公开(公告)号：WO2016053758A1

公开(公告)日：2016-04-07

申请号：PCT/US2015/052029

申请日：2015-09-24

Applicant: COMMENCE BIO, INC.

Inventor： BETANCOURT, Aline

IPC: C12N5/00 ,  C12N5/02 ,  A01N63/00

CPC classification number: C12N5/0043 ,  A61K35/28 ,  A61K2035/124 ,  C12N5/0662 ,  C12N5/0663 ,  C12N5/0668 ,  C12N2500/02 ,  C12N2500/92 ,  C12N2501/00 ,  C12N2501/052 ,  C12N2501/14 ,  C12N2501/22 ,  C12N2501/2304 ,  C12N2501/2313 ,  C12N2501/24 ,  C12N2501/25 ,  C12N2501/58 ,  C12N2501/599 ,  C12N2501/90 ,  C12N2501/999

Abstract: Novel MSC stem-cell culture and therapy methods and culture medium compositions for the purpose of inducing, activating, or priming discrete uniform cell phenotypes to selectively promote or suppress inflammation and immunity, yielding polarized, primed, activated, or induced cells used in cell-based therapy.

Abstract translation: 新型MSC干细胞培养和治疗方法和培养基组合物，用于诱导，激活或引发离散的均匀细胞表型以选择性地促进或抑制炎症和免疫，产生用于细胞周期的极化的，引发的，活化的或诱导的细胞， 基于治疗。

公开(公告)号：WO2017024213A1

公开(公告)日：2017-02-09

申请号：PCT/US2016/045739

申请日：2016-08-05

Applicant: REGENTS OF THE UNIVERSITY OF MINNESOTA ,  BLAZAR, Bruce R. ,  KOEHN, Brent H. ,  MURRAY, Peter J. ,  TING, Jenny P. Y. ,  ZEISER, Robert ,  MILLER, Jeff S.

Inventor： BLAZAR, Bruce R. ,  KOEHN, Brent H. ,  MURRAY, Peter J. ,  TING, Jenny P. Y. ,  ZEISER, Robert ,  MILLER, Jeff S.

IPC: A61K35/15 ,  C12N5/078 ,  C12N15/00 ,  A61P37/06

CPC classification number: A61K35/15 ,  A61K2035/122 ,  A61K2035/124 ,  C12N5/0642 ,  C12N5/0648 ,  C12N2501/22 ,  C12N2501/2313

Abstract: In one aspect, a method of treating a subject having or at risk of having graft-versus-host disease (GvHD) generally includes administering to the subject a plurality of myeloid-derived suppressor cells (MDSCs) effective to ameliorate at least one symptom or clinical sign of graft- versus-host disease compared to a suitable control subject. In another aspect, a method of treating a tumor in a subject generally includes administering to the subject an anti-tumor therapy and co-administering to the subject an inflammasome inciting agent in an amount effective to increase inflammasome activation of MDSCs sufficiently to reduce suppressor function of the MDSCs.

Abstract translation: 在一个方面，治疗患有或具有移植物抗宿主病（GvHD）风险的受试者的方法通常包括向受试者施用有效改善至少一种症状的多种骨髓来源的抑制细胞（MDSC）或 与合适的对照受试者相比，移植物抗宿主病的临床症状。 在另一方面，治疗受试者肿瘤的方法通常包括向受试者施用抗肿瘤治疗，并以有效增加MDSC的炎性体活化的量足以降低抑制功能的量向受试者共同施用炎症体征煽动剂 的MDSCs。

公开(公告)号：WO2014190866A1

公开(公告)日：2014-12-04

申请号：PCT/CN2014/077952

申请日：2014-05-21

Applicant: 中国科学院上海生命科学研究院

Inventor： 胡苹 ,  傅鑫 ,  肖俊

IPC: C12N5/074 ,  A61K35/34 ,  A61P21/00

CPC classification number: C12N5/0659 ,  A61K35/34 ,  C12N2501/20 ,  C12N2501/21 ,  C12N2501/22 ,  C12N2501/2301 ,  C12N2501/2303 ,  C12N2501/231 ,  C12N2501/2313 ,  C12N2501/2316 ,  C12N2501/2317 ,  C12N2501/24 ,  C12N2501/25 ,  C12N2502/1114

Abstract: 提供了一种肌肉干细胞体外培养方法，即采用添加有血液细胞的细胞因子的细胞培养基或血液细胞的条件培养基体外培养肌肉干细胞。还提供了所述肌肉干细胞体外培养方法所用的培养基及其应用。

公开(公告)号：WO2014127276A1

公开(公告)日：2014-08-21

申请号：PCT/US2014/016562

申请日：2014-02-14

Applicant: IMMUNOCELLULAR THERAPEUTICS, LTD. ,  CEDARS-SINAI MEDICAL CENTER

Inventor： YU, John, S. ,  ZHENHUA, Li ,  ORSULIC, Sandra ,  KARLAN, Beth, Y. ,  BENDER, James, G.

IPC: A61K39/00 ,  A61P35/00

CPC classification number: A61K39/0011 ,  A61K31/675 ,  A61K45/06 ,  A61K2039/5154 ,  A61K2039/585 ,  A61K2039/70 ,  C12N5/0639 ,  C12N2501/11 ,  C12N2501/22 ,  C12N2501/2304 ,  C12N2501/2313 ,  C12N2501/25 ,  C12N2501/48 ,  C12N2501/50 ,  C12N2501/599 ,  C12N2501/727 ,  C12N2501/998 ,  C12N2506/115

Abstract: Compositions of multipeptide vaccines including tumor associated antigens, compositions of antigen presenting cell (e.g., dendritic cell) based vaccines presenting epitopes from tumor associated antigens, and methods of making same, are provided herein. Also, disclosed are methods for treating ovarian cancers using such vaccines.

Abstract translation: 本文提供了多肽疫苗的组合物，包括肿瘤相关抗原，呈递来自肿瘤相关抗原的表位的抗原呈递细胞（例如树突状细胞）疫苗的组合物及其制备方法。 还公开了使用这种疫苗治疗卵巢癌的方法。