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    保護剤
    4.
    发明申请
    保護剤 审中-公开
    保护剂

    公开(公告)号：WO2007126050A1

    公开(公告)日：2007-11-08

    申请号：PCT/JP2007/059161

    申请日：2007-04-27

    Applicant: 協和発酵ケミカル株式会社 ,  松岡 洋史 ,  沼崎 玲 ,  堀田 巌

    Inventor： 松岡 洋史 ,  沼崎 玲 ,  堀田 巌

    IPC: C07B51/00 ,  C07C49/175 ,  C07C323/12 ,  C08F8/00 ,  C08G8/28 ,  G03F7/039 ,  H01L21/027

    CPC classification number: C07C49/175 ,  C07B51/00 ,  C07C323/12 ,  G03F7/0392

    Abstract: Disclosed is a protective agent for a hydroxyl group or a carboxyl group, which is represented by the general formula (0) below (wherein X 1 represents a hydrogen atom and X 2 represents a halogen atom, or alternatively X 1 in combination with X 2 represent a bond; R 1 and R 2 independently represent a substituted or unsubstituted alkyl or the like; A represents an oxygen atom or a sulfur atom; and R 3 represents an alkyl wherein a group having an oxygen atom and/or a sulfur atom is substituted or the like). (0)

    Abstract translation: 公开了由下述通式（0）表示的羟基或羧基保护剂（其中X 1表示氢原子，X 2 O 2） 代表卤素原子，或者与X 2结合的X 1代表键; R 1和R 2 2 >独立地表示取代或未取代的烷基等; A表示氧原子或硫原子; R 3表示其中具有氧原子和/或硫原子的基团被取代的烷基 或类似物）。 （0）

    OXYGENATED ALIPHATIC COMPOUNDS AND THEIR USE AS INTERMEDIATES IN THE PREPARATION OF 4-HYDROXY-2,5-DIMETHYL-3(2H)-FURANONE
    7.
    发明申请
    OXYGENATED ALIPHATIC COMPOUNDS AND THEIR USE AS INTERMEDIATES IN THE PREPARATION OF 4-HYDROXY-2,5-DIMETHYL-3(2H)-FURANONE 审中-公开
    氧化的化合物及其作为制备4-羟基-2,5-二甲基-3（2H） - 呋喃酮的中间体

    公开(公告)号：WO1995007876A1

    公开(公告)日：1995-03-23

    申请号：PCT/IB1994000261

    申请日：1994-09-01

    Applicant: FIRMENICH S.A. ,  MIMOUN, Hubert ,  ZASLONA, Alexander ,  LERESCHE, Jean-Paul

    Inventor： FIRMENICH S.A.

    IPC: C07C43/14

    CPC classification number: C07C49/175 ,  C07C43/14 ,  C07C45/28 ,  C07C45/30 ,  C07C45/40

    Abstract: The compounds of the invention are characterized by formulae (II) and (III) wherein subscript p is the integer 2 or 3 and q can have the value zero or 1, provided that p+q=3. Said compounds are obtained from hex-3-yne-2,5-diol by a method consisting in reacting an ethylenic compound of formula (CH3)2C=C(H)n(CH3)m wherein subscript n is the integer 1 or 2 and m can have the value zero or 1 and wherein n+m=2, with hex-3-yne-2,5-diol, followed by oxydizing the acetylenic ether obtained by means of ruthenium tetroxyde. The compounds of formula (III) can be used as intermediates in the preparation of 4-hydroxy-2,5-dimethyl-3(2H)-furanone (Furaneol3).

    Abstract translation: 本发明的化合物的特征在于式（II）和（III），其中下标p是整数2或3，并且q可以具有0或1的值，条件是p + q = 3。 所述化合物由己-3-炔-2,5-二醇通过使式（CH 3）2 C = C（H）n（CH 3）m的烯属化合物反应，其中下标n为整数1或2 并且m可以具有0或1的值，并且其中n + m = 2，与己-3-炔-2,5-二醇，然后氧化通过四氧化钌获得的炔属醚。 式（III）化合物可用作制备4-羟基-2,5-二甲基-3（2H） - 呋喃酮（Furaneol 3）的中间体。

    PYRIDONE ESTERS AS INOTROPIC AGENTS
    8.
    发明申请
    PYRIDONE ESTERS AS INOTROPIC AGENTS 审中-公开
    作为无机物质的甜玉米饼

    公开(公告)号：WO1986001202A1

    公开(公告)日：1986-02-27

    申请号：PCT/US1985001468

    申请日：1985-08-01

    Applicant: AMERICAN HOSPITAL SUPPLY CORPORATION

    Inventor： AMERICAN HOSPITAL SUPPLY CORPORATION ,  STOUT, David, M. ,  YAMAMOTO, Diane, M. ,  BARCELON-YANG, Cynthia

    IPC: C07D213/62

    CPC classification number: C07D213/80 ,  C07C45/70 ,  C07C49/175 ,  C07D213/62 ,  C07D213/85 ,  C07D231/12 ,  C07D233/56 ,  C07D249/08 ,  C07D405/06 ,  C07D413/04

    Abstract: Compounds of formula (I) wherein R is hydrogen, lower alkyl, halo, cyano, hydroxy, amino, lower alkylamino, -CH2NH2, -CH2OH or -COOR''; R' is hydrogen, lower cycloalkyl or lower alkyl; R'' is lower alkenyl, lower alkynyl, lower cycloalkyl, -(W)nY wherein W is straight or branched chain lower alkyl or lower alkenyl, n is 0 to 5, and Y is Ar, lower cycloalkyl, lower alkenyl, lower alkynyl, -COOZ wherein Z is lower alkyl, a compound of formula (II), or NAB wherein A and B are, independently, lower alkyl, benzyl or substituted benzyl, and Ar is 2, 3 or 4-pyridyl, pyridazinyl, pyrimidinyl, quinolyl, isoquinolyl, phthalazinyl, quinazolinyl, thiazolyl, phenyl, benzyl, furyl, tetrahydrofuryl or thienyl, unsubstituted or substituted with lower alkyl, lower alkoxy, halo, amino, or -CF3; R''' is -COOR'', a compound of formulas (III) and X is oxygen or nitrogen; or a pharmaceutically acceptable salt thereof, and their use in the treatment of impaired ventricular myocardial contractility. The compounds exhibit cardiotonic activity.

    Abstract translation: 式（I）的化合物，其中R是氢，低级烷基，卤素，氰基，羟基，氨基，低级烷基氨基，-CH 2 NH 2，-CH 2 OH或-COOR“ R'是氢，低级环烷基或低级烷基; R“是低级烯基，低级炔基，低级环烷基， - （W）nY其中W是直链或支链低级烷基或低级烯基，n是0-5，Y是Ar，低级环烷基，低级烯基，低级炔基 ，其中Z为低级烷基的-COOZ，式（II）的化合物或NAB，其中A和B独立地为低级烷基，苄基或取代的苄基，Ar为2,3或4-吡啶基，哒嗪基，嘧啶基， 喹啉基，异喹啉基，酞嗪基，喹唑啉基，噻唑基，苯基，苄基，呋喃基，四氢呋喃基或噻吩基，未取代或被低级烷基，低级烷氧基，卤素，氨基或-CF 3取代。 R“是-COOR”，式（III）和X的化合物是氧或氮; 或其药学上可接受的盐，以及它们在治疗心室心肌收缩受损中的应用。 化合物表现出强心活性。

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