，连续搅拌器的输出可能会发生显着变化。

公开(公告)号：WO2010042151A2

公开(公告)日：2010-04-15

申请号：PCT/US2009/005440

申请日：2009-10-03

Applicant: KALIDINDI, Sanyasi, R.

Inventor： KALIDINDI, Sanyasi, R.

IPC: A61J3/02 ,  B01F7/04

CPC classification number: B01F9/04 ,  B01F3/18 ,  B01F9/005 ,  B01F9/08 ,  B07B1/24

Abstract: A tumbler (14) is mounted for rotation around a trunnion (30) with a screen (20) fixedly mounted to a portion of the trunnion (30) residing within the tumbler (14). A multiple blade paddle (24) is mounted to a shaft (26) that is rotatably supported through the trunnion (30). The paddle (24) blades are formed with angular edges. As the tumbler (14) rotates and the paddle (24) rotates, powder (P) is repeatedly dropped onto the screen (20) to be sifted with the aid of the paddle (24). Rotating the tumbler (14) further drops unsifted portions of the powder (P) out of the screen (20) to mix with additional powder (P) in the tumbler (14) body. Thus, sifting and blending of powders is accomplished in one single operation.

Abstract translation:

转鼓（14）被安装用于围绕耳轴（30）的屏幕（20）的旋转固定地安装到驻留在转鼓（14）内的耳轴（30）的至少一部分。 多叶片桨叶（24）安装到通过耳轴（30）可旋转地支撑的轴（26）。 桨叶（24）形成有棱角边缘。 当转筒（14）旋转并且桨叶（24）旋转时，粉末（P）通过桨叶（24）重复地落在筛网（20）上以被筛选。 旋转转筒（14）进一步使粉末（P）的未固定部分脱离筛网（20）以与转筒（14）主体中的另外的粉末（P）混合。 因此，筛选和混合粉末是在一次操作中完成的。

公开(公告)号：WO01060507A1

公开(公告)日：2001-08-23

申请号：PCT/GB2001/000559

申请日：2001-02-12

IPC: G08C17/02 ,  B01F7/00 ,  B01F9/00 ,  B01F9/02 ,  B01F9/04 ,  B01F11/00 ,  B01F13/00 ,  B01F15/00 ,  G01N21/25 ,  G01N21/35

CPC classification number: B01F9/0018 ,  B01F7/00908 ,  B01F9/0005 ,  B01F9/0043 ,  B01F9/005 ,  B01F9/04 ,  B01F11/0017 ,  B01F13/0035 ,  B01F15/00207 ,  B01F2215/0032 ,  G01N21/3563 ,  G01N21/3577 ,  G01N21/359

Abstract: Mixing of components, e.g. pharmaceutical actives and excipients, is carried out while monitoring the spectroscopic profile of the mixture during the mixing process so that the spectroscopic profile may be used to determine the point at which mixing is terminated. In one embodiment of the invention, the spectroscopic data is collected by means of a monitoring unit mounted on the mixing vessel. the mixing vessel being mounted and driven so as to rotate or oscillate mounted and thereby effect mixing of its contents and the monitoring unit being mounted for rotation or oscillation with the vessel. When the spectroscopic data indicates that mixing has progressed to a desired state, e.g. the production of a homogeneous blend, the monitoring unit transmits a signal to the drive source to terminate rotation or oscillation of the vessel.

Abstract translation: 组分的混合，例如 药物活性物质和赋形剂，同时在混合过程中监测混合物的光谱曲线，以便可以使用光谱分布来确定混合终止的点。 在本发明的一个实施例中，通过安装在混合容器上的监测单元收集光谱数据。 混合容器被安装和驱动以便安装并旋转或摆动，从而使其内容物与监测单元的混合被安装成与容器一起旋转或振荡。 当光谱数据表明混合进行到所需状态时，例如， 制造均匀混合物时，监测单元向驱动源发送信号以终止容器的旋转或振荡。

公开(公告)号：WO2014031425A1

公开(公告)日：2014-02-27

申请号：PCT/US2013/055059

申请日：2013-08-15

Applicant: BANUS, Christopher, T.

Inventor： BANUS, Christopher, T.

IPC: B01F11/02 ,  B01F7/16

CPC classification number: B01F11/0225 ,  B01F3/0819 ,  B01F3/1242 ,  B01F5/065 ,  B01F7/0015 ,  B01F7/00208 ,  B01F7/0045 ,  B01F7/047 ,  B01F7/08 ,  B01F7/161 ,  B01F7/165 ,  B01F7/1665 ,  B01F7/18 ,  B01F7/30 ,  B01F7/32 ,  B01F9/005 ,  B01F9/02 ,  B01F11/02 ,  B01F11/0241 ,  B01F11/0258 ,  B01F11/0266 ,  B01F15/00746

Abstract: A batch or continuous mixer for mixing powders, immiscible liquids, or a powder with a liquid includes one or more vibrational energy applicators which propagate vibrational energy into the mixture, causing powders to flow like liquids and breaking up liquid droplets and powder clumps. In embodiments, the vibration frequency and amplitude are selected according to properties of the mixture components. Vibrations can be propagated through container walls, impellers, or other structures within the mixing container. Vibrated structures can be flexibly supported for enhanced propagation of the vibrations. Vibrational energy can be uniform throughout the container, or focused in a desired region. Ultrasonic energy can be simultaneously applied with acoustic energy.

Abstract translation: 用于混合粉末，不混溶液体或具有液体的粉末的分批或连续混合器包括一个或多个振动能量施加器，其将振动能量传播到混合物中，导致粉末像液体一样流动并分解液滴和粉末团块。 在实施例中，根据混合物组分的特性来选择振动频率和振幅。 振动可以通过容器壁，叶轮或混合容器内的其他结构传播。 可以灵活地支撑振动结构以增强振动的传播。 振动能量可以在整个容器中是均匀的，或者聚焦在期望的区域中。 超声波能量可同时施加声能。

公开(公告)号：WO2006115910A3

公开(公告)日：2007-11-01

申请号：PCT/US2006014586

申请日：2006-04-19

Applicant: HARSCO CORP ,  DITZIG JOSEPH ,  CHIRKOT THOMAS ,  LY KIET C

Inventor： DITZIG JOSEPH ,  CHIRKOT THOMAS ,  LY KIET C

IPC: B01F9/08

CPC classification number: B01F9/0009 ,  B01F9/0036 ,  B01F9/005 ,  B01F9/08 ,  B01F15/0235 ,  B01F2009/0089

Abstract: The present invention provides a continuous blender having a drive unit assembly with a shell assembly mounting assembly and a shell assembly structured to be removably coupled to the shell assembly mounting assembly by one or more clamps. The drive unit assembly may be coupled to shell assemblies having different lengths and diameters. Thus, by changing the shell assembly coupled to the drive unit assembly, the output of the continuous blender may be dramatically changed.

Abstract translation: 本发明提供一种具有驱动单元组件的连续式搅拌器，该驱动单元组件具有外壳组件安装组件和壳体组件，壳体组件构造成通过一个或多个夹具可拆卸地联接到壳体组件安装组件。 驱动单元组件可以联接到具有不同长度和直径的壳组件。 因此，通过改变耦合到驱动单元组件的壳体组件，连续搅拌器的输出可能会发生显着变化。

公开(公告)号：WO2010042151A3

公开(公告)日：2010-09-02

申请号：PCT/US2009005440

申请日：2009-10-03

Applicant: KALIDINDI SANYASI R

Inventor： KALIDINDI SANYASI R

IPC: A61J3/02 ,  B01F7/04

CPC classification number: B01F9/04 ,  B01F3/18 ,  B01F9/005 ,  B01F9/08 ,  B07B1/24

Abstract: A tumbler (14) is mounted for rotation around a trunnion (30) with a screen (20) fixedly mounted to a portion of the trunnion (30) residing within the tumbler (14). A multiple blade paddle (24) is mounted to a shaft (26) that is rotatably supported through the trunnion (30). The paddle (24) blades are formed with angular edges. As the tumbler (14) rotates and the paddle (24) rotates, powder (P) is repeatedly dropped onto the screen (20) to be sifted with the aid of the paddle (24). Rotating the tumbler (14) further drops unsifted portions of the powder (P) out of the screen (20) to mix with additional powder (P) in the tumbler (14) body. Thus, sifting and blending of powders is accomplished in one single operation.

Abstract translation: 转筒（14）被安装成围绕耳轴（30）旋转，其中屏幕（20）固定地安装在位于转筒（14）内的耳轴（30）的一部分上。 多叶片桨叶（24）安装到可旋转地支撑穿过耳轴（30）的轴（26）上。 桨叶（24）叶片形成有角度边缘。 当转鼓（14）旋转并且桨叶（24）旋转时，粉末（P）被重复地落在筛网（20）上，以借助桨叶（24）进行筛分。 旋转转筒（14）还将粉末（P）的未被磨碎的部分从筛网（20）中脱出，以便与转筒（14）主体中的附加粉末（P）混合。 因此，粉末的筛选和混合是在一次操作中完成的。

公开(公告)号：WO2003094679A2

公开(公告)日：2003-11-20

申请号：PCT/US2003/013373

申请日：2003-04-30

Applicant: EURO-CELTIQUE, S.A. ,  GEHRLEIN, Lane ,  CIURCZAK, Emil ,  RITCHIE, Gary

Inventor： GEHRLEIN, Lane ,  CIURCZAK, Emil ,  RITCHIE, Gary

IPC: A47J

CPC classification number: B01F9/04 ,  B01F3/02 ,  B01F9/005 ,  B01F15/00207

Abstract: A blending apparatus comprises a. blender including a container having a wall, the wall including a window. The container rotates about an axis of rotation. A wireless spectrometer is mounted to the container and operates through the window, in a direction that does not intersect the axis of rotation, for obtaining a set of spectroscopic data regarding the product during an operation of the blender. In addition, a method for assaying a blended product in a blender includes mounting a wireless spectrometer to the container, rotating the container about its axis of rotation so as to blend the product; operating the wireless spectrometer through a window in the container, in a direction that does not intersect the axis of rotation, to obtain spectroscopic data regarding the product during the blending, and determining a homogeneity of the product from the spectroscopic data.

Abstract translation: 混合装置包括a。 搅拌器包括具有壁的容器，所述壁包括窗口。 容器围绕旋转轴线旋转。 将无线光谱仪安装到容器上，并且在与旋转轴线不相交的方向上通过窗口操作，以在搅拌器的操作期间获得关于产品的一组光谱数据。 此外，用于在混合器中测定混合产品的方法包括将无线光谱仪安装到容器上，使容器围绕其旋转轴线旋转以便混合产品; 通过容器中的窗口沿不与旋转轴线相交的方向操作无线光谱仪，以获得关于混合期间产品的光谱数据，以及根据光谱数据确定产品的均匀性。

公开(公告)号：WO1997016240A1

公开(公告)日：1997-05-09

申请号：PCT/US1996017178

申请日：1996-10-25

Applicant: MERCK & CO., INC. ,  RUTGERS, THE STATE UNIVERSITY OF NEW JERSEY ,  ROBINSON, Priscilla, A. ,  MUZZIO, Fernando, J. ,  BRONE, Dean ,  CONNOR, Kevin ,  WIGHTMAN, Carolyn

Inventor： MERCK & CO., INC. ,  RUTGERS, THE STATE UNIVERSITY OF NEW JERSEY

IPC: B01F09/02

CPC classification number: B01F9/005 ,  B01F9/0005 ,  B01F9/0018 ,  B01F9/08 ,  B01F11/0062 ,  B01F13/0035 ,  B01F13/004 ,  B01F15/00123 ,  B01F15/0201 ,  B01F2009/0065 ,  B01F2009/0072 ,  B01F2009/0089

Abstract: A study was done to compare the performance of a conventional V-blender to a V-blender that incorporates perturbations of the particle flow by rocking the mixing vessel during its normal rotation. Mixing was investigated using glass beads with sizes from 66 mu to 600 mu in vessels of approximately one liter volume. Mixture uniformity was assessed qualitatively, using two different methods. One method involved a transparent mixing vessel where it was possible to see particle flow patterns and assess the state of the mixture at its surface during the entire experiment. The second method involved disposable aluminum mixing vessels, where the mixture was solidified by infiltrating the mixture with a binder. By slicing the solidified structure, it was possible to assess the entire state of the mixture including its interior structure after the completion of each experiment. Mixture uniformity was also assessed quantitatively using image analysis of the slices. For both particles sizes, the extent of mixing was greatly enhanced using the rocking V-blender compared to the conventional V-blender.

Abstract translation: 进行了一项研究，以比较常规V型搅拌机与V型搅拌机的性能，V型搅拌机在正常旋转期间摇摆混合容器，从而混合了颗粒流动的扰动。 使用大约1升体积的容器中的尺寸为66至600微米的玻璃珠研究混合。 使用两种不同的方法定性评估混合物的均匀性。 一种方法涉及透明混合容器，其中可以看到颗粒流动模式并且在整个实验期间评估其表面处混合物的状态。 第二种方法涉及一次性铝混合容器，其中混合物通过用粘合剂渗透混合物而固化。 通过切割凝固结构，可以在每个实验完成后评估包括其内部结构的混合物的整个状态。 使用片的图像分析也定量评估混合物的均匀性。 对于两种颗粒尺寸，与常规V型搅拌器相比，使用摇摆式V型搅拌器大大提高了混合程度。