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    COMPOSITIONS AND METHODS FOR CELL TARGETED HPV TREATMENT
    4.
    发明申请
    COMPOSITIONS AND METHODS FOR CELL TARGETED HPV TREATMENT 审中-公开
    细胞靶向HPV治疗的组合物和方法

    公开(公告)号：WO2016196282A1

    公开(公告)日：2016-12-08

    申请号：PCT/US2016/034627

    申请日：2016-05-27

    Applicant: AGENOVIR CORPORATION

    Inventor： QUAKE, Stephen, R. ,  WANG, Jianbin

    IPC: A61K38/46 ,  A61K31/7105 ,  C12N9/22 ,  C12N15/63

    CPC classification number: A61K38/465 ,  A61K9/127 ,  A61K31/7105 ,  C07K2319/01 ,  C07K2319/85 ,  C12N9/22 ,  C12Y301/00

    Abstract: The invention provides compositions and methods for treating human papillomavirus (HPV) infections using a targetable nuclease, which compositions and methods can be used to selectively target the HPV genome or selectively express the targetable nuclease within cells that infected by HPV. By selectively targeting cells infected by HPV, the HPV genome within infected cells, or both, the nuclease is able to cleave the HPV genome thereby inactivating it and rendering it inoperable, interfering with the virus's ability to propagate even where the virus is in a latent stage of infection. Since latent HPV can be cleaved and eradicated from the host cells, compositions and methods of the invention may be used to treat HPV infections and potentially prevent many of the adverse health consequences associated with the papillomavirus.

    Abstract translation: 本发明提供使用可靶向核酸酶处理人乳头瘤病毒（HPV）感染的组合物和方法，该组合物和方法可用于选择性靶向HPV基因组或在HPV感染的细胞内选择性表达可靶向核酸酶。 通过选择性靶向感染HPV的细胞，感染细胞或两者的HPV基因组核酸酶能够切割HPV基因组，从而使其失活并使其无法操作，干扰病毒传播的能力，甚至病毒处于潜伏期 感染阶段 由于可以从宿主细胞中切割并根除潜伏的HPV，所以本发明的组合物和方法可用于治疗HPV感染并潜在地预防与乳头瘤病毒相关的许多不良健康后果。

    NANOS KNOCK-OUT THAT ABLATES GERMLINE CELLS
    7.
    发明申请
    NANOS KNOCK-OUT THAT ABLATES GERMLINE CELLS 审中-公开
    NANOS KNOCK-OUT消除了GERMLINE细胞

    公开(公告)号：WO2016011029A3

    公开(公告)日：2016-03-10

    申请号：PCT/US2015040379

    申请日：2015-07-14

    Applicant: UNIV WASHINGTON STATE ,  UNIV MARYLAND ,  UNIV EDINBURGH

    Inventor： OATLEY JOHN MICHAEL ,  WHITELAW CHRISTOPHER BRUCE ALEXANDER ,  LILLICO SIMON GEOFFREY ,  TELUGU BHANU PRAKASH

    IPC: C12N15/00 ,  A01K67/027

    CPC classification number: A01K67/0276 ,  A01K2217/075 ,  A01K2227/101 ,  A01K2227/108 ,  A01K2267/025 ,  C12N9/22 ,  C12N15/907 ,  C12Y301/00

    Abstract: The present invention provides livestock animals and methods to create recipient animals for spermatogonial stem cell transplantation through modulation of the NANOS gene. In one embodiment genome editing issued to create animals with insertions or deletions (indels) that inactivate or otherwise modulate NANOS gene activity so that resulting males lack functional germ cells yet retain functional somatic cells, and females are fertile. These males can then be transplanted with donor spermatogonial stem cells and used for breeding.

    Abstract translation: 本发明提供了家畜动物和通过调节NANOS基因来产生用于精原干细胞移植的受体动物的方法。 在一个实施方案中，发布基因组编辑以产生具有失活或以其他方式调节NANOS基因活性的插入或缺失（插入）的动物，从而使得到的雄性缺乏功能性生殖细胞，但保留功能性体细胞，并且雌性是可育的。 然后可以将这些雄性动物移植供体精原干细胞并用于育种。

    POLYPEPTIDE HAVING DNASE ACTIVITY FOR REDUCING STATIC ELECTRICITY
    9.
    发明申请
    POLYPEPTIDE HAVING DNASE ACTIVITY FOR REDUCING STATIC ELECTRICITY 审中-公开
    具有降低静电电位的DNASE活性的多肽

    公开(公告)号：WO2015181287A1

    公开(公告)日：2015-12-03

    申请号：PCT/EP2015/061829

    申请日：2015-05-28

    Applicant: NOVOZYMES A/S

    Inventor： ALLESEN-HOLM, Marie

    IPC: C11D3/386 ,  C12N9/22

    CPC classification number: C11D3/38636 ,  C11D17/049 ,  C12N9/22 ,  C12Y301/00

    Abstract: The present invention concerns the use of a polypeptide having deoxyribonuclease (DNase) activity for preventing, reducing or removing static electricity from an item; a composition comprising such polypeptide; a method for reducing or removing static electricity from an item; and a wipe for such use.

    Abstract translation: 本发明涉及具有脱氧核糖核酸酶（DNA酶）活性的多肽用于预防，减少或除去物品中的静电的用途; 包含该多肽的组合物; 一种减少或去除物品静电的方法; 和擦拭用于这种使用。

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