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公开(公告)号：WO2014015278A1
公开(公告)日：2014-01-23
申请号：PCT/US2013/051340
申请日：2013-07-19
申请人： CODEXIS, INC.
发明人： VROOM, Jonathan , BALATSKAYA, Svetlana , BARAK, Yoram , CLARK, Louis , CHOUDHARY, Trish , KARLSHOEJ, Kristian , VALLE, Fernando , CHAN, Kaman
CPC分类号： C12P7/64 , A61K8/342 , A61K2800/85 , C11D3/2013 , C12N9/0006 , C12N9/0008 , C12N9/001 , C12N9/1007 , C12N9/1029 , C12N9/16 , C12N9/88 , C12N9/93 , C12P7/04 , C12Y101/01 , C12Y101/011 , C12Y103/01009 , C12Y103/99 , C12Y201/01005 , C12Y203/01029 , C12Y203/01041 , C12Y203/01086 , C12Y203/0118 , C12Y301/02 , C12Y301/02001 , C12Y301/02027 , C12Y402/01059 , C12Y602/01 , C12Y602/01003
摘要： Recombinant microorganisms are provided which have been engineered to produce fatty alcohols. Also provided are recombinant microorganisms which comprise a heterologous polynucleotide encoding a fatty alcohol reductase enzyme and an introduced polynucleotide encoding a β-ketoacyl acyl carrier protein synthase.
摘要翻译： 提供了重组微生物，其已被工程化以生产脂肪醇。 还提供了包含编码脂肪醇还原酶的异源多核苷酸和编码β-酮酰酰基载体蛋白合酶的引入的多核苷酸的重组微生物。
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公开(公告)号：WO2005113744A1
公开(公告)日：2005-12-01
申请号：PCT/JP2005/009232
申请日：2005-05-20
IPC分类号： C12N1/15
CPC分类号： C12P7/46 , C08G63/16 , C12N9/16 , C12N15/77 , C12Y301/02001
摘要： コリネ型細菌をアセチルCoAハイドロラーゼ活性が低下するように改変することにより、コハク酸生産能を向上させ、該細菌を用いてコハク酸を製造する。
摘要翻译： 工程改造棒状细菌以降低其乙酰CoA水解酶活性，从而提高其生产琥珀酸的能力。 通过使用由此获得的细菌产生琥珀酸。
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公开(公告)号：WO2017085167A2
公开(公告)日：2017-05-26
申请号：PCT/EP2016/077956
申请日：2016-11-17
CPC分类号： C12P5/026 , C12N9/1029 , C12N9/1085 , C12N9/1217 , C12N9/13 , C12N9/16 , C12N9/88 , C12N9/93 , C12N15/52 , C12P7/40 , C12Y205/01 , C12Y207/02007 , C12Y207/02014 , C12Y207/02015 , C12Y208/03001 , C12Y208/03008 , C12Y301/02001 , C12Y301/02018 , C12Y301/0202 , C12Y401/01006 , C12Y401/01063 , C12Y604/01004 , C12Y604/01005
摘要： Described are methods for the production of isobutene comprising the enzymatic conversion of 3-methylcrotonic acid into isobutene wherein said 3-methylcrotonic acid is obtained by the enzymatic conversion of 3-methylcrotonyl-CoA into 3- methylcrotonic acid or wherein said 3-methylcrotonic acid is obtained by the enzymatic conversion of 3-hydroxyisovalerate (HIV) into 3-methylcrotonic acid. It is described that the enzymatic conversion of 3-methylcrotonic acid into isobutene can, e.g., be achieved by making use of a 3-methylcrotonic acid decarboxylase, preferably an FMN-dependent decarboxylase associated with an FMN prenyl transferase, an aconitate decarboxylase (EC 4.1.1.6), a methylcrotonyl-CoA carboxylase (EC 6.4.1.4), or a geranoyl-CoA carboxylase (EC 6.4.1.5).
摘要翻译： 描述了用于生产异丁烯的方法，其包括将3-甲基巴豆酸酶促转化为异丁烯，其中所述3-甲基巴豆酸通过将3-甲基巴豆基辅酶A酶促转化为3-甲基巴豆酸 或其中所述3-甲基巴豆酸是通过将3-羟基异戊酸（HIV）酶促转化为3-甲基巴豆酸而获得的。 据描述，3-甲基巴豆酸到异丁烯的酶促转化可以例如通过利用3-甲基巴豆酸脱羧酶，优选与FMN异戊烯转移酶，乌头酸脱羧酶（EC 4.1）相关的FMN依赖性脱羧酶 1.6），甲基巴豆酰辅酶A羧化酶（EC 6.4.1.4）或ge烯酰辅酶A羧化酶（EC 6.4.1.5）。
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4.发明申请PRODUCTION OF ODD CHAIN FATTY ACID DERIVATIVES IN RECOMBINANT MICROBIAL CELLS 审中-公开在重组微生物细胞中生产链状脂肪酸衍生物
公开(公告)号：WO2013039563A1
公开(公告)日：2013-03-21
申请号：PCT/US2012/028256
申请日：2012-03-08
CPC分类号： C12P7/6409 , C07C53/126 , C07C57/03 , C12N9/0006 , C12N9/1018 , C12N9/1029 , C12N9/1217 , C12N9/16 , C12N9/18 , C12N9/88 , C12N9/90 , C12Y101/01003 , C12Y101/01085 , C12Y201/03001 , C12Y203/01041 , C12Y207/02004 , C12Y301/02001 , C12Y401/01041 , C12Y401/03022 , C12Y402/01033 , C12Y402/03001 , C12Y403/01019 , C12Y504/99002
摘要： Recombinant microbial cells are provided which have been engineered to produce fatty acid derivatives having linear chains containing an odd number of carbon atoms by the fatty acid biosynthetic pathway. Also provided are methods of making odd chain fatty acid derivatives using the recombinant microbial cells, and compositions comprising odd chain fatty acid derivatives produced by such methods.
摘要翻译： 提供了重组微生物细胞，其已被工程化以通过脂肪酸生物合成途径产生具有含有奇数个碳原子的直链的脂肪酸衍生物。 还提供了使用重组微生物细胞制备奇数链脂肪酸衍生物的方法，以及包含通过这些方法产生的奇数链脂肪酸衍生物的组合物。
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