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123 条记录 (耗时 0.023 秒)

    ALPHABODIES SPECIFICALLY BINDING TO VIRAL PROTEINS AND METHODS FOR PRODUCING THE SAME
    4.
    发明申请
    ALPHABODIES SPECIFICALLY BINDING TO VIRAL PROTEINS AND METHODS FOR PRODUCING THE SAME 审中-公开
    特异性绑定到病毒蛋白质的方法及其生产方法

    公开(公告)号：WO2012092971A1

    公开(公告)日：2012-07-12

    申请号：PCT/EP2011/050137

    申请日：2011-01-06

    申请人： COMPLIX NV ,  DESMET, Johan ,  LASTERS, Ignace ,  MEERSSEMAN, Geert ,  DEROO, Sabrina

    发明人： DESMET, Johan ,  LASTERS, Ignace ,  MEERSSEMAN, Geert ,  DEROO, Sabrina

    IPC分类号： C07K16/10 ,  C07K14/00

    CPC分类号： C07K16/08 ,  A61K39/00 ,  C07K16/1063 ,  C07K2317/92 ,  C07K2318/20 ,  G01N33/56988

    摘要： The invention provides methods for the production of single-chain Alphabody polypeptides having detectable binding affinity for, or detectable in vitro activity on, a viral protein of interest, which comprising the step of producing a single-chain Alphabody library comprising at least 100 different-sequence single-chain Alphabody polypeptides, wherein said Alphabody polypeptides differ from each other in at least one of a defined set of 5 to 20 variegated amino acid residue positions, and wherein said variegated amino acid residue positions are located at specific positions in one or more of the alpha-helices of the Alphabody or the linker fragment connecting two consecutive alpha-helices of the Alphabody polypeptides. The invention further provides Alphabodies obtainable by the methods of the invention and uses thereof.

    摘要翻译： 本发明提供了生产具有对感兴趣的病毒蛋白质具有可检测的结合亲和力或可检测的体外活性的单链阿拉伯糖苷多肽的方法，其包括产生包含至少100个不同序列的单链Alphabody文库的步骤， 序列单链Alphabody多肽，其中所述Alphabody多肽在限定的5至20个杂化氨基酸残基位置中的至少一个中彼此不同，并且其中所述杂色氨基酸残基位置位于一个或多个 的Alphabody的α-螺旋或连接Alphabody多肽的两个连续的α-螺旋的连接子片段。 本发明还提供了可通过本发明的方法获得的阿尔培布本及其用途。

    COVALENT DIABODIES AND USES THEREOF
    8.
    发明申请
    COVALENT DIABODIES AND USES THEREOF 审中-公开
    同性双胞胎及其用途

    公开(公告)号：WO2006113665A3

    公开(公告)日：2009-04-16

    申请号：PCT/US2006014481

    申请日：2006-04-17

    申请人： MACROGENICS INC ,  JOHNSON LESLIE S ,  HUANG LING

    发明人： JOHNSON LESLIE S ,  HUANG LING

    IPC分类号： A61K39/395 ,  C07H21/04 ,  C07K16/00 ,  C12P21/04 ,  C12P21/08

    CPC分类号： C07K16/283 ,  A61K2039/505 ,  C07K16/08 ,  C07K16/12 ,  C07K16/30 ,  C07K16/44 ,  C07K2317/24 ,  C07K2317/31 ,  C07K2317/34 ,  C07K2317/52 ,  C07K2317/53 ,  C07K2317/622 ,  C07K2317/626

    摘要： The present invention is directed to diabody molecules and uses thereof in the treatment of a variety of diseases and disorders, including immunological disorders, infectious disease, intoxication and cancers. The diabody molecules of the invention comprise two polypeptide chains that associate to form at least two epitope binding sites, which may recognize the same or different epitopes on the same or differing antigens. Additionally, the antigens may be from the same or different molecules. The individual polypeptide chains of the diabody molecule may be covalently bound through non-peptide bond covalent bonds, such as, but not limited to, disulfide bonding of cysteine residues located within each polypeptide chain. In particular embodiments, the diabody molecules of the present invention further comprise an Fc region, which allows antibody-like functionality to engineered into the molecule.

    摘要翻译： 本发明涉及双抗体分子及其在治疗各种疾病和病症（包括免疫学疾病，感染性疾病，中毒和癌症）中的用途。 本发明的双抗体分子包含两个缔合以形成至少两个表位结合位点的多肽链，其可识别相同或不同抗原上相同或不同的表位。 另外，抗原可以来自相同或不同的分子。 双抗体分子的单个多肽链可以通过非肽键共价键共价结合，例如但不限于位于每个多肽链内的半胱氨酸残基的二硫键。 在具体实施方案中，本发明的双抗体分子还包含Fc区，其允许将抗体样功能改造成分子。

    PREVENTION AND TREATMENT OF PORCINE REPRODUCTIVE AND RESPIRATORY SYNDROME (PRRS)
    9.
    发明申请
    PREVENTION AND TREATMENT OF PORCINE REPRODUCTIVE AND RESPIRATORY SYNDROME (PRRS) 审中-公开
    磷酸盐生殖与呼吸综合征（PRRS）的预防与治疗

    公开(公告)号：WO2007061281A2

    公开(公告)日：2007-05-31

    申请号：PCT/MX2006000131

    申请日：2006-11-22

    申请人： INVEST APLIC S A DE C V

    发明人： LUCIO DECANINI EDUARDO ,  MORALES GARZON JOSE ANDRES

    IPC分类号： A61K39/42 ,  C07K16/08

    CPC分类号： C07K16/10 ,  A61K2039/505 ,  C07K16/08 ,  C07K2317/11 ,  C07K2317/23

    摘要： The invention relates to the use of specific anti-PRRSV immunoglobulin compositions which are obtained from the egg yolk of hens hyperimmunised with the PRRS virus. The immunoglobulins are obtained by extracting the aqueous phase of the yolk through the use of hydroxypropyl methylcellulose phthalate at a final concentration of 0.05 % and 0.001 % sodium azide. The invention also relates to the oral and parenteral administration of said immunoglobulins for the prevention and treatment of pigs infected with the PRRS virus, in order to lower the mortality rates, obtain a weight gain and reduce viral excretion among herds.

    摘要翻译： 本发明涉及从用PRRS病毒超免疫的母鸡的蛋黄获得的特异性抗PRRSV免疫球蛋白组合物的用途。 通过使用最终浓度为0.05％和0.001％叠氮化钠的羟丙基甲基纤维素邻苯二甲酸酯萃取蛋黄水相而获得免疫球蛋白。 本发明还涉及用于预防和治疗感染PRRS病毒的猪的所述免疫球蛋白的口服和肠胃外给药，以便降低死亡率，获得体重增加并减少牛群中的病毒排泄。