公开(公告)号：WO2012161852A3

公开(公告)日：2013-01-24

申请号：PCT/US2012027911

申请日：2012-03-06

Applicant: UNIV LOMA LINDA MED ,  SCHULTE REINHARD W ,  HURLEY R FORD

Inventor： SCHULTE REINHARD W ,  HURLEY R FORD

IPC: A61B6/03 ,  G12B13/00

CPC classification number: G01T7/005 ,  A61B6/032 ,  A61B6/035 ,  A61B6/4258 ,  A61B6/548 ,  A61B6/583 ,  A61B6/585 ,  G01N23/04 ,  G01N23/046 ,  G01N35/00693 ,  G01N2223/107 ,  G01T1/169 ,  G01T1/2985

Abstract: Disclosed are systems, devices and methodologies related to calibration of an ion based imaging apparatus such as a proton computed tomography scanner. In some implementations, energy degrader plates having known water-equivalent thickness (WET) values can be introduced to an ion beam to introduce different energy degradation settings. Energy detector responses to individual ions subject to such energy degradation settings can be obtained. Such responses can be normalized and correlated to water-equivalent path lengths (WEPL) of the ions based on the known WET values. Such calibration utilizing degrader plates can be performed relatively quickly and can yield accurate WEPL values that facilitate estimation of, for example, a CT image based on relative stopping power of an object.

Abstract translation: 公开了与基于离子的成像装置如质子计算机断层摄影扫描仪的校准相关的系统，装置和方法。 在一些实施方案中，具有已知水当量厚度（WET）值的能量降解板可被引入离子束以引入不同的能量降解设置。 可以获得能量检测器对受到这种能量劣化设置影响的个体离子的响应。 这些响应可以根据已知的WET值被归一化并且与离子的水当量路径长度（WEPL）相关。 利用降解板的这种校准可以相对快速地进行，并且可以产生准确的WEPL值，其有助于基于对象的相对停止功率来估计例如CT图像。

公开(公告)号：WO2012161852A2

公开(公告)日：2012-11-29

申请号：PCT/US2012/027911

申请日：2012-03-06

Applicant: LOMA LINDA UNIVERSITY MEDICAL CENTER ,  SCHULTE, Reinhard W. ,  HURLEY, R. Ford

Inventor： SCHULTE, Reinhard W. ,  HURLEY, R. Ford

IPC: G01N23/04

CPC classification number: G01T7/005 ,  A61B6/032 ,  A61B6/035 ,  A61B6/4258 ,  A61B6/548 ,  A61B6/583 ,  A61B6/585 ,  G01N23/04 ,  G01N23/046 ,  G01N35/00693 ,  G01N2223/107 ,  G01T1/169 ,  G01T1/2985

Abstract: Disclosed are systems, devices and methodologies related to calibration of an ion based imaging apparatus such as a proton computed tomography scanner. In some implementations, energy degrader plates having known water-equivalent thickness (WET) values can be introduced to an ion beam to introduce different energy degradation settings. Energy detector responses to individual ions subject to such energy degradation settings can be obtained. Such responses can be normalized and correlated to water-equivalent path lengths (WEPL) of the ions based on the known WET values. Such calibration utilizing degrader plates can be performed relatively quickly and can yield accurate WEPL values that facilitate estimation of, for example, a CT image based on relative stopping power of an object.

Abstract translation: 公开了与基于离子的成像装置如质子计算机断层摄影扫描仪的校准相关的系统，装置和方法。 在一些实施方案中，具有已知水当量厚度（WET）值的能量降解板可被引入离子束以引入不同的能量降解设置。 可以获得能量检测器对受到这种能量劣化设置影响的个体离子的响应。 这些响应可以根据已知的WET值被归一化并且与离子的水当量路径长度（WEPL）相关。 利用降解板的这种校准可以相对快速地进行，并且可以产生准确的WEPL值，其有助于基于对象的相对停止功率来估计例如CT图像。

公开(公告)号：WO2016016653A1

公开(公告)日：2016-02-04

申请号：PCT/GB2015/052208

申请日：2015-07-30

Applicant: UNIVERSITY OF LINCOLN

Inventor： ALLINSON, Nigel ,  EVANS, Phil ,  POLUDNIOWSKI, Gavin

IPC: A61B6/03 ,  A61N5/10 ,  G01N23/04 ,  A61N1/16

CPC classification number: G06T11/003 ,  A61B6/032 ,  A61B6/4258 ,  A61B6/5205 ,  A61N1/16 ,  A61N2005/1087 ,  G01N23/046 ,  G01N2223/107 ,  G01N2223/419 ,  G06T7/0012 ,  G06T11/00 ,  G06T2207/10081

Abstract: A method of reconstructing a3-dimensionalimage in a proton transmission computerised tomography (CT) apparatus is disclosed. The method comprises the creation of a reconstruction matrix. The matrix is created by directing a plurality of particles to traverse the object; and for each particle, measuring the trajectory and energy of each particle before and after it has traversed the object; for each particle, calculating the water-equivalent path length within the object; and for each particle, calculating the positions at which it entered and exited the object; and adding the water-equivalent path length, entry and exit positions to the reconstruction matrix. This procedure is repeated from a plurality of angular positions surrounding an object to be imaged. Then, a spatially varying 2- dimensional filter function is applied to the reconstruction matrix. Subsequently, a correction factor is applied to the filtered reconstruction matrix to at least partially correct for the finite extent of the matrix.

Abstract translation: 公开了一种在质子传播计算机断层摄影（CT）装置中重建三维图像的方法。 该方法包括创建重建矩阵。 矩阵是通过引导多个粒子来遍历对象而产生的; 并且对于每个粒子，测量每个粒子在其穿过物体之前和之后的轨迹和能量; 对于每个粒子，计算物体内的水当量路径长度; 并且对于每个粒子，计算它进入和退出物体的位置; 并将等效路径长度，入口和出口位置添加到重建矩阵中。 从围绕待成像对象的多个角位置重复该过程。 然后，将空间变化的二维滤波函数应用于重建矩阵。 随后，将校正因子应用于经滤波的重建矩阵，以至少部分地校正矩阵的有限范围。