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    TPST-ASSAY FOR DIAGNOSIS OF AUTISM AND RELATED DISORDERS
    1.
    发明申请
    TPST-ASSAY FOR DIAGNOSIS OF AUTISM AND RELATED DISORDERS 审中-公开
    用于诊断感染和相关疾病的TPST测定

    公开(公告)号：WO01077681A1

    公开(公告)日：2001-10-18

    申请号：PCT/GB2001/001569

    申请日：2001-04-05

    IPC分类号： A61P1/18 ,  A61P3/04 ,  A61P5/48 ,  A61P25/14 ,  A61P25/18 ,  C12Q1/68 ,  G01N33/573 ,  G01N33/68 ,  C12Q1/48

    CPC分类号： C12Q1/6883 ,  C12Q2600/158 ,  G01N33/573 ,  G01N33/6896 ,  G01N2333/91194

    摘要： The present invention relates to a method for diagnosing or detecting a predisposition to autism and related diseases comprising assaying a bodily sample in vitro directly or indirectly for a reduced tyrosyl protein sulphotransferase (TPST) level as compared to a reference sample, and a method of treatment for the same diseases by administering to a patient suffering therefrom a therapeutic amount of an enhancer of TPST.

    摘要翻译： 本发明涉及用于诊断或检测自闭症和相关疾病倾向的方法，其包括直接或间接测定体外样品，以减少酪氨酸蛋白质转移酶（TPST）水平，与参考文献相比较 样品，以及通过给患有治疗量的TPST增强剂的患者施用相同疾病的方法。

    LARGE, HS6ST2 OR ST8SIA1 ACTIVATORS FOR PREVENTING AND/OR ATTENUATING SKIN AGEING AND/OR HYDRATING SKIN
    2.
    发明申请
    LARGE, HS6ST2 OR ST8SIA1 ACTIVATORS FOR PREVENTING AND/OR ATTENUATING SKIN AGEING AND/OR HYDRATING SKIN 审中-公开
    大量的HS6ST2或ST8SIA1激活剂，用于预防和/或减轻皮肤老化和/或水解皮肤

    公开(公告)号：WO2012156420A1

    公开(公告)日：2012-11-22

    申请号：PCT/EP2012/059064

    申请日：2012-05-15

    申请人： CHANEL PARFUMS BEAUTE ,  ELENA, Fedorova ,  LASSERRE, Christelle

    发明人： ELENA, Fedorova ,  LASSERRE, Christelle

    IPC分类号： G01N33/50 ,  G01N33/68

    CPC分类号： C12Q1/6876 ,  A61K8/062 ,  A61K8/345 ,  A61K8/347 ,  A61K8/735 ,  A61K8/8152 ,  A61K8/92 ,  A61K2800/78 ,  A61Q19/004 ,  A61Q19/007 ,  A61Q19/08 ,  C12Q2600/148 ,  C12Q2600/158 ,  C12Y208/02 ,  G01N33/5023 ,  G01N33/5044 ,  G01N33/6881 ,  G01N2333/91194 ,  G01N2800/20

    摘要： The invention relates to the identification and the use of compounds which activate the expression of at least one gene selected from LARGE, HS6ST2 and ST8SIA1, for preventing and/or attenuating ageing, and/or for hydrating skin. The invention thus relates to an in vitro method for screening for candidate compounds for preventing and/or attenuating ageing of the skin, and/or for hydrating the skin, comprising the following steps: a. bringing at least one test compound in contact with a sample of keratinocytes; b. measuring the expression of at least one gene selected from LARGE, HS6ST2 and ST8SIA1, in said keratinocytes; c. selecting the compounds for which an activation of at least 1.4 fold of the expression of at least one of said genes is measured in the keratinocytes treated in a. compared with the untreated keratinocytes.

    摘要翻译： 本发明涉及确定和使用激活表达至少一种选自LARGE，HS6ST2和ST8SIA1的基因的化合物，以预防和/或减弱老化和/或保湿皮肤。 因此，本发明涉及用于筛选候选化合物以预防和/或减弱皮肤老化和/或使皮肤保湿的体外方法，包括以下步骤：a。 使至少一种测试化合物与角化细胞样品接触; 湾 测量所述角质形成细胞中至少一种选自LARGE，HS6ST2和ST8SIA1的基因的表达; C。 选择在a处理的角质形成细胞中测量至少一种所述基因表达的至少1.4倍的活化的化合物。 与未处理的角质形成细胞相比。

    HOMOCYSTEINE ASSAY
    4.
    发明申请
    HOMOCYSTEINE ASSAY 审中-公开
    同位素测定

    公开(公告)号：WO01077670A3

    公开(公告)日：2002-05-16

    申请号：PCT/GB2001/001615

    申请日：2001-04-10

    IPC分类号： G01N33/68 ,  C12Q1/48 ,  C12Q1/527 ,  G01N21/78

    CPC分类号： C12Q1/48 ,  G01N2333/91194

    摘要： The present invention provides an improved method of assessing/quantifying the amount of homocysteine in a body fluid sample via an enzymatic assay which comprises reducing background signal by treatment with one of the following: a reducing agent, a pyruvate deactivating agent, heat treatment, or by lyophilising or immobilzing the homocysteine converting enzyme.

    摘要翻译： 本发明提供了一种通过酶测定来评估/定量体液样品中同型半胱氨酸量的改进方法，其包括通过以下之一处理降低背景信号：还原剂，丙酮酸钝化剂，热处理或 通过冻干或固定同型半胱氨酸转化酶。

    HIGH SPECIFICITY HOMOCYSTEINE ASSAYS FOR BIOLOGICAL SAMPLES
    10.
    发明申请
    HIGH SPECIFICITY HOMOCYSTEINE ASSAYS FOR BIOLOGICAL SAMPLES 审中-公开
    用于生物样品的高特异性半胱氨酸测定

    公开(公告)号：WO99005311A1

    公开(公告)日：1999-02-04

    申请号：PCT/US1998/015430

    申请日：1998-07-24

    IPC分类号： C12N15/09 ,  C12N1/21 ,  C12N9/02 ,  C12N9/10 ,  C12N9/14 ,  C12Q1/25 ,  C12Q1/34 ,  C12Q1/527 ,  C12Q1/68 ,  C12R1/19 ,  G01N33/68

    CPC分类号： C12N9/0051 ,  C07K2319/00 ,  C12N9/13 ,  C12Q1/527 ,  G01N33/6815 ,  G01N2333/90212 ,  G01N2333/91194

    摘要： The novel methods of the invention involve use of particular homocysteinase enzymes that permit the determination of homocysteine concentrations in biological samples without interference from the concentrations of cysteine and/or of methionine that are routinely present in such samples. There is also provided a diagnostic kit for use in determining the amount of homocysteine in a biological sample comprising (a) a homocysteinase having the aformentioned characteristics, and (b) at least one reagent capable of being used to determine the amount of product formed in the homocysteinase reaction. In a further aspect, the homocysteinase is provided as a chimeric molecule that comprises amino acid subsequences derived from, or patterned on, more than one homocysteinase, and which is typically produced from a chimeric polynucleotide that encodes therefor. Additional enhancements in homocysteine assay methodology include use of the enzyme gamma -glutamylcysteine synthetase to further limit any interference from cysteine present in the biological samples.

    摘要翻译： 本发明的新方法涉及使用特异性同型半胱氨酸酶，其允许在生物样品中测定同型半胱氨酸浓度，而不受这些样品中常规存在的半胱氨酸和/或甲硫氨酸的浓度的干扰。 还提供了用于确定生物样品中同型半胱氨酸量的诊断试剂盒，其包含（a）具有上述特征的同型半胱氨酸酶，和（b）至少一种可用于测定形成的产物量的试剂 同型半胱氨酸酶反应。 在另一方面，提供同型半胱氨酸酶作为嵌合分子，其包含衍生自或多于一种同型半胱氨酸酶的图案化的氨基酸亚序列，并且其通常由其编码的嵌合多核苷酸产生。 同型半胱氨酸测定方法的其它改进包括使用γ-谷氨酰半胱氨酸合成酶来进一步限制存在于生物样品中的半胱氨酸的任何干扰。