公开(公告)号：WO2017035189A1

公开(公告)日：2017-03-02

申请号：PCT/US2016/048315

申请日：2016-08-24

Applicant: MASSACHUSETTS INSTITUTE OF TECHNOLOGY

Inventor： ILIC, Ognjen ,  KAMINER, Ido E. ,  SOLJACIC, Marin ,  LAHINI, Yoav

IPC: G01N33/00 ,  G02F1/00 ,  G02F1/1337 ,  B81B1/00 ,  B81B3/00 ,  B82B1/00 ,  B82B3/00

CPC classification number: H05H3/04 ,  C01B21/076 ,  G02B21/32

Abstract: A technique to guide a micro- or nano-scale particle uses the wavelengths of light beams to control the direction of motion of the particle. In this technique, an optical asymmetry is introduced into the particle to form a composite particle. The composite particle includes two faces that preferentially absorb light of different wavelengths, independent of the particle orientation. The difference in absorption spectra of the two faces creates a bidirectional and local thermal gradient that is externally switchable by changing the wavelength of the incident light beams. This thermal gradient induces a thermophoretic drift that moves the composite particle. A two-faced nanoparticle can be guided using the optically induced thermophoretic drift as the propulsion mechanism.

Abstract translation: 引导微尺度或纳米级粒子的技术使用光束的波长来控制粒子的运动方向。 在该技术中，将光学不对称性引入到颗粒中以形成复合颗粒。 复合颗粒包括两个不同于颗粒取向的吸收不同波长的光的表面。 两个面的吸收光谱差异产生双向和局部热梯度，通过改变入射光束的波长可从外部切换。 该热梯度引起移动复合颗粒的热泳漂移。 可以使用光学诱导的热泳漂移作为推进机制来引导双面纳米颗粒。

公开(公告)号：WO2010055541A1

公开(公告)日：2010-05-20

申请号：PCT/IT2009/000515

申请日：2009-11-13

Applicant: ACHILLE ZANZUCCHI EDITORE DI ACHILLE ZANZUCCHI ,  ZANZUCCHI Achille

Inventor： ZANZUCCHI Achille

IPC: H05H3/04 ,  B03C1/32 ,  F03H99/00

CPC classification number: H05H3/04 ,  B03C1/32

Abstract: An electromagnetic device for accelerating electrically neutral molecules of a substance is characterized by the fact of comprising: a Treating Tube (14) in non-conducting material, into which the substance to treat is introduced; static electromagnetic circuits that surround the above Treating Tube exerting on the substance to treat electromagnetic actions which push it axially, with utilization of the dipolar electric moment of the molecules. The treating method of the molecules accelerates these molecules utilizing their weak dipolar electric moment, subjecting them to a combination of a magnetic field and an electric one or, in alternative, of a magnetic field and one at Hertz waves, alternating and isofrequential, utilizing the Lorentz force of electrology.

Abstract translation: 一种用于加速物质的电中性分子的电磁装置的特征在于包括：在导电材料中引入待处理物质的处理管（14）; 围绕上述处理管的静电电磁线圈施加在物质上，以利用分子的偶极电力矩来轴向推动它的电磁作用。 分子的处理方法利用它们的弱偶极电力矩来加速这些分子，使它们与磁场和电场相结合，或者替代地，以一个磁场和一个以赫兹波的方式交替和有效， 洛伦兹电磁力。

公开(公告)号：WO2010055540A1

公开(公告)日：2010-05-20

申请号：PCT/IT2009/000514

申请日：2009-11-13

Applicant: ACHILLE ZANZUCCHI EDITORE DI ACHILLE ZANZUCCHI ,  ZANZUCCHI, Achille

Inventor： ZANZUCCHI, Achille

IPC: H05H3/04 ,  B03C1/32 ,  F03H99/00

CPC classification number: H05H3/04 ,  B03C1/32

Abstract: A static electromagnetic device for accelerating electrically neutral molecules utilizing their dipolar electric moment is characterized by the fact of comprising comprise: a treating tube in non-conducting material, internally empty or filled with inert material, into which a (fluid or solid) substance to treat is introduced; static electromagnetic circuits that surround the above treating tube exerting on the substance to treat electromagnetic actions that push it axially.

Abstract translation: 用于利用其偶极电力矩来加速电中性分子的静电电磁装置的特征在于包括：在非导电材料中处理管，内部为空的或填充有惰性材料，其中（流体或固体）物质 治疗被介绍; 围绕上述处理管的静电电磁线路施加在物质上以处理推动其轴向的电磁作用。

公开(公告)号：WO2009018183A2

公开(公告)日：2009-02-05

申请号：PCT/US2008071284

申请日：2008-07-27

Applicant: HARVARD COLLEGE ,  CROZIER KEN

Inventor： CROZIER KEN

IPC: H01S3/04

CPC classification number: H05H3/04

Abstract: A new optical tweezer technology, based on optical antennas. Optical antennas are metallic nanostructures that, when illuminated at their resonant wavelength, generate enhanced optical fields with subwavelength spatial extent. The trapping of single virus particles using optical antennas with milliwatt laser powers, in volumes with dimensions of tens of nanometers. This represents a reduction in the necessary laser power by -2-3 orders of magnitude. The spatial resolution provided by the antennas will enable nanostructures to be manipulated in a highly precise manner. Optical antennas remove the need for costly objective lenses used in conventional tweezers to provide the gradient forces necessary for stable trapping. Traps can be produced on a chip by high-resolution lithography, enabling microsystems with thousands of traps.

Abstract translation: 基于光学天线的新型光学镊子技术。 光学天线是金属纳米结构，当以其共振波长照射时，产生具有亚波长空间范围的增强光场。 使用毫瓦级激光功率的光学天线捕获单个病毒颗粒，尺寸为几十纳米。 这代表必要的激光功率减少-2-3个数量级。 由天线提供的空间分辨率将使纳米结构能够以高度精确的方式被操纵。 光学天线不需要使用传统镊子中昂贵的物镜来提供稳定陷波所需的梯度力。 陷阱可以通过高分辨率光刻技术在芯片上生成，从而实现具有数千个陷阱的微系统。

公开(公告)号：WO2004012133A9

公开(公告)日：2004-04-29

申请号：PCT/US0323822

申请日：2003-07-31

Applicant: ARRYX INC ,  GRUBER LEWIS ,  BRADLEY KENNETH ,  LOPES WARD ,  LANCELOT ROBERT W ,  PLEWA JOSEPH S ,  GRIER DAVID

Inventor： GRUBER LEWIS ,  BRADLEY KENNETH ,  LOPES WARD ,  LANCELOT ROBERT W ,  PLEWA JOSEPH S ,  GRIER DAVID

IPC: B01L3/00 ,  G01N15/14 ,  G01N30/00 ,  G01N30/02 ,  G21K1/00 ,  G06K

CPC classification number: G01N15/1459 ,  B01L3/5027 ,  G01N2015/149 ,  G02B21/32 ,  G03H1/08 ,  G03H1/2294 ,  G03H2001/0077 ,  G03H2001/085 ,  G03H2225/32 ,  H05H3/04

Abstract: The present invention employs a beam steering apparatus to isolate valuable cells from others cells, tissues, and contaminants. In one embodiment, the system balances optical trapping agains flow to parallelize cell sorting under the flexible control of computer program-directed traps which differentially manipulate cells based on their composition or labels to direct separation.

Abstract translation: 本发明采用光束转向装置来从其它细胞，组织和污染物中分离有价值的细胞。 在一个实施例中，系统平衡光学捕获流程，以在计算机程序导向的陷阱的灵活控制下平行化细胞分选，其基于它们的组成或标签差异地操纵细胞以引导分离。

公开(公告)号：WO0244689A8

公开(公告)日：2002-11-14

申请号：PCT/US0145058

申请日：2001-11-28

Applicant: UNIV CALIFORNIA ,  WANG MARK ,  ATA ERHAN ,  ESENER SADIK

Inventor： WANG MARK ,  ATA ERHAN ,  ESENER SADIK

IPC: G21K1/00 ,  H05H3/04 ,  G01N

CPC classification number: H05H3/04

Abstract: Small particles 1, for example 5 mu m diameter microspheres or cells, within, and moving with, a fluid 2, normally water, that is flowing within microfluidic channels 3 within a radiation-transparent substrate 4, typically molded PDMS clear plastic, are selectively manipulated, normally by being pushed with optical pressures forces, with a laser light switching beam 5, preferably as arises from VCSELs operating in Laguerre-Gaussian mode, at branching junctions, such as an "X", in the microfluidic channels 3 so as to enter into selected downstream branches OUTPUT 1, OUPUT 2, thereby realizing switching and sorting of particles 1, including in parallel. Transport of the small particles 1 thus transpires by microfluidics while manipulation in the manner of optical tweezers arises either from pushing due to optical scattering force, or from pulling due to an attractive optical gradient force. Whether pushed or pulled, the particles within the flowing fluid may be optically sensed, and highly-parallel. Low-cost, cell- and particle-analysis devices efficiently realized, including as integrated on bio-chips.

Abstract translation: 在通常模制的PDMS透明塑料的辐射透明基底4内流动的微流体通道3内流动的流体2（通常为水）内的微粒1，例如5μm直径的微球或细胞，是选择性的 通常通过用光学压力推动的激光切换光束5，优选地如在来自微型流体通道3中的分支结点（例如“X”）由在Laguerre-Gaussian模式下操作的VCSEL产生的，以便 进入选择的下游分支OUTPUT 1，OUPUT 2，从而实现并行包括颗粒1的切换和分类。 因此，通过微流体传输小颗粒1，同时以光学镊子的方式进行操作会由于光学散射力的推动或由于有吸引力的光学梯度力的拉动而产生。 无论是推动还是被拉动，流动流体中的颗粒可以被光学感测并且高度平行。 低成本，细胞和粒子分析装置有效实现，包括集成在生物芯片上。

公开(公告)号：WO99039223A1

公开(公告)日：1999-08-05

申请号：PCT/US1999/002369

申请日：1999-02-03

IPC: G01N1/02 ,  B01J19/00 ,  B60R21/01 ,  B60R21/015 ,  B82B3/00 ,  G02B5/18 ,  G02B5/32 ,  G02B21/32 ,  G02B27/10 ,  G21K1/00 ,  H05H3/04 ,  G02B27/44

CPC classification number: H05H3/04 ,  G02B5/18 ,  G02B21/32 ,  G02B27/1086 ,  G02B27/1093 ,  Y10S359/90

Abstract: An apparatus and method for manipulating small dielectric particles. The apparatus and method involves use of a diffractive optical element (40) which receives a laser beam and forms a plurality of light beams. These light beams are operated on by a telescope lens system (34) and then an objective lens element (20) to create an array of optical traps (50) for manipulating small dielectric particles.

Abstract translation: 一种用于操纵小电介质颗粒的装置和方法。 该装置和方法包括使用接收激光束并形成多个光束的衍射光学元件（40）。 这些光束由望远镜透镜系统（34）和物镜元件（20）操作，以产生用于操纵小电介质颗粒的光学阱（50）阵列。

公开(公告)号：WO1997012376A1

公开(公告)日：1997-04-03

申请号：PCT/BY1996000009

申请日：1996-09-18

Applicant: SOROKO, Alexandr Valerievich

IPC: G21K01/00

CPC classification number: H05H3/04 ,  G03H1/00 ,  G21K1/00

Abstract: A method of controlling the amplitude-phase characteristics of an atomic wave involves allowing a beam of atoms to pass through a region of spatially non-homogeneous electromagnetic radiation produced by the superposition of an electromagnetic wave from any object and a planar reference electromagnetic wave. The atom beam is directed along or against the reference electromagnetic wave and, once an atomic wave has been obtained which imitates the electromagnetic wave from the object, an image of the object is recreated in the atom beams, compensation for the gravity acting on the atoms being applied in the region of distribution of the atoms.

Abstract translation: 控制原子波的振幅相位特性的方法涉及允许原子束通过由任何物体和平面参考电磁波叠加的电磁波产生的空间非均匀电磁辐射的区域。 原子束沿着或抵靠参考电磁波引导，并且一旦获得了模仿来自物体的电磁波的原子波，则在原子束中再现对象的图像，补偿作用在原子上的重力 应用于原子分布区域。

公开(公告)号：WO1996041154A1

公开(公告)日：1996-12-19

申请号：PCT/US1996010007

申请日：1996-06-07

Applicant: NATIONAL INSTITUTE OF STANDARDS AND TECHNOLOGY ,  WEETALL, Howard, Hayyam ,  HELMERSON, Kristian, Peter ,  KISHORE, Roni, Bakhru

Inventor： NATIONAL INSTITUTE OF STANDARDS AND TECHNOLOGY

IPC: G01N21/39

CPC classification number: H05H3/04 ,  G01N33/54313 ,  G01N33/54373

Abstract: Tightly focused beams of laser light are used as "optical tweezers" to trap and manipulate polarizable objects such as microspheres of glass or latex with diameters on the order of 4.5 mu m. When analytes are allowed to adhere to the microspheres, small quantities of these analytes can be manipulated, thus allowing their detection and quantitation even when amounts and concentrations of the analytes are extremely small. Illustrative examples include measuring the strength needed to break antibody-antigen bonds and the detection of DNA sequences.

Abstract translation: 紧密聚焦的激光束被用作“光学镊子”以捕获和操纵可极化物体，例如直径为4.5μm的玻璃或胶乳微球。 当允许分析物粘附到微球时，可以操纵少量的这些分析物，从而即使当分析物的量和浓度非常小时也能够进行检测和定量。 示例性实例包括测量断裂抗体 - 抗原键所需的强度和DNA序列的检测。

公开(公告)号：WO1996025835A1

公开(公告)日：1996-08-22

申请号：PCT/FR1996000251

申请日：1996-02-15

Applicant: CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE ,  DIMARCQ, Noël

Inventor： CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE

IPC: H05H03/04

CPC classification number: H05H3/04 ,  G04F5/14

Abstract: The invention pertains to a device for the three dimensional cooling of an atom vapour, characterised in that it comprises a cell (2) for containing the atom vapour to be cooled and means (12) for transmitting isotropic laser radiation at least to a portion of the cell. The invention is particularly useful for atomic clocks.

Abstract translation: 本发明涉及一种用于原子蒸汽的三维冷却的装置，其特征在于，其包括用于容纳要冷却的原子蒸气的电池（2）和用于将各向同性激光辐射传输至少至少部分 细胞。 本发明对原子钟特别有用。