公开(公告)号：WO2016034894A2

公开(公告)日：2016-03-10

申请号：PCT/GB2015/052564

申请日：2015-09-04

申请人： SINGH, Ishwar ,  TAYLOR, Edward ,  UNIVERSITY OF LINCOLN

发明人： SINGH, Ishwar ,  TAYLOR, Edward

IPC分类号： A61K38/14

CPC分类号： A61K47/64 ,  A61K31/7034 ,  A61K31/7056 ,  A61K38/14 ,  A61K38/164 ,  A61K47/59 ,  A61P31/04 ,  C07C271/20 ,  C07C277/08 ,  C07C279/12 ,  C07H13/00

摘要： The invention provides a combination of an antibacterial agent and a delivery agent, in which the delivery agent is bonded, or capable of binding, to the antibacterial agent, and in which the delivery agent is capable of binding to one or more structures on a bacterial cell membrane. The invention further provides the use of such combinations in treating or preventing bacterial infections.

摘要翻译： 本发明提供了抗菌剂和递送剂的组合，其中递送剂与抗菌剂结合或能够结合，并且其中递送剂能够结合细菌上的一种或多种结构 细胞膜。 本发明还提供了这样的组合在治疗或预防细菌感染中的用途。

公开(公告)号：WO2016016653A1

公开(公告)日：2016-02-04

申请号：PCT/GB2015/052208

申请日：2015-07-30

申请人： UNIVERSITY OF LINCOLN

发明人： ALLINSON, Nigel ,  EVANS, Phil ,  POLUDNIOWSKI, Gavin

IPC分类号： A61B6/03 ,  A61N5/10 ,  G01N23/04 ,  A61N1/16

CPC分类号： G06T11/003 ,  A61B6/032 ,  A61B6/4258 ,  A61B6/5205 ,  A61N1/16 ,  A61N2005/1087 ,  G01N23/046 ,  G01N2223/107 ,  G01N2223/419 ,  G06T7/0012 ,  G06T11/00 ,  G06T2207/10081

摘要： A method of reconstructing a3-dimensionalimage in a proton transmission computerised tomography (CT) apparatus is disclosed. The method comprises the creation of a reconstruction matrix. The matrix is created by directing a plurality of particles to traverse the object; and for each particle, measuring the trajectory and energy of each particle before and after it has traversed the object; for each particle, calculating the water-equivalent path length within the object; and for each particle, calculating the positions at which it entered and exited the object; and adding the water-equivalent path length, entry and exit positions to the reconstruction matrix. This procedure is repeated from a plurality of angular positions surrounding an object to be imaged. Then, a spatially varying 2- dimensional filter function is applied to the reconstruction matrix. Subsequently, a correction factor is applied to the filtered reconstruction matrix to at least partially correct for the finite extent of the matrix.

摘要翻译： 公开了一种在质子传播计算机断层摄影（CT）装置中重建三维图像的方法。 该方法包括创建重建矩阵。 矩阵是通过引导多个粒子来遍历对象而产生的; 并且对于每个粒子，测量每个粒子在其穿过物体之前和之后的轨迹和能量; 对于每个粒子，计算物体内的水当量路径长度; 并且对于每个粒子，计算它进入和退出物体的位置; 并将等效路径长度，入口和出口位置添加到重建矩阵中。 从围绕待成像对象的多个角位置重复该过程。 然后，将空间变化的二维滤波函数应用于重建矩阵。 随后，将校正因子应用于经滤波的重建矩阵，以至少部分地校正矩阵的有限范围。

公开(公告)号：WO2013164651A2

公开(公告)日：2013-11-07

申请号：PCT/GB2013/051176

申请日：2013-05-07

申请人： THE UNIVERSITY OF LINCOLN

发明人： ALLINSON, Nigel ,  ANAXAGORAS, Thalis

IPC分类号： G01N21/47 ,  G01N21/64

CPC分类号： G01N21/47 ,  G01N21/64 ,  G01N21/6454 ,  G01N33/4833 ,  G01N2201/062

摘要： In one aspect of the invention there is provided apparatus comprising :a substrate, the substrate having: a source for generating an inspection medium for illuminating a subject object; a detector for detecting a response by a subject object to illumination by the inspection medium; and at least one conduit formed through at least a portion of the substrate for transmission of inspection medium there through in a path from the source to the subject object or a path from the subject object to the detector, the conduit being arranged wherein the source and detector are not in direct line of sight of one another.

摘要翻译： 在本发明的一个方面，提供了一种设备，包括：基板，所述基板具有：用于产生用于照射被摄体的检查介质的源; 检测器，用于检测被检体对由检查介质照射的响应; 以及至少一个导管，其形成为穿过所述基板的至少一部分，用于在从所述源到所述被检物体的路径或从所述物体到所述检测器的路径中透过所述检查介质，所述导管布置成其中所述源和 检测器不是彼此的直接视线。

公开(公告)号：WO2007107792A1

公开(公告)日：2007-09-27

申请号：PCT/GB2007/050138

申请日：2007-03-21

申请人： THE UNIVERSITY OF LINCOLN ,  WHITE, Peter, Cyril ,  HJORTKJÆR, Jakob, Howie

发明人： WHITE, Peter, Cyril ,  HJORTKJÆR, Jakob, Howie

IPC分类号： B01J13/00 ,  C22B11/00 ,  B22F1/00 ,  B22F9/24

CPC分类号： B01J13/0043 ,  B22F1/0022 ,  B22F9/24 ,  B82Y15/00 ,  B82Y30/00 ,  C22B11/04

摘要： A method is described for producing highly stable silver colloidal solu- tions by reducing silver nitrate with lithium citrate. In the method, the main steps consist of: (a) heating a first quantity of water to a first predetermined temperature; (b) adding a second quantity of silver nitrate to the water; (c) heat- ing the mixture to a second predetermined temperature; (d) adding a third quan- tity of an aqueous lithium citrate solution to the mixture; (e) maintaining the mix- ture at the second predetermined temperature for a predetermined time; and (f) cooling the mixture. The mixing process is accompanied by constant stirring. The colloid exhibits high light-scattering properties and intense SERS or SERRS spectra with low background fluorescence levels and a long shelf life, making it particularly suitable for Raman spectroscopy.

摘要翻译： 描述了通过用柠檬酸锂还原硝酸银来生产高度稳定的银胶体溶液的方法。 在该方法中，主要步骤包括：（a）将第一量的水加热至第一预定温度; （b）向水中加入第二量的硝酸银; （c）将混合物加热至第二预定温度; （d）向混合物中加入第三量的柠檬酸锂水溶液; （e）将混合物保持在第二预定温度一段预定时间; 和（f）冷却混合物。 混合过程伴随着持续搅拌。 胶体表现出高的光散射性能和强烈的SERS或SERRS光谱，具有低背景荧光水平和长保质期，使其特别适用于拉曼光谱。

公开(公告)号：WO2016193714A1

公开(公告)日：2016-12-08

申请号：PCT/GB2016/051597

申请日：2016-06-01

申请人： THE UNIVERSITY OF LINCOLN

发明人： CHRISTIE, Michael ,  MCLAUGHLIN, Kerry ,  JOHNSON, Carolyn ,  RAVISHANKAR, Aarthi

IPC分类号： G01N33/68

CPC分类号： G01N33/6893 ,  A61K38/1709 ,  A61P3/10 ,  C07K14/47 ,  G01N2800/042

摘要： A method for the diagnosis of Type 1 diabetes, or a predisposition towards Type 1 diabetes, or to monitor the efficacy of a therapy to prevent or treat Type 1 diabetes, said method comprising contacting a sample from a subject with a reagent selected from Tetraspanin-7 or a fragment, or a modified form thereof, and detecting an interaction indicative of the presence of an autoimmune response to Tetraspanin-7. Tetraspanin-7 is now understood to be the protein recognised by Glima 38 specific antibodies. Reagents and kits for use in the method and therapies associated with these form further aspects of the invention.

摘要翻译： 用于诊断1型糖尿病或倾向于1型糖尿病的方法或监测治疗预防或治疗1型糖尿病的功效的方法，所述方法包括使来自受试者的样品与选自Tetraspanin- 7或片段或其修饰形式，并检测指示存在对四肽蛋白-7的自身免疫应答的相互作用。 四肽蛋白-7现在被理解为由Glima 38特异性抗体识别的蛋白质。 用于与这些相关联的方法和疗法的试剂和试剂盒形成本发明的另外的方面。

公开(公告)号：WO2014188158A1

公开(公告)日：2014-11-27

申请号：PCT/GB2014/051390

申请日：2014-05-06

申请人： THE UNIVERSITY OF LINCOLN

发明人： GONZALEZ-RODRIGUEZ, Jose

IPC分类号： B01J20/26 ,  C22B3/24 ,  C22B7/00 ,  C08F2/44 ,  B01J39/20 ,  C02F1/56 ,  C08J5/20 ,  C08F6/02 ,  C08J9/26 ,  C08F6/28 ,  C22B3/20 ,  B01J41/14

CPC分类号： C22B7/007 ,  B01J20/268 ,  C02F1/285 ,  C02F2101/20 ,  C08F2/44 ,  C08F6/02 ,  C08F6/28 ,  C08J9/286 ,  C08J2201/0502 ,  C08J2205/024 ,  C08J2205/028 ,  C08J2339/08 ,  C08J2347/00 ,  C22B3/24 ,  C22B61/00 ,  Y02P10/234 ,  C08F226/06 ,  C08F2222/1013

摘要： A process of forming a porous polymer template material for use in selectively recovering a metal from a solution of the metal ions comprises polymerising a monomer admixed with a compound of the metal to be recovered, and then treating the polymer to remove the metal compound therefrom. A method of selectively recovering a metal from a solution containing the metal ions comprises contacting a polymer template material formed by a process according to any preceding claim with the solution containing the metal ions, and recovering the metal from the polymer. The invention also proves a polymeric material adapted to capture from a solution containing ions of plural metals a specific one of the metals.

摘要翻译： 形成用于从金属离子溶液中选择性回收金属的多孔聚合物模板材料的方法包括聚合与待回收金属的化合物混合的单体，然后处理聚合物以从其中除去金属化合物。 从包含金属离子的溶液中选择性地回收金属的方法包括使由根据前述权利要求中任一项所述的方法形成的聚合物模板材料与含有金属离子的溶液接触，并从聚合物中回收金属。 本发明还证明了一种适于从含有多种金属离子的溶液中捕获特定金属的聚合材料。

公开(公告)号：WO2012073016A1

公开(公告)日：2012-06-07

申请号：PCT/GB2011/052355

申请日：2011-11-29

申请人： UNIVERSITY OF LINCOLN ,  YUE, Shigang ,  HUNTER, Andrew ,  GUO, Kun

发明人： YUE, Shigang ,  HUNTER, Andrew ,  GUO, Kun

IPC分类号： A61B3/113 ,  A61B5/024 ,  A61B5/01 ,  A61B5/16

CPC分类号： A61B5/165 ,  A61B3/113 ,  A61B5/015 ,  A61B5/024 ,  A61B5/167

摘要： A response detection system comprising: stimulation means for delivering a visual and/or an auditory stimulus to a target subject; a remote non-contact sensor configured to monitor a physiological indicator in the subject, the physiological indicator including at least one of heart rate and temperature; and processing means configured to detect a change in the monitored physiological indicator in response to the stimulus and to determine if the change exceeds a predetermined threshold.

摘要翻译： 一种响应检测系统，包括：刺激装置，用于将目标对象的视觉和/或听觉刺激传递; 远程非接触传感器，被配置为监测所述对象中的生理指示器，所述生理指示器包括心率和温度中的至少一个; 以及处理装置，被配置为响应于所述刺激来检测所监视的生理指示符的变化，并且确定所述改变是否超过预定阈值。

公开(公告)号：WO2023002166A1

公开(公告)日：2023-01-26

申请号：PCT/GB2022/051850

申请日：2022-07-18

申请人： UNIVERSITY OF LINCOLN

发明人： AL-DIRI, Bashir Ibrahim ,  ELGENEIDY, Khaled Ahmed ,  BURGON, Jason Grant ,  PEARSON, Simon

IPC分类号： A01G18/70 ,  A01D46/24

摘要： Broadly speaking, embodiments of the present techniques provide a method for harvesting mushrooms which grow in clusters, by determining a picking schedule that maximises the yield while minimising damage to the mushroom or surrounding mushrooms to thereby increase shelf-life.

公开(公告)号：WO2022090742A1

公开(公告)日：2022-05-05

申请号：PCT/GB2021/052826

申请日：2021-11-01

申请人： UNIVERSITY OF LINCOLN

发明人： ALLINSON, Nigel ,  ESPOSITO, Michela

IPC分类号： A61N5/10 ,  G01T1/20

摘要： An energy determining apparatus (100) for determining the individual energy of one or more particles of hadron radiation (40) has a main axis (101) for aligning with a general direction of incident particles (40). The apparatus comprises a two-dimensional array of scintillator elements (41) configured to emit a quantity of light in response to energy of one or more incident particles of hadron radiation (40) passing through, or along, that scintillator element (41). Each of the scintillator elements (41) is an elongate element with a longitudinal axis extending parallel to the main axis (101). An array of detectors (44) convert the light from the scintillator elements (41) into electrical signals. A processor (115) is configured to determine a total quantity of light corresponding to energy of a single particle (40) based on outputs of the array of detectors (44).

公开(公告)号：WO2015189603A1

公开(公告)日：2015-12-17

申请号：PCT/GB2015/051692

申请日：2015-06-09

申请人： UNIVERSITY OF LINCOLN

发明人： ALLINSON, Nigel ,  RILEY, Grainne ,  WALTHAM, Chris ,  ESPOSITO, Michela ,  PRICE, Tony ,  ALLPORT, Phil ,  TAYLOR, Jon ,  CASSE, Gianluigi ,  EVANS, Phil ,  POLUDNIOWSKI, Gavin ,  GREEN, Stuart ,  MANOLOPOULOS, Spyros ,  NIETO-CAMERO, Jaime ,  VERHOEVEN, Marcus

IPC分类号： A61N5/10

CPC分类号： A61N5/1071 ,  A61B6/032 ,  A61B6/4064 ,  A61B6/4241 ,  A61B6/4258 ,  A61B6/4266 ,  A61N5/1077 ,  A61N2005/1054 ,  A61N2005/1085 ,  A61N2005/1087 ,  G01T1/02 ,  G01T1/2928 ,  G01T1/2985

摘要： Some embodiments of the present invention provide apparatus having a particle beamline for passage of charged particles of radiation therealong, comprising: a first beam tracker structure comprising at least one position sensitive detector (PSD) for determining a location with respect to a cross-sectional area of the beam line at which particles pass through the PSD; energy discrimination apparatus for determining an energy of particles that have passed through the first beam tracker structure; and support means for supporting a subject in a path of a particle along the beamline between the first beam tracker structure and the energy discrimination apparatus, the apparatus being configured to be operated in a selected one of a first mode and a second mode, the apparatus being configured, in the first mode of operation, to control an energy of the beam of charged particles passing through the first beam tracker structure such that a Bragg peak of charged particle absorption is located within the subject, and in the second mode of operation, to control an energy of the beam of charged particles passing through the first beam tracker structure such that a Bragg peak of charged particle absorption is located within the energy discrimination apparatus.

摘要翻译： 本发明的一些实施例提供具有粒子束线的装置，该粒子束线用于沿其上的带电粒子的通过，包括：第一光束跟踪器结构，包括至少一个位置敏感检测器（PSD），用于确定相对于横截面积的位置 的粒子通过PSD的束线; 用于确定通过第一光束跟踪器结构的颗粒的能量的能量鉴别装置; 以及支撑装置，用于支撑沿着第一光束跟踪器结构和能量判别装置之间的束线的粒子路径中的对象，该装置被配置为以第一模式和第二模式中的选定的一个操作，该装置 在第一操作模式中，控制通过第一光束跟踪器结构的带电粒子束的能量，使得带电粒子吸收的布拉格峰位于被摄体内，而在第二操作模式中， 以控制通过第一光束跟踪器结构的带电粒子束的能量，使得带电粒子吸收的布拉格峰位于能量鉴别装置内。