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    QUATERNARY PHOSPHONIUM COATED SURFACES AND METHODS OF MAKING THE SAME
    5.
    发明申请
    QUATERNARY PHOSPHONIUM COATED SURFACES AND METHODS OF MAKING THE SAME 审中-公开
    第四代磷酸盐表面及其制备方法

    公开(公告)号：WO2016065358A1

    公开(公告)日：2016-04-28

    申请号：PCT/US2015/057374

    申请日：2015-10-26

    Applicant: ORTHOBOND, INC.

    Inventor： CLEVENGER, Randy ,  SE-HO, Kim

    IPC: B32B17/06

    CPC classification number: C08F292/00 ,  C08F230/02 ,  C08F2438/01 ,  C08J7/16 ,  C09D5/14

    Abstract: Disclosed herein is a composition comprising a substrate with functionalized surface covalently bound to an anti-infective agent, such as a quaternary phosphonium compound with anti-bacterial activity against a broad range of bacteria, methods of synthesizing an anti-infective composition, and its resultant antimicrobial performance.

    Abstract translation: 本文公开了一种组合物，其包含具有与抗感染剂共价结合的官能化表面的底物，例如对广泛细菌具有抗细菌活性的季鏻化合物，合成抗感染组合物的方法及其结果 抗菌性能。

    SEPARATING AGENT
    6.
    发明申请
    SEPARATING AGENT 审中-公开
    分离剂

    公开(公告)号：WO2015005361A9

    公开(公告)日：2015-11-12

    申请号：PCT/JP2014068237

    申请日：2014-07-08

    Applicant: NAT UNIV CORP KYOTO INST TECH ,  DAICEL CORP

    Inventor： IKEGAMI TOHRU ,  KAWACHI YUSUKE ,  KUNISAWA AKIHIRO

    IPC: G01N30/88 ,  B01J20/26 ,  C08F20/56 ,  C08F20/58 ,  C08F20/60

    CPC classification number: C08F292/00 ,  B01D15/305 ,  B01J20/286 ,  B01J20/289 ,  B01J20/3204 ,  B01J20/327 ,  B01J2220/82 ,  C08F20/54 ,  C08F20/60 ,  C08F2220/585 ,  C08F220/60 ,  C08F230/08

    Abstract: The problem addressed by the present invention is to provide a novel separating agent for hydrophilic interaction chromatography useful in separating hydrophilic compounds. The hydrophilic interaction chromatography separating agent, which is formed from a carrier and a ligand carried by the carrier, is a separating agent wherein the ligand is a (meth)acrylic polymer having a constituent unit derived from the compound indicated by formula (I). (In formula (I): there are one or two double bonds between atoms configuring a heterocycle; X1 is selected from the group consisting of S, SCH3 +, O, NH, NCH3, CH2, CHR, and CR1R2; and X2, X3, and X4 are each selected from the group consisting of N, NH, NCH3, CH2, CHR, NCH3 +, CH, CR, and CR1R2. R1 and R2 are each a substituted or unsubstituted alkyl having 1-18 carbon atoms, an aryl having 6-18 carbon atoms, an alkenyl having 2-18 carbon atoms, an alkynyl having 2-18 carbon atoms, an aralkyl having 7-18 carbon atoms, an acyl having 2-18 carbon atoms, a cycloalkyl having 3-18 carbon atoms, a carboxyl, an amino, an aryloxy having 6-18 carbon atoms, an alkoxy having 1-18 carbon atoms, a halo, a hydroxy, a nitro, or a cyano. R is a substituted or unsubstituted alkyl having 1-18 carbon atoms, an aryl having 6-18 carbon atoms, an alkenyl having 2-18 carbon atoms, an alkynyl having 2-18 carbon atoms, an aralkyl having 7-18 carbon atoms, an acyl having 2-18 carbon atoms, a cycloalkyl having 3-18 carbon atoms, a carboxyl, an amino, an aryloxy having 6-18 carbon atoms, an alkoxy having 1-18 carbon atoms, a halo, a hydroxy, a nitro, or a cyano. At least two of X1, X2, X3, and X4 are not CH2, CH, CR, or CR1R2, and R3 is H or CH3.)

    Abstract translation: 本发明解决的问题是提供一种用于分离亲水化合物的亲水相互作用层析的新型分离剂。 由载体和由载体携带的配位体形成的亲水相互作用层析分离剂是分离剂，其中配体是具有衍生自由式（I）表示的化合物的结构单元的（甲基）丙烯酸聚合物。 （式（I）中：构成杂环的原子之间有一个或两个双键; X1选自S，SCH3 +，O，NH，NCH3，CH2，CHR和CR1R2; X2，X3 ，X4分别选自N，NH，NCH 3，CH 2，CHR，NCH 3 +，CH，CR和CR 1 R 2，R 1和R 2各自为具有1-18个碳原子的取代或未取代的烷基， 具有6-18个碳原子，具有2-18个碳原子的烯基，具有2-18个碳原子的炔基，具有7-18个碳原子的芳烷基，具有2-18个碳原子的酰基，具有3-18个碳原子的环烷基 原子，羧基，氨基，具有6-18个碳原子的芳氧基，具有1-18个碳原子的烷氧基，卤素，羟基，硝基或氰基。R是具有1-18个碳原子的取代或未取代的烷基 碳原子，具有6-18个碳原子的芳基，具有2-18个碳原子的烯基，具有2-18个碳原子的炔基，具有7-18个碳原子的芳烷基，具有2-18个碳原子的酰基，环烷基 有3 -18个碳原子，羧基，氨基，具有6-18个碳原子的芳氧基，具有1-18个碳原子的烷氧基，卤素，羟基，硝基或氰基。 X1，X2，X3和X4中的至少两个不是CH2，CH，CR或CR1R2，R3是H或CH3。

    A HARDENABLE MULTI-PART ACRYLIC COMPOSITION
    8.
    发明申请
    A HARDENABLE MULTI-PART ACRYLIC COMPOSITION 审中-公开
    一种可能的多部分丙烯酸酯组合物

    公开(公告)号：WO2015044689A1

    公开(公告)日：2015-04-02

    申请号：PCT/GB2014/052950

    申请日：2014-09-30

    Applicant: LUCITE INTERNATIONAL UK LIMITED ,  LUCITE INTERNATIONAL SPECIALITY POLYMERS & RESINS LIMITED

    Inventor： CHISHOLM, Michael Stephen ,  ABED-ALI, Sera Saheb

    IPC: A61L27/16 ,  A61L27/50 ,  A61L24/00 ,  A61L24/06 ,  C08F265/06 ,  C08L33/12

    CPC classification number: A61L24/06 ,  A61K6/0835 ,  A61L24/001 ,  A61L27/16 ,  A61L27/50 ,  A61L2430/02 ,  C08F265/06 ,  C08F292/00 ,  C08K3/30 ,  C08K2003/3045 ,  C08L33/12 ,  C08L33/14 ,  C08F220/14 ,  C08L33/08

    Abstract: The invention relates to a hardenable multi-part liquid acrylic composition. The composition comprises a storage stable liquid first part, a storage stable liquid second part and optionally, a third or further liquid parts. The parts are operable to form a cement which hardens to a solid upon mixing of the parts together. The composition comprises an acrylic monomer component, an initiator component,acrylic polymer particles and a radiopacifying filler. The initiator component is present in an amount effective topolymerize the acrylic monomer component upon being mixed and/or activated therewith. At least some of the radiopacifying filler is encapsulated within and/or adsorbed on the acrylic polymer particles in a liquid part. The invention extends to an at least twin barreled syringe or caulking gun accommodating the multi-part composition, a method of producing the multi-part composition, a composition for use as bone cement composition or in dental repairs, a liquid composition comprising a first sub-population of emulsion or non-emulsion polymerized acrylic polymer particles and radiopacifying filler encapsulated and/or adsorbed in the first sub-population of acrylic polymer particles and bone cement compositions or dental compositions.

    Abstract translation: 本发明涉及一种可硬化的多部分液体丙烯酸组合物。 该组合物包括储存稳定的液体第一部分，储存稳定的液体第二部分和任选的第三或另外的液体部分。 这些部件可操作以形成在将部件混合在一起之后固化成固体的水泥。 该组合物包含丙烯酸单体组分，引发剂组分，丙烯酸聚合物颗粒和放射性填料。 引发剂组分以与丙烯酸单体组分混合和/或活化之后有效地将聚合丙烯酸单体组分的量存在。 至少一些放射性填料填料被包封在和/或吸附在液体部分的丙烯酸类聚合物颗粒上。 本发明延伸到容纳多部分组合物的至少双管筒注射器或填缝枪，制备多部分组合物的方法，用作骨水泥组合物或牙科修复中的组合物，液体组合物，其包含第一子 乳液或非乳液聚合的丙烯酸类聚合物颗粒和包封和/或吸附在丙烯酸类聚合物颗粒和骨水泥组合物或牙科组合物的第一亚种群中的放射性填料填料。

    PERSISTENT CARBENES AND RELATED COMPOSITIONS
    9.
    发明申请
    PERSISTENT CARBENES AND RELATED COMPOSITIONS 审中-公开
    耐久性及相关成分

    公开(公告)号：WO2014160471A3

    公开(公告)日：2014-11-20

    申请号：PCT/US2014026752

    申请日：2014-03-13

    Applicant: MASSACHUSETTS INST TECHNOLOGY

    Inventor： JOHNSON JEREMIAH A ,  ZHUKHOVITSKIY ALEKSANDR V

    IPC: C08G61/08 ,  C07D247/00

    CPC classification number: C07D233/20 ,  C07D233/06 ,  C07D403/10 ,  C07D403/14 ,  C08F292/00

    Abstract: Articles and methods comprising persistent carbenes are provided, as well as related compositions. In some embodiments, a persistent carbene may be associated with a portion of a substrate (e.g., at least a portion of a surface on the substrate). In certain embodiments, the association of persistent carbene with the substrate may be used to affect certain properties of substrate (e.g., surface chemistry, stability). In some cases, a persistent carbene may be functionalized after association with a portion of a substrate. In some embodiments, a persistent carbene and at least one secondary compound may be associated with a portion of a substrate. Articles and methods of the present invention may be useful for applications involving electronics, sensing, microfabrication, nanotechnology, biomimetic, and drug delivery, amongst others.

    Abstract translation: 提供了包含持续卡宾的制品和方法以及相关组合物。 在一些实施方案中，持久卡宾可以与基底的一部分（例如，基底上的表面的至少一部分）相关联。 在某些实施方案中，持久卡宾与底物的缔合可用于影响底物的某些性质（例如表面化学，稳定性）。 在一些情况下，持续卡宾可以在与一部分底物缔合后进行官能化。 在一些实施方案中，持久卡宾和至少一种次要化合物可与底物的一部分缔合。 本发明的制品和方法可用于涉及电子学，感测，微细加工，纳米技术，仿制和药物递送等应用。

    ARTICLES AND METHODS COMPRISING PERSISTENT CARBENES AND RELATED COMPOSITIONS
    10.
    发明申请
    ARTICLES AND METHODS COMPRISING PERSISTENT CARBENES AND RELATED COMPOSITIONS 审中-公开
    包含耐久性碳和相关组合物的文章和方法

    公开(公告)号：WO2014160471A2

    公开(公告)日：2014-10-02

    申请号：PCT/US2014/026752

    申请日：2014-03-13

    Applicant: MASSACHUSETTS INSTITUTE OF TECHNOLOGY

    Inventor： JOHNSON, Jeremiah, A. ,  ZHUKHOVITSKIY, Aleksandr, V.

    IPC: C07D233/20 ,  C07D403/14 ,  C07D403/10

    CPC classification number: C07D233/20 ,  C07D233/06 ,  C07D403/10 ,  C07D403/14 ,  C08F292/00

    Abstract: Articles and methods comprising persistent carbenes are provided, as well as related compositions. In some embodiments, a persistent carbene may be associated with a portion of a substrate (e.g., at least a portion of a surface on the substrate). In certain embodiments, the association of persistent carbene with the substrate may be used to affect certain properties of substrate (e.g., surface chemistry, stability). In some cases, a persistent carbene may be functionalized after association with a portion of a substrate. In some embodiments, a persistent carbene and at least one secondary compound may be associated with a portion of a substrate. Articles and methods of the present invention may be useful for applications involving electronics, sensing, microfabrication, nanotechnology, biomimetic, and drug delivery, amongst others.

    Abstract translation: 提供了包含持续卡宾的制品和方法以及相关组合物。 在一些实施方案中，持久卡宾可以与基底的一部分（例如，基底上的表面的至少一部分）相关联。 在某些实施方案中，持久卡宾与底物的缔合可用于影响底物的某些性质（例如表面化学，稳定性）。 在一些情况下，持续卡宾可以在与一部分底物缔合后进行官能化。 在一些实施方案中，持久卡宾和至少一种次级化合物可与底物的一部分缔合。 本发明的制品和方法可用于涉及电子学，感测，微细加工，纳米技术，仿制和药物递送等应用。

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