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    EXTREME PRESSURE ADDITIVE
    2.
    发明申请
    EXTREME PRESSURE ADDITIVE 审中-公开
    极压添加剂

    公开(公告)号：WO1998013442A1

    公开(公告)日：1998-04-02

    申请号：PCT/US1997017240

    申请日：1997-09-25

    Applicant: INTERNATIONAL LUBRICANTS INC.

    Inventor： INTERNATIONAL LUBRICANTS INC. ,  LANDIS, Phillip, S. ,  RHODES, Blaine, N. ,  WILLIAMSON, Will, F.

    IPC: C10M129/68

    CPC classification number: C10M137/105 ,  C07F9/4046 ,  C07F9/4075 ,  C10M2223/047

    Abstract: There is disclosed a lubricant additive ingredient that imparts extreme pressure anti-wear properties to lubricant additive compositions. Specifically, there is disclosed a derivative of a vegetable oil triglyceride, a wax ester or a telomerized oil reacted with phosphorous pentasulfide to produce a phosphorous-sulfur (PS) extreme pressure additive.

    Abstract translation: 公开了向润滑剂添加剂组合物赋予极压抗磨性能的润滑剂添加剂成分。 具体地，公开了与五硫化二磷反应产生磷 - 硫（PS）极压添加剂的植物油甘油三酯，蜡酯或调聚油的衍生物。

    BISPHOSPHONATE COMPOUNDS AND METHODS
    3.
    发明申请
    BISPHOSPHONATE COMPOUNDS AND METHODS 审中-公开
    二磷酸盐化合物和方法

    公开(公告)号：WO2007109585A3

    公开(公告)日：2008-11-06

    申请号：PCT/US2007064239

    申请日：2007-03-16

    Applicant: UNIV ILLINOIS ,  OLDFIELD ERIC ,  SONG YONGCHENG ,  ZHANG YONGHUI ,  SANDERS JOHN M

    Inventor： OLDFIELD ERIC ,  SONG YONGCHENG ,  ZHANG YONGHUI ,  SANDERS JOHN M

    IPC: A61K31/663 ,  C07F9/38 ,  C07F9/40

    CPC classification number: C07F9/4037 ,  C07F9/3843 ,  C07F9/3856 ,  C07F9/3865 ,  C07F9/3869 ,  C07F9/3873 ,  C07F9/4028 ,  C07F9/404 ,  C07F9/4046 ,  C07F9/5414 ,  C07F9/5728 ,  C07F9/581 ,  C07F9/65061 ,  C07F9/655345 ,  C07F9/655363 ,  C07F9/723

    Abstract: The invention provides, inter alia, novel bisphosphonate compounds and methods of making and using. In embodiments, the invention provides compounds and methods in connection with research and therapeutic applications, e.g., for tumor cell growth inhibition, activation of gammadelta T cells, inhibition of farnesyldiphosphate (FPPS) and/or undecaprenyldiphosphate synthase enzymes, bone resorption diseases, cancer, immune disorders, immunotherapy, and infectious diseases. In regards to certain embodiments, a surprising advance has been the recognition that certain structural features can significantly enhance the activity of the compounds. For example, the presence of particular cationic species e.g., phosphonium, sulfonium, and arsonium moieties can contribute to desirable functional activity when positioned near a bisphosphonate moiety. In other embodiments of non-nitrogen containing bisphosphonates, terphenyl and benzyl bisphosphonate compounds and methods are provided. Further variations are also provided.

    Abstract translation: 本发明尤其提供新的双膦酸盐化合物及其制备和使用方法。 在实施方案中，本发明提供了与研究和治疗应用相关的化合物和方法，例如用于肿瘤细胞生长抑制，Gammadelta T细胞的活化，法呢基二磷酸（FPPS）和/或十一烷基二磷酸合成酶的抑制，骨吸收疾病，癌症， 免疫疾病，免疫治疗和传染病。 关于某些实施方案，令人惊奇的进步是认识到某些结构特征可以显着增强化合物的活性。 例如，当位于二膦酸盐部分附近时，特定的阳离子物质例如鏻，锍和钍部分的存在可以有助于所需的功能活性。 在非含氮双膦酸盐的其它实施方案中，提供了三联苯基和苄基二膦酸盐化合物和方法。 还提供了进一步的变化。

    BISPHOSPHONATE COMPOUNDS AND METHODS
    4.
    发明申请
    BISPHOSPHONATE COMPOUNDS AND METHODS 审中-公开
    二磷酸盐化合物和方法

    公开(公告)号：WO2007109585A2

    公开(公告)日：2007-09-27

    申请号：PCT/US2007/064239

    申请日：2007-03-16

    Applicant: THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS ,  OLDFIELD, Eric ,  SONG, Yongcheng ,  ZHANG, Yonghui ,  SANDERS, John M.

    Inventor： OLDFIELD, Eric ,  SONG, Yongcheng ,  ZHANG, Yonghui ,  SANDERS, John M.

    IPC: A61K31/663

    CPC classification number: C07F9/4037 ,  C07F9/3843 ,  C07F9/3856 ,  C07F9/3865 ,  C07F9/3869 ,  C07F9/3873 ,  C07F9/4028 ,  C07F9/404 ,  C07F9/4046 ,  C07F9/5414 ,  C07F9/5728 ,  C07F9/581 ,  C07F9/65061 ,  C07F9/655345 ,  C07F9/655363 ,  C07F9/723

    Abstract: The invention provides, inter alia, novel bisphosphonate compounds and methods of making and using. In embodiments, the invention provides compounds and methods in connection with research and therapeutic applications, e.g., for tumor cell growth inhibition, activation of gammadelta T cells, inhibition of farnesyldiphosphate (FPPS) and/or undecaprenyldiphosphate synthase enzymes, bone resorption diseases, cancer, immune disorders, immunotherapy, and infectious diseases. In regards to certain embodiments, a surprising advance has been the recognition that certain structural features can significantly enhance the activity of the compounds. For example, the presence of particular cationic species e.g., phosphonium, sulfonium, and arsonium moieties can contribute to desirable functional activity when positioned near a bisphosphonate moiety. In other embodiments of non-nitrogen containing bisphosphonates, terphenyl and benzyl bisphosphonate compounds and methods are provided. Further variations are also provided.

    Abstract translation: 本发明尤其提供新的双膦酸盐化合物及其制备和使用方法。 在实施方案中，本发明提供了与研究和治疗应用相关的化合物和方法，例如用于肿瘤细胞生长抑制，Gammadelta T细胞的活化，法呢基二磷酸（FPPS）和/或十一烷基二磷酸合成酶的抑制，骨吸收疾病，癌症， 免疫疾病，免疫治疗和传染病。 关于某些实施方案，令人惊奇的进步是认识到某些结构特征可以显着增强化合物的活性。 例如，当位于二膦酸盐部分附近时，特定的阳离子物质例如鏻，锍和钍部分的存在可以有助于所需的功能活性。 在非含氮双膦酸盐的其它实施方案中，提供了三联苯基和苄基双膦酸盐化合物和方法。 还提供了进一步的变化。

    BIS-PHOSPHONATE CONFUGATES WITH ALKYLATING MOIETIES HAVING ANTITUMOR ACTIVITY
    9.
    发明申请
    BIS-PHOSPHONATE CONFUGATES WITH ALKYLATING MOIETIES HAVING ANTITUMOR ACTIVITY 审中-公开
    具有抗肿瘤活性的碱性化学物质的双磷酸盐

    公开(公告)号：WO98043987A1

    公开(公告)日：1998-10-08

    申请号：PCT/EP1998/001707

    申请日：1998-03-24

    IPC: C07F9/38 ,  C07F9/40 ,  A61K31/66

    CPC classification number: C07F9/3869 ,  C07F9/4046

    Abstract: The present invention relates to conjugates of 3-carboxy-4,4'-dihydroxyphosphorylbutenoic acids with alkylating agents. Such derivatives are endowed with marked antitumor activity, especially against multiple myeloma. The present invention relates as well to a process for the preparation thereof and to pharmaceutical compositions containing them.

    Abstract translation: 本发明涉及3-羧基-4,4'-二羟基磷酰基丁烯酸与烷基化剂的结合物。 这些衍生物具有明显的抗肿瘤活性，特别是针对多发性骨髓瘤。 本发明还涉及其制备方法和含有它们的药物组合物。

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