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    METHODS FOR INDUCING PARTIAL APOPTOSIS USING CASPASE POLYPEPTIDES
    1.
    发明申请
    METHODS FOR INDUCING PARTIAL APOPTOSIS USING CASPASE POLYPEPTIDES 审中-公开
    用CASPASE多糖诱导部分病变的方法

    公开(公告)号：WO2014197638A3

    公开(公告)日：2015-02-05

    申请号：PCT/US2014040964

    申请日：2014-06-04

    Applicant: BELLICUM PHARMACEUTICALS INC

    Inventor： SLAWIN KEVIN ,  SPENCER DAVID ,  FOSTER AARON EDWARD

    IPC: C12N5/00

    CPC classification number: A61K38/4873 ,  A61K35/17 ,  A61K35/28 ,  A61K35/30 ,  A61K35/545 ,  A61K38/16 ,  A61K38/177 ,  A61K39/0005 ,  A61K48/005 ,  C12N5/0081 ,  C12N5/0087 ,  C12N9/6472 ,  C12N2501/48 ,  C12N2510/00

    Abstract: The technology relates in part to methods for inducing partial apoptosis of cells that express an inducible caspase polypeptide. The technology further relates in part to methods for inducing partial apoptosis of cells that express an inducible modified caspase polypeptide, having a modified dose response curve to the multimeric ligand inducer. The technology also relates in part to methods for cell therapy using cells that express the inducible caspase polypeptide or the inducible modified caspase polypeptide, where the proportion of caspase polypeptide-expressing cells eliminated by apoptosis is related to the administered amount of the multimeric ligand inducer.

    Abstract translation: 该技术部分涉及诱导表达诱导型半胱天冬酶多肽的细胞的部分凋亡的方法。 该技术还部分涉及诱导表达可诱导的修饰的半胱天冬酶多肽的细胞的部分凋亡的方法，其具有对多聚体配体诱导物的修饰的剂量反应曲线。 该技术还部分地涉及使用表达可诱导半胱天冬酶多肽的细胞的细胞疗法的方法或可诱导的修饰的半胱天冬酶多肽，其中通过凋亡消除的半胱天冬酶多肽表达细胞的比例与多聚体配体诱导剂的施用量有关。

    METHODS FOR INDUCING PARTIAL APOPTOSIS USING CASPASE POLYPEPTIDES
    2.
    发明申请
    METHODS FOR INDUCING PARTIAL APOPTOSIS USING CASPASE POLYPEPTIDES 审中-公开
    用CASPASE多糖诱导部分病变的方法

    公开(公告)号：WO2014197638A2

    公开(公告)日：2014-12-11

    申请号：PCT/US2014/040964

    申请日：2014-06-04

    Applicant: BELLICUM PHARMACEUTICALS, INC.

    Inventor： SLAWIN, Kevin ,  SPENCER, David ,  FOSTER, Aaron, Edward

    IPC: A61K48/00 ,  C12N15/85

    CPC classification number: A61K38/4873 ,  A61K35/17 ,  A61K35/28 ,  A61K35/30 ,  A61K35/545 ,  A61K38/16 ,  A61K38/177 ,  A61K39/0005 ,  A61K48/005 ,  C12N5/0081 ,  C12N5/0087 ,  C12N9/6472 ,  C12N2501/48 ,  C12N2510/00

    Abstract: The technology relates in part to methods for inducing partial apoptosis of cells that express an inducible caspase polypeptide. The technology further relates in part to methods for inducing partial apoptosis of cells that express an inducible modified caspase polypeptide, having a modified dose response curve to the multimeric ligand inducer. The technology also relates in part to methods for cell therapy using cells that express the inducible caspase polypeptide or the inducible modified caspase polypeptide, where the proportion of caspase polypeptide-expressing cells eliminated by apoptosis is related to the administered amount of the multimeric ligand inducer.

    Abstract translation: 该技术部分涉及诱导表达诱导型半胱天冬酶多肽的细胞的部分凋亡的方法。 该技术还部分涉及诱导表达可诱导的修饰的半胱天冬酶多肽的细胞的部分凋亡的方法，其具有对多聚体配体诱导物的修饰的剂量反应曲线。 该技术还部分地涉及使用表达可诱导半胱天冬酶多肽的细胞的细胞疗法的方法或可诱导的修饰的半胱天冬酶多肽，其中通过凋亡消除的半胱天冬酶多肽表达细胞的比例与多聚体配体诱导剂的施用量有关。

    조혈세포 분화 유도 방법
    5.
    发明申请
    조혈세포 분화 유도 방법 审中-公开
    诱导HEMOBLAST差异的方法

    公开(公告)号：WO2014042432A1

    公开(公告)日：2014-03-20

    申请号：PCT/KR2013/008226

    申请日：2013-09-11

    Applicant: 한양대학교 산학협력단

    Inventor： 백은정 ,  이은미

    IPC: C12N5/078 ,  C12N5/02 ,  A61K35/14

    CPC classification number: C12N5/0641 ,  A61K35/15 ,  A61K35/18 ,  A61K38/1709 ,  C12N5/0642 ,  C12N2500/99 ,  C12N2501/125 ,  C12N2501/14 ,  C12N2501/2303 ,  C12N2501/48 ,  C12N2501/998 ,  C12N2506/025 ,  C12N2506/11

    Abstract: 본 발명은 조혈세포 분화 유도 방법을 이용한 인 비트로 적혈구/과립구 생산 및 골수이형성 증후군 치료에 관한 것으로, 겔솔린(gelsolin)을 유효성분으로 포함하는 조혈전구세포로부터 적혈구/과립구로의 분화를 유도하기 위한 배지 조성물 및 겔솔린(gelsolin)을 유효성분으로 포함하는 골수이형성 증후군 치료용 약학적 조성물을 제공한다. 본 발명의 조성물은 조혈전구세포의 적혈구/과립구로의 분화 효율을 향상시키면서도 세포이형성증 발생률이 낮고, 탈핵률 및 세포생존률이 향상되는 효과가 있는 바, 체외 적혈구/과립구 생산 및 골수이형성 증후군 치료에 유용하게 이용될 수 있다.

    Abstract translation: 本发明涉及使用诱导成血细胞分化的方法体外生产红细胞/粒细胞和治疗骨髓增生异常综合征。 本发明提供了含有凝溶胶蛋白作为诱导将造血前体细胞分化为红细胞/粒细胞的活性成分的媒体组合物，以及含有凝溶胶蛋白作为治疗骨髓增生异常综合征的活性成分的药物组合物。 由于本发明的组合物提高了造血前体细胞分化为红细胞/粒细胞的效率，同时保持细胞发育不良的发生率低，并且具有提高摘除率和细胞存活率的效果，因此本发明可以有效地使用 用于在体外产生红细胞/粒细胞并用于治疗骨髓增生异常综合征。

    METHODS FOR INDUCING THE DIFFERENTIATION OF BLOOD MONOCYTES INTO FUNCTIONAL DENDRITIC CELLS
    8.
    发明申请
    METHODS FOR INDUCING THE DIFFERENTIATION OF BLOOD MONOCYTES INTO FUNCTIONAL DENDRITIC CELLS 审中-公开
    诱导血液单核细胞分化为功能性树突状细胞的方法

    公开(公告)号：WO2009108738A2

    公开(公告)日：2009-09-03

    申请号：PCT/US2009035210

    申请日：2009-02-26

    Applicant: UNIV YALE ,  EDELSON RICHARD LESLIE ,  BERGER CAROLE L

    Inventor： EDELSON RICHARD L ,  BERGER CAROLE L

    IPC: A61K35/00 ,  A61K35/14 ,  A61K39/00

    CPC classification number: C12N5/0639 ,  C12N2500/02 ,  C12N2501/48 ,  C12N2501/998 ,  C12N2502/11 ,  C12N2506/11

    Abstract: Methods are provided for inducing differentiation of blood monocytes into functional antigen presenting dendritic cells. The blood monocytes are treated by exposing the monocytes to proteins adhered to the surface of a treatment device to induce differentiation of the monocytes in to dendritic cells. The treated monocytes may be co-incubated with disease effector agents which have been rendered apoptotic or other source of antigens. The apoptotic disease effector cells are phagocytized by the maturing dendritic cells, hi a preferred embodiment, the blood monocytes are treated in the plastic device without use of a photoactivatable agent and light.

    Abstract translation: 提供了诱导血液单核细胞分化为功能性抗原呈递树突细胞的方法。 通过将单核细胞暴露于附着于治疗装置表面的蛋白质以诱导单核细胞分化为树突细胞来处理血液单核细胞。 处理过的单核细胞可以与已经发生凋亡或其它抗原来源的疾病效应剂共温育。 凋亡疾病效应细胞被成熟的树突细胞吞噬。在优选的实施方案中，在塑料装置中处理血液单核细胞而不使用可光活化剂和光。

    PEROXISOME PROLIFERATOR-ACTIVATOR RECEPTOR DELTA (PPAR DELTA) AND THE DEVELOPMENT OF PREIMPLANTATION EMBRYOS
    9.
    发明申请
    PEROXISOME PROLIFERATOR-ACTIVATOR RECEPTOR DELTA (PPAR DELTA) AND THE DEVELOPMENT OF PREIMPLANTATION EMBRYOS 审中-公开
    过氧化物酶促反应物 - 激活剂受体三角菌（PPAR DELTA）和预防胚胎发育

    公开(公告)号：WO2007047341A3

    公开(公告)日：2009-03-26

    申请号：PCT/US2006039842

    申请日：2006-10-12

    Applicant: UNIV TEXAS ,  HUANG JAOU-CHEN ,  WUN ALFRED W-S ,  GOLDSBY JENNIFER ,  WU KENNETH K

    Inventor： HUANG JAOU-CHEN ,  WUN ALFRED W-S ,  GOLDSBY JENNIFER ,  WU KENNETH K

    IPC: C12N5/00 ,  C12N5/073

    CPC classification number: C07K14/705 ,  A01K2217/075 ,  A01K2267/03 ,  C12N5/0604 ,  C12N2501/02 ,  C12N2501/385 ,  C12N2501/48

    Abstract: Methods and compositions for enhancing development of a preimplantation mammalian embryo and for increasing the live birth potential of an in vitro fertilized mammalian embryo are disclosed. An in vitro method of activating the peroxisome proliferator activator receptor d (PPARd) in a preimplantation mammalian embryo comprises culturing an embryo in an embryo culture medium, and upon or after commencement of expression of PPARd in the cells of the embryo, activating the PPARd by adding an amount of a PPARd ligand to said medium effective to bind to PPARd to deter apoptosis in the cells of the cultured embryo and/or increase proliferation of the cells of the cultured embryo.

    Abstract translation: 公开了用于增强植入前哺乳动物胚胎发育和增加体外受精哺乳动物胚胎的活胎发生潜力的方法和组合物。 在植入前的哺乳动物胚胎中激活过氧化物酶体增殖物激活受体d（PPARd）的体外方法包括在胚胎培养基中培养胚胎，并且在胚胎细胞中表达PPARd之后或之后，通过以下步骤激活PPARd： 向所述培养基中加入一定量的PPARd配体，其有效结合PPARd以阻止培养的胚胎细胞中的凋亡和/或增加培养的胚胎细胞的增殖。

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