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    IMMUNOGEN ADHERENCE AND METHOD OF MAKING AND USING SAME
    3.
    发明申请
    IMMUNOGEN ADHERENCE AND METHOD OF MAKING AND USING SAME 审中-公开
    免疫学方法及其使用方法

    公开(公告)号：WO2011140550A2

    公开(公告)日：2011-11-10

    申请号：PCT/US2011035739

    申请日：2011-05-09

    申请人： CAMAS INC ,  MITTENESS BRADLEY M ,  PHILLIPS CONNIE

    发明人： MITTENESS BRADLEY M ,  PHILLIPS CONNIE

    IPC分类号： A61K39/395 ,  A61K9/12 ,  A61P11/00 ,  A61P31/00

    CPC分类号： A61K39/395 ,  C07K16/02

    摘要： A microbial adherence inhibitor in the form of fowl egg antibodies is disclosed, along with the method of making it and methods of using it. The inhibitor functions by substantially preventing the attachment of adherence of colony-forming immunogens in the respiratory tracts of host animals and humans. The inhibitor is made by inoculating female birds with the immunogen, harvesting the eggs which contain antibodies to the immunogen, and separating the yolk and albumin from the shells of the eggs. The yolk and albumin contents are administered to animals or human by distributing the contents directly or introducing the contents entrained in air. The adherence inhibiting material can be formulated for use in a variety of ways such as an oral spray or a nasal spray. These formulations can be effective to prevent or reduce respiratory illnesses in animals and humans.

    摘要翻译： 公开了禽蛋抗体形式的微生物粘附抑制剂及其制备方法及其使用方法。 抑制剂通过基本上防止宿主动物和人的呼吸道中附着集落形成免疫原的功能。 通过用免疫原接种雌性鸟类来收获抑制剂，收获含有针对免疫原的抗体的卵，并从蛋壳中分离蛋黄和白蛋白。 通过直接分配内容物或引入夹带在空气中的内容物将蛋黄和白蛋白内容物施用于动物或人类。 粘附抑制材料可以配制成以各种方式使用，例如口服喷雾或鼻喷雾剂。 这些制剂可有效预防或减少动物和人类的呼吸系统疾病。

    ANTI-GLUTEN EGG YOLK ANTIBODIES FOR THE TREATMENT OF CELIAC DISEASE
    6.
    发明申请
    ANTI-GLUTEN EGG YOLK ANTIBODIES FOR THE TREATMENT OF CELIAC DISEASE 审中-公开
    用于治疗慢性乙型肝炎的抗谷氨酸激素抗体

    公开(公告)号：WO2005099753A1

    公开(公告)日：2005-10-27

    申请号：PCT/CA2005/000593

    申请日：2005-04-18

    申请人： THE GOVENORS OF THE UNIVERSITY OF ALBERTA ,  SUNWOO, Hoon ,  SIM, Jeong S.

    发明人： SUNWOO, Hoon ,  SIM, Jeong S.

    IPC分类号： A61K39/395

    CPC分类号： C07K16/16 ,  A23L33/17 ,  A61K2039/505 ,  C07K16/02 ,  C07K2317/11

    摘要： Compositions, food products or beverages for ameliorating the syptoms of celiac disease or gluten sensitive enteropathy comprising egg yolk antibodies against gluten, including gliadin, high molecular glutenin, low molecular glutenin and mixtures of the three peptides. The antibodies may be produced by immunizing egg laying fowl with immunogenic preparations of gluten and harvesting the eggs and egg yolks.

    摘要翻译： 用于改善腹腔疾病或麸质敏感性肠病的组合物，食品或饮料，其包含针对麸质的蛋黄抗体，包括麦醇溶蛋白，高分子麦谷蛋白，低分子量麦谷蛋白和三种肽的混合物。 可以通过用鸡蛋和蛋黄的免疫原性制剂免疫产蛋鸡来产生抗体。

    IMMUNOGENE ADHERENCE AND METHOD OF MAKING AND USING THE SAME
    8.
    发明申请
    IMMUNOGENE ADHERENCE AND METHOD OF MAKING AND USING THE SAME 审中-公开
    免疫调节剂及其制备方法和使用方法

    公开(公告)号：WO2004073393A2

    公开(公告)日：2004-09-02

    申请号：PCT/US2004004623

    申请日：2004-02-17

    申请人： NASH PETER ,  MITTENESS BRADLEY M

    发明人： NASH PETER ,  MITTENESS BRADLEY M

    IPC分类号： C07K16/02 ,  C07K16/12 ,  C07K16/24 ,  C12P21/08 ,  A01K

    CPC分类号： C07K16/1242 ,  A61K2039/505 ,  C07K16/02 ,  C07K16/247

    摘要： A microbial adherence inhibitor in the form of fowl egg antibodies is disclosed, along with the method of making it and methods of using it. The inhibitor functions by substantially preventing the attachment of adherence of colony-forming immunogens in the respiratory tracts of host animals and humans. The inhibitor is made by inoculating female birds with the immunogen, harvesting the eggs which contain antibodies to the immunogen, and separating the yolk and albumin from the shells of the eggs. The yolk and albumin contents are administered to animals or human by distributing the contents directly or introducing the contents entrained in air.

    摘要翻译： 公开了禽蛋抗体形式的微生物粘附抑制剂及其制备方法及其使用方法。 抑制剂通过基本上防止宿主动物和人的呼吸道中附着集落形成免疫原的功能。 通过用免疫原接种雌性鸟类来收获抑制剂，收获含有针对免疫原的抗体的卵，并将蛋黄和白蛋白从卵壳中分离出来。 通过直接分配内容物或引入夹带在空气中的内容物将蛋黄和白蛋白内容物施用于动物或人类。

    IMMUNOGLOBULIN PURIFICATION
    9.
    发明申请
    IMMUNOGLOBULIN PURIFICATION 审中-公开
    免疫球蛋白纯化

    公开(公告)号：WO03065998A8

    公开(公告)日：2004-07-08

    申请号：PCT/US0303744

    申请日：2003-02-07

    申请人： TRANXENOGEN INC ,  RANSOHOFF THOMAS C ,  MURPHY OWEN J

    发明人： RANSOHOFF THOMAS C ,  MURPHY OWEN J

    IPC分类号： C07K16/00 ,  C07K16/02 ,  C07K16/44 ,  A61K39/395 ,  C07K1/00 ,  G01N33/53

    CPC分类号： C07K16/02 ,  C07K2317/21 ,  C07K2317/23

    摘要： The invention features compositions containing avian-derived transgenic non­avian antibodies and methods of recovering the compositions from transgenic avian eggs. Chromatographic techniques permit the purification of non-avain proteins produced in an avain tissue from contaminating avian tissue components for administration to humans.

    摘要翻译： 本发明的特征在于含有禽源性转基因非禽类抗体的组合物和从转基因禽蛋中回收组合物的方法。 色谱技术允许纯化鸟毒蛋白组织中产生的非灭活蛋白质，从污染的禽组织组分中提取给人类。

    TRANSGENIC AVES PRODUCING HUMAN POLYCLONAL ANTIBODIES
    10.
    发明申请
    TRANSGENIC AVES PRODUCING HUMAN POLYCLONAL ANTIBODIES 审中-公开
    转基因生产人类多克隆抗体

    公开(公告)号：WO03081993A2

    公开(公告)日：2003-10-09

    申请号：PCT/US0309288

    申请日：2003-03-24

    申请人： ORIGEN THERAPEUTICS

    发明人： ETCHES ROBERT J ,  KAY ROBERT M ,  LEIGHTON PHILIP ,  ZHU LEI

    IPC分类号： A01K67/027 ,  C07K14/705 ,  C07K16/02 ,  C12N5/06 ,  C12N15/85 ,  A01K

    CPC分类号： C07K16/461 ,  A01K67/0275 ,  A01K67/0278 ,  A01K2207/15 ,  A01K2217/00 ,  A01K2217/075 ,  A01K2227/30 ,  A01K2267/01 ,  C07K14/70503 ,  C07K16/02 ,  C07K2317/21 ,  C12N15/8509 ,  C12N2800/204 ,  C12N2800/30

    摘要： Human antibodies are produced in transgenic chickens having functional genetic components of the human immune system stably integrated in the genome. Techniques are described to integrate unrearranged human heavy and light chain immunoglobulin loci into the genome of the transgenic chicken. The functional description of the endogenous immunoglobulin loci yields an animal whose antibody repertoire in response to antigen is fully human. In the preferred embodiment, the human immunoglobulin locus is at least as large as the native human locus and exhibits functional class switching to yield IgG isotype antibodies. In addition to monoclonal antibodies secreted from immortalized B cell populations, polyclonal antibodies may be obtained from eggs laid by the transgenic chickens of the invention.

    摘要翻译： 在具有稳定整合在基因组中的人免疫系统的功能性遗传成分的转基因鸡中产生人抗体。 描述了将未经排列的人重链和轻链免疫球蛋白基因座整合到转基因鸡的基因组中的技术。 内源性免疫球蛋白基因座的功能描述产生一种抗体对抗原作出全部反应的动物。 在优选的实施方案中，人免疫球蛋白基因座至少与天然人基因座一样大，并显示功能类转换以产生IgG同种型抗体。 除了从永生化的B细胞群体分泌的单克隆抗体之外，多克隆抗体可以从本发明的转基因鸡放置的卵中获得。