公开(公告)号：WO2022003592A1

公开(公告)日：2022-01-06

申请号：PCT/IB2021/055866

申请日：2021-06-30

Applicant: ADL FARMACEUTICI S.R.L.

Inventor： VALLEFUOCO, Fara

IPC: A61M11/00 ,  A61M11/001 ,  A61M11/007 ,  A61M2210/0618 ,  A61M2210/065 ,  A61M2240/00

Abstract: A syringe nasal atomizer, aimed at medicating the airways, of the type which allows topical treatment s of the nasal and sinus cavities, introducing the liquid contained in the syringe into a nostril by pushing the piston, characterized in that, unlike what is known, in addition to the ostiomeatal complex (COM) and the sphenoethmoidal recess (RSE), it also allows the administration of a liquid intranasally on the nasopharynx (RF), thus ensuring a modular and progressive dispensing for the entire application time. Such a result is obtained as the atomizer is structured so as to allow the formation of liquid particles or micelles of a size between 70 and 10 microns, with an oversized cumulative percentage of mass with respec t to 10 microns of over 98%, which experimentally allows the same micelles to reach the nasopharynx in order to medicate the whole rhino-sinus-pharyngeal district, but minimizes the risk that they can reach the lower respiratory tract.

公开(公告)号：WO2022066802A8

公开(公告)日：2022-03-31

申请号：PCT/US2021/051598

申请日：2021-09-22

Applicant: AVALYN PHARMA INC.

Inventor： SURBER, Mark William ,  PHAM, Stephen

IPC: A61M11/00 ,  A61M16/00 ,  A61M15/00 ,  A61K9/00 ,  A61M11/001 ,  A61M11/005 ,  A61M15/0015 ,  A61M15/0018 ,  A61M15/0085 ,  A61M15/0086 ,  A61M2016/0024 ,  A61M2209/06

Abstract: Disclosed herein is a nebulizer comprising of a medicine cup reservoir containing an aqueous pirfenidone solution a medicine cup reservoir cap, an aerosol generator, an aerosol mixing chamber to which freshly generated aerosol resides until inhaled, a one-way inhalation valve, a mouthpiece and a one-way exhalation valve. The invention allows atmospheric pressure to be maintained inside the medicine cup reservoir during nebulization and optimizes the volume of the aerosol mixing chamber to minimize freshly generated aerosol inter-droplet collision, impaction of aerosol to the aerosol mixing chamber wall, droplet growth and/or condensation during exhalation, prior to inhalation, or during inhalation. The larger aerosol mixing chamber volume also allows the aerosol to accumulate during the exhalation phase. Despite venting producing a larger generated aerosol droplet population mean compared to the non-vented aerosol generator, The combined effect of the invention increases device output rate of respirable aerosol droplets, increases pirfenidone Cmax and AUC to improve treatment or prevention of various diseases, including disease associated with the lung, heart and kidney, including fibrosis, inflammatory conditions and transplant rejection.

公开(公告)号：WO2021221967A1

公开(公告)日：2021-11-04

申请号：PCT/US2021/028306

申请日：2021-04-21

Applicant: NORDSON CORPORATION

Inventor： GEPPERT, Kevin

IPC: B05B1/34 ,  A61M11/00 ,  A61M11/001 ,  A61M13/00 ,  A61M2206/16 ,  B05B1/3415 ,  B05B1/3436 ,  B05B1/3447

Abstract: In one example, an insert of a spray tip has a first body including at least one flute and a second body including at least one opening, with the first and second bodies spaced apart such that a channel is defined therebetween. In one example, a spray tip has a housing defining a housing channel and an insert having first and second bodies positioned within the housing channel between an inlet and an exit orifice of the housing channel. In another example, a spray tip has a housing defining a housing channel and an insert having a body positioned within the housing channel between an inlet and an exit orifice of the housing channel, the exit orifice having a cross-sectional dimension increasing as the exit orifice extends along a distal direction such that the exit orifice tapers outwardly as the exit orifice extends along the distal direction.

公开(公告)号：WO2023278551A1

公开(公告)日：2023-01-05

申请号：PCT/US2022/035492

申请日：2022-06-29

Applicant: PNEUMA RESPIRATORY, INC.

Inventor： HEBRANK, John H. ,  CLEMENTS, Judson Sidney

IPC: A61M11/00 ,  A61M15/00 ,  A61M15/06 ,  A24F40/10 ,  A24F40/05 ,  A24F40/53 ,  A24F40/85 ,  A24F40/42 ,  A24F40/48 ,  A24F40/51 ,  A24F40/60 ,  A61M11/001 ,  A61M11/005 ,  A61M15/0005 ,  A61M15/0085 ,  A61M2205/332 ,  A61M2205/3331 ,  A61M2205/43 ,  A61M2205/50 ,  A61M2205/502 ,  A61M2205/581 ,  A61M2205/583 ,  A61M2205/6018 ,  A61M2230/63

Abstract: A droplet delivery device with an ejector mechanism and fluid reservoir includes an accelerometer to determine and communicate optimized mixing of fluid in the reservoir for inhalation of droplets, such as into the lungs, from the droplet delivery device.

公开(公告)号：WO2021195117A1

公开(公告)日：2021-09-30

申请号：PCT/US2021/023737

申请日：2021-03-23

Applicant: BOSTON SCIENTIFIC SCIMED, INC.

Inventor： NAM, Ra ,  SOUKALOPOULOS, Tony ,  HUBBARD, Dennis, Brian ,  SUON, Naroun

IPC: A61B17/00 ,  A61M11/02 ,  A61M13/00 ,  A61B17/00491 ,  A61B2017/00522 ,  A61B2017/00544 ,  A61B2017/2923 ,  A61M11/001 ,  A61M11/003 ,  A61M11/007 ,  A61M2202/0225 ,  A61M2202/064

Abstract: A medical device that includes a handle for conveying an agent having particles and a receiver having a first lumen defined by a first end and a second end. The receiver having an axis extending between the first end and the second end. The first end configured to receive the particles from the handle, and the second end in fluid communication with a second lumen having a cross-sectional dimension smaller than a cross-sectional dimension of the first lumen. Each of the cross- sectional dimensions of the first lumen and the second lumen is measured transverse to the axis. The second end is configured to receive the particles from the first end of the receiver. The second lumen is configured to control delivery of the agent to a delivery conduit in fluid communication with the second lumen based on sizes of the particles.