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    NON-COORDINATING ANION TYPE ACTIVATORS CONTAINING CATION HAVING BRANCHED ALKYL GROUPS
    2.
    发明申请
    NON-COORDINATING ANION TYPE ACTIVATORS CONTAINING CATION HAVING BRANCHED ALKYL GROUPS 审中-公开

    公开(公告)号：WO2019210030A1

    公开(公告)日：2019-10-31

    申请号：PCT/US2019/029061

    申请日：2019-04-25

    Applicant: EXXONMOBIL CHEMICAL PATENTS INC.

    Inventor： FALER, Catherine, A. ,  WHALLEY, Margaret, T. ,  HAGADORN, John, R.

    IPC: C07C211/64 ,  C07F5/02 ,  C08F110/06 ,  C08F210/06 ,  C08F210/18 ,  C08F4/52 ,  C08F4/64 ,  C08F4/70

    Abstract: The present disclosure provides borate or aluminate activators comprising cations having branched alkyl groups, catalyst systems comprising, and methods for polymerizing olefins using such activators. Specifically, the present disclosure provides activator compounds represented by Formula: [R 1 R 2 R 3 EH] d +[M k +Q n ] d- , wherein: E is nitrogen or phosphorous; d is 1, 2 or 3; k is 1, 2, or 3; n is 1, 2, 3, 4, 5, or 6; n - k = d; each of R 1 , R 2 , and R 3 is independently C 1 -C 40 branched or linear alkyl or C 5 -C 50 -aryl, wherein each of R 1 , R 2 , and R 3 is independently unsubstituted or substituted with at least one of halide, C 5 -C 50 aryl, C 6 -C 35 arylalkyl, C 6 -C 35 alkylaryl and, in the case of the C 5 -C 50 -aryl, C 1 -C 50 alkyl; wherein R 1 , R 2 , and R 3 together comprise 15 or more carbon atoms; M is an element selected from group 13 of the Periodic Table of the Elements; and each Q is independently a hydride, bridged or unbridged dialkylamido, halide, alkoxide, aryloxide, hydrocarbyl, substituted hydrocarbyl, halocarbyl, substituted halocarbyl, or halosubstituted-hydrocarbyl radical, provided that at least one of R 1 , R 2 , and R 3 is a branched alkyl.

    N-(4-(BIS(4-(DIMETHYLAMINO)PHENYL)METHYLENE)-8-(DIMETHYLAMINO) NAPHTHALEN-1(4H)-YLIDENE)-N-METHYLMETHANAMINIUM, DERIVATIVES, AND THEIR USE IN TREATING CANCER
    5.
    发明申请
    N-(4-(BIS(4-(DIMETHYLAMINO)PHENYL)METHYLENE)-8-(DIMETHYLAMINO) NAPHTHALEN-1(4H)-YLIDENE)-N-METHYLMETHANAMINIUM, DERIVATIVES, AND THEIR USE IN TREATING CANCER 审中-公开
    N-（4-（二（甲基氨基）苯基）甲基）-8-（二甲基氨基）萘-1-基]（4H） - 亚胺基）-N-甲基吗啉，衍生物及其在治疗癌症中的用途

    公开(公告)号：WO2014176510A3

    公开(公告)日：2016-03-17

    申请号：PCT/US2014035470

    申请日：2014-04-25

    Applicant: UNIV EMORY

    Inventor： ARBISER JACK L

    IPC: C07C211/64 ,  A61K31/13 ,  A61K31/14 ,  A61P35/00 ,  C07C15/24

    CPC classification number: C07C251/30 ,  A61K31/15 ,  A61K45/06 ,  C07C251/22 ,  C07C2602/10 ,  C07D223/28 ,  C09B11/12

    Abstract: This disclosure relates to N-(4-(bis(4-(dimethylamino)phenyl)methylene)-8-(dimethylamino)naphthalen-1(4H)-ylidene)-N-methylmethanaminium, derivative and uses related thereto. In certain embodiments, the disclosure relates to compounds of formula I. In certain embodiments, the disclosure relates to methods of treating or preventing Nox related diseases and conditions comprising administering an effective amount of compounds disclosed herein to a subject in need thereof. In certain embodiments, the Nox related disease or condition is cancer.

    Abstract translation: 本公开涉及N-（4-（二（4-（二甲基氨基）苯基）亚甲基）-8-（二甲基氨基）萘-1（4H） - 亚基）-N-甲基甲胺，其相关用途。 在某些实施方案中，本公开涉及式I化合物。在某些实施方案中，本公开涉及治疗或预防Nox相关疾病和病症的方法，包括向有需要的受试者施用有效量的本文公开的化合物。 在某些实施方案中，Nox相关疾病或病症是癌症。

    POSITIVELY CHARGED WATER-SOLUBLE PRODRUGS OF ACETAMINOPHEN AND RELATED COMPOUNDS WITH VERY FAST SKIN PENETRATION RATE
    6.
    发明申请
    POSITIVELY CHARGED WATER-SOLUBLE PRODRUGS OF ACETAMINOPHEN AND RELATED COMPOUNDS WITH VERY FAST SKIN PENETRATION RATE 审中-公开
    具有非常快速皮肤渗透率的乙酰氨基酚和相关化合物的积极充电水溶性产品

    公开(公告)号：WO2008029200A1

    公开(公告)日：2008-03-13

    申请号：PCT/IB2006/053091

    申请日：2006-09-03

    Applicant: TECHFIELDS BIOCHEM CO. LTD ,  YU, Chongxi ,  XU, Lina

    Inventor： YU, Chongxi ,  XU, Lina

    IPC: C07C211/64 ,  C07C215/42 ,  C07C233/07

    CPC classification number: C07C233/25 ,  A61P11/06 ,  A61P17/00 ,  A61P27/06 ,  A61P27/16 ,  A61P29/00 ,  A61P35/00

    Abstract: The novel positively charged pro-drugs of acetaminophen, acetaminosalol, and related compounds in the general formula (1) 'Structure 1' were designed and synthesized. The positively charged amino groups of these pro-drugs not only largely increases the solubility of the drugs, but also bonds to the negative charge on the phosphate head group of membranes and pushes the pro-drug into the cytosol. The results suggest that the pro-drugs diffuses through human skin ~150 times faster than does acetaminophen, acetaminosalol, and related compounds. It takes 1-2 hours for acetaminophen and acetaminosalol, and related compounds to reach the peak plasma level when they are taken orally, but these prodrugs only took about ~50 minutes to reach the peak plasma level when they are taken transdermally. In plasma, more than 90% of these pro-drugs can be changed back to the parent drugs in a few minutes. The prodrugs can be used medicinally for treating any NSAIAs-treatable conditions in humans or animals. The prodrugs can be administered not only orally, but also transdermally for any kind of medical treatments and avoid most of the side effects of NSAIAs. Controlled transdermal administration systems of the prodrugs enables acetaminophen, acetaminosalol, and related compounds to reach constantly optimal therapeutic blood levels to increase effectiveness and reduce the side effects of acetaminophen, acetaminosalol, and related compounds. Another great benefit of transdermal administration of these pro-drugs is that administering medication, especially to children, will be much easier.

    Abstract translation: 设计并合成了通式（1）“结构1”中对乙酰氨基酚，乙酰氨基酚和相关化合物的新型带正电荷的前药。 这些前药的带正电荷的氨基不仅大大增加了药物的溶解度，而且还与磷酸盐头基团上的负电荷键合，并将前药推入细胞溶质中。 结果表明，前药通过人体皮肤扩散比对乙酰氨基酚，乙酰氨基酚和相关化合物快约150倍。 对乙酰氨基酚和乙酰氨基奥沙罗芬需要1-2小时，口服相关化合物达到峰值血浆水平，但这些前药在经皮摄取后仅花费约50分钟达到峰值血浆水平。 在血浆中，超过90％的这些前药可以在几分钟内更换回母体药物。 前药可用于医学上用于治疗人或动物中任何NSAIAs可治疗的病症。 前药不仅可以口服给药，也可以经皮给予任何类型的药物治疗，并避免NSAIAs的大部分副作用。 前药的受控经皮给药系统使对乙酰氨基酚，乙酰氨基酚和相关化合物达到不断优化的治疗血液水平，以增加对乙酰氨基酚，乙酰氨基酚和相关化合物的效力并降低副作用。 经皮给药这些前药的另一大好处是给予药物，尤其是给儿童服用药物将容易得多。

    NOVEL COMPOSITIONS FOR ISOLATING AND/OR STABILISING NUCLEIC ACIDS IN BIOLOGICAL MATERIAL
    7.
    发明申请
    NOVEL COMPOSITIONS FOR ISOLATING AND/OR STABILISING NUCLEIC ACIDS IN BIOLOGICAL MATERIAL 审中-公开
    新的组成为隔离和/或稳定NUCLEIC生物材料

    公开(公告)号：WO02000599A1

    公开(公告)日：2002-01-03

    申请号：PCT/EP2001/005888

    申请日：2001-05-22

    IPC: C12N15/09 ,  C07C211/62 ,  C07C211/63 ,  C07C211/64 ,  C07F9/54 ,  C12N15/00 ,  C12N15/10 ,  C12P19/34 ,  C12R1/19 ,  G01N33/50 ,  C11D3/00

    CPC classification number: C12N15/1003 ,  C07C211/62 ,  C07C211/63 ,  C07C211/64 ,  C07F9/54

    Abstract: The invention relates to novel compositions for isolating and/or stabilising nucleic acids in material of a biological origin. Said compositions comprise a cationic compound of general formula Y R1R2R3R4 X' as an essential constituent; wherein Y can represent nitrogen or phosphorus; R1, R2, R and R4 can independently represent an unbranched or branched C1-C20 alkyl radical and/or a C6-C20 aryl radical and a C6-C26 aralkyl radical; and X' can represent an anion pertaining to an inorganic or organic, monobasic or polybasic acid.

    Abstract translation: 本发明涉及用于在生物来源的材料分离和/或核酸的稳定化的新组合物。 该组合物包含作为必要组分的一般式Y <+> R1R2R3R4 X“的阳离子化合物; 其中Y是氮或磷; R1，R2，R <3>和R 4独立地为直链或支链的C1-C20-烷基和/或C6-C20芳基和C6-C26芳烷基和X“是无机或有机的，单 - 或的阴离子 可以意味着多元酸。

    VERFAHREN ZUR HERSTELLUNG VON TRIARYL-ORGANOBORATEN
    9.
    发明申请
    VERFAHREN ZUR HERSTELLUNG VON TRIARYL-ORGANOBORATEN 审中-公开
    制备三芳基有机硼酸酯的方法

    公开(公告)号：WO2018087064A1

    公开(公告)日：2018-05-17

    申请号：PCT/EP2017/078415

    申请日：2017-11-07

    Applicant: COVESTRO DEUTSCHLAND AG

    Inventor： RÖLLE, Thomas ,  BERNETH, Horst ,  HÖNEL, Dennis ,  BRUDER, Friedrich-Karl ,  KINTRUP, Jürgen

    IPC: C07D309/34 ,  C07C271/16 ,  C07C271/20 ,  C07C271/24 ,  C07C271/28 ,  C07F9/54 ,  C07D233/58 ,  C07D335/02 ,  C07D347/00 ,  C07C211/63 ,  C07C211/64 ,  C07C217/18 ,  C07C219/06 ,  C07C219/14 ,  C07C229/12 ,  C07C381/12 ,  C07F5/02 ,  C07D213/02 ,  G03F7/035 ,  G03H1/00 ,  G03C1/08 ,  G11B7/0065 ,  C07C25/18 ,  C07D233/02 ,  C07D247/00

    Abstract: Die Erfindung betrifft ein Verfahren zur Herstellung von Triarylorganoboraten ausgehend von Organo-Boronsäureestern in Gegenwart eines n-wertigen Kations 1/n K n+ umfassend die wasserfreie Aufarbeitung des Reaktionsgemischs und die Verwendung der erhaltenen Triaryl-organoboraten als Coinitiator in Photopolymer-Formulierungen, holographischen Medien und Hologrammen. Da beanspruchte Verfahren betrifft die Vorlage eine Alkyl oder Cycloalkylboronsäureesters der Formel: B-R'(OR2)(OR3) in einem aprotischen Lösungsmittel in Gegenwart eines Metalles, Zugabe des Arylhalogenids zur in situ Erzeugung einer metallorganischen Verbindung, Zugabe eines Liganden zur Umsalzung und Abtrennung der anfallenden Metallsalze und Feststoffe (Formel (A)). Weiterhin beansprucht werden Triaryl-alykborate der Formeln (C) und (CC).

    Abstract translation:

    本发明涉及一种用于从有机硼酸＆AUML制备Triarylorganoboraten的过程; ureestern在一个n价的阳离子1的存在/ Nķ N + 包含反应混合物的不含水的处理和 所得三芳基有机硼酸酯在光聚合物配方，全息介质和全息图中作为共引发剂的用途。 由于要求保护的方法的模板是指烷基或下式的Cycloalkylborons BEAR ureesters：B-R“（OR 2）（OR 3）在非质子传递L＆ouml;溶剂在金属的存在下，加入芳基卤的用于原地产生的有机金属化合物的，另外的配体的 用于再形成并分离所得到的金属盐和固体（式（A））。 还要求保护式（C）和（CC）的三芳基 - 烷基硼酸盐

    POMADA PARA COMBATIR Y TRATAR ENFERMEDADES DE LA PIEL, Y PROCEDIMIENTO DE PREPARACIÓN DE DICHA POMADA
    10.
    发明申请
    POMADA PARA COMBATIR Y TRATAR ENFERMEDADES DE LA PIEL, Y PROCEDIMIENTO DE PREPARACIÓN DE DICHA POMADA 审中-公开
    用于控制和治疗皮肤疾病的方法及其制备方法

    公开(公告)号：WO2009022041A1

    公开(公告)日：2009-02-19

    申请号：PCT/ES2008/000538

    申请日：2008-08-01

    Applicant: RAMOS PRIETO, José

    Inventor： RAMOS PRIETO, José

    IPC: A61K31/59 ,  C07C401/00 ,  A61K31/60 ,  C07C65/10 ,  A61K33/28 ,  C01G13/04 ,  A61K31/14 ,  C07C211/64 ,  A61K36/00 ,  A23D9/00 ,  A61K35/64 ,  A23L1/08

    CPC classification number: A61K36/53 ,  A61K31/305 ,  A61K31/57 ,  A61K36/515 ,  A61K36/63

    Abstract: Se describe una pomada para el tratamiento y la curación de enfermedades de la piel del ser humano, tales como psoriasis, dermatitis, acnés, herpes y hongos, consisten en una composición obtenida a base de ingredientes tales vaselina filante, clobetasol propionato, agua destilada, miel de romero, aceite de oliva virgen, mercurio cloruro precipitado blanco, ácido salicilico y violeta genciana. Asi mismo, se describe un procedimiento para preparar dicha pomada, que consiste básicamente en preparar una composición completamente homogeneizada a partir de los ingredientes mencionados, con la utilización de un dispositivo agitador, durante un tiempo del orden de 30 minutos y manteniendo la temperatura en torno a los 20°C, para obtener el aspecto cremoso o de pomada de dicha composición.

    Abstract translation: 本发明涉及一种治疗和治愈人类皮肤疾病如银屑病，皮炎，痤疮，疱疹和真菌疾病的软膏，由组合物组成，该组合物由成分如石油，丙酸氯倍他索，蒸馏水，迷迭香蜂蜜，处女橄榄 油，白色沉淀的氯化汞，水杨酸和龙胆紫。 本发明还涉及一种制备所述软膏的方法，其中在约20℃的温度下，将上述成分在搅拌器中制备完全均匀的组合物约30分钟，以生产奶油或软膏。

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