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16 条记录 (耗时 0.009 秒)

    PRACTICAL AND EFFICIENT SYNTHETIC METHOD OF RETINOIC ACID AND ITS DERIVATIVES
    2.
    发明申请
    PRACTICAL AND EFFICIENT SYNTHETIC METHOD OF RETINOIC ACID AND ITS DERIVATIVES 审中-公开
    杀真菌及其衍生物的实用有效合成方法

    公开(公告)号：WO02044140A1

    公开(公告)日：2002-06-06

    申请号：PCT/KR2001/002078

    申请日：2001-12-01

    IPC分类号： C07C317/02 ,  C07C315/02 ,  C07C315/04 ,  C07C317/06 ,  C07C317/14 ,  C07C317/44 ,  C07C319/20 ,  C07C323/65 ,  C07D311/72

    CPC分类号： C07C403/20 ,  C07C403/08 ,  C07C403/22 ,  C07C2601/16 ,  C07D311/72

    摘要： The present invention provides allylic disulfone of Chemical Formula 1, an important intermediate which can be used for syntheses of retinoids and carotenoids, a process for preparing the same, and a process for preparing retinoid compounds by using the said intermediate, and, in particular, a process for preparing retinoic acid of Chemical Formula 2 and alkyl retinoate of Chemical Formula 3. The process for preparing allylic disulfone compound of Chemical Formula 1 employs cyclo-geranyl sulfone, which reacts with C5 haloallylic sulfide to give rise to the chain-extended C15 thio-sulfone compound. The thio-sulfone compound is selectively oxidized to give allylic disulfone of Chemical Formula 1. The C15 disulfone compound reacts with C5 halo-acid or C5 halo-ester under the condition using excess base, which induces coupling and subsequent desulfonation reactions to give retinoic acid of Chemical Formula 2 or alkyl retinoate of Chemical Formula 3.

    摘要翻译： 本发明提供了化学式1的烯丙基二砜，其可用于合成类视色素和类胡萝卜素的重要中间体，其制备方法和通过使用所述中间体制备类视色素化合物的方法，特别是， 制备化学式2的视黄酸和化学式3的视黄酸的方法。化学式1的烯丙基二砜化合物的制备方法使用环芴基砜，其与C 5卤代硫代硫酸反应产生链延长的C15 硫代砜化合物。 硫代砜化合物被选择性氧化，得到化学式1的烯丙基二砜.C15二砜化合物在使用过量碱的条件下与C5卤代酸或C5卤代酯反应，引起偶联和随后的脱磺化反应，得到视黄酸 的化学式2或化学式3的视黄酸烷基酯。

    HIGH SURFACE MICROPOROUS MATERIALS WHICH ARE ACTIVE IN OXIDATION REACTIONS. TIQ-6 AND METIQ-6
    3.
    发明申请
    HIGH SURFACE MICROPOROUS MATERIALS WHICH ARE ACTIVE IN OXIDATION REACTIONS. TIQ-6 AND METIQ-6 审中-公开
    在氧化反应中活性高的高表面微孔材料。 TIQ-6和METIQ-6

    公开(公告)号：WO01037629A2

    公开(公告)日：2001-05-31

    申请号：PCT/ES2000/000456

    申请日：2000-11-24

    IPC分类号： B01J29/89 ,  B01J31/02 ,  B01J35/10 ,  B01J37/00 ,  C01B37/00 ,  C01B39/00 ,  C01B39/08 ,  C01B39/46 ,  C01B39/48 ,  C07B41/02 ,  C07B41/06 ,  C07B41/08 ,  C07B43/00 ,  C07B45/04 ,  C07B61/00 ,  C07C37/08 ,  C07C39/02 ,  C07C45/29 ,  C07C47/02 ,  C07C49/04 ,  C07C51/23 ,  C07C53/08 ,  C07C315/00 ,  C07C317/02 ,  C07D301/12 ,  C07D487/22

    CPC分类号： B01J31/0231 ,  B01J29/89 ,  B01J31/0212 ,  B01J31/0274 ,  B01J31/0275 ,  B01J31/38 ,  B01J2231/72 ,  C01B37/005 ,  C01B39/085 ,  C01B39/48 ,  C07B41/02 ,  C07B41/06 ,  C07B41/08 ,  C07B43/00 ,  C07B45/04 ,  C07D301/12 ,  Y10S423/23

    摘要： The invention relates to a microporous material formed by oxygen, silicon, germanium, aluminum, boron, gallium, zirconium and/or titanium known as TIQ-6, to a method for preparing said material and to its applications as catalyst in oxidation reactions. The TIQ-6 preparation method is based on the synthesis of a gel containing titanium and/or zirconium, hydrothermal treatment thereof under controlled conditions and treatment of the resulting laminar material with an organic compound solution, preferably having a long hydrocarbonated chain containing a proton accepting group. This swollen material is subjected to a specific treatment involving agitation, ultrasound or any other method known in prior art with the purpose of obtaining a delaminated solid with a high outer surface. The invention also relates to a material having similar characteristics as that of TIQ-6 but additionally having organic groups anchored on the surface thereof and called METIQ-6, to a method for preparing the latter and to the utilization thereof as catalyst in oxidation reactions. The incorporation of organic species during synthesis of the material called METIQ-6 is carried out by means of a post-synthesis process on the TIQ-6 material.

    摘要翻译： 本发明涉及一种由氧，硅，锗，铝，硼，镓，锆和/或钛称为TIQ-6形成的微孔材料，用于制备所述材料的方法及其在氧化反应中作为催化剂的应用。 TIQ-6制备方法是基于合成含有钛和/或锆的凝胶，在受控条件下进行水热处理，并用有机化合物溶液处理所得的层状材料，优选具有含有质子接受的长烃链 组。 该溶胀材料经受涉及搅拌，超声波或现有技术中已知的任何其它方法的具体处理，目的是获得具有高外表面的分层固体。 本发明还涉及具有与TIQ-6类似的特征的材料，但另外具有锚固在其表面上的称为METIQ-6的有机基团，其制备方法和用作氧化反应中的催化剂的方法。 在称为METIQ-6的材料的合成期间掺入有机物质是通过对TIQ-6材料的后合成方法进行的。

    SUBSTITUTED (E)-STYRYL BENZYLSULFONES FOR TREATING PROLIFERATIVE DISORDERS
    9.
    发明申请
    SUBSTITUTED (E)-STYRYL BENZYLSULFONES FOR TREATING PROLIFERATIVE DISORDERS 审中-公开
    用于治疗增殖性疾病的替代（E） - 氨苄青霉素

    公开(公告)号：WO02028828A1

    公开(公告)日：2002-04-11

    申请号：PCT/US2001/031337

    申请日：2001-10-05

    IPC分类号： A61P9/10 ,  A61K31/04 ,  A61K31/10 ,  A61K31/136 ,  A61P35/00 ,  A61P37/06 ,  C07C317/10 ,  C07C317/18 ,  C07C317/28 ,  C07C317/00 ,  C07C317/02

    CPC分类号： C07C317/18 ,  A61K31/10 ,  C07C317/10 ,  C07C317/28

    摘要： (E)-Styryl benzylsulfones useful as antiproliferative agents, including, for example, anticancer agents, are provided according to formula I: wherein: R1 is selected from the group consisting of halogen, C1-C6 alkoxy, nitro, phosphonato, amino, sulfamyl, carboxy, acetoxy and dimethylamino (C2-C6 alkoxy); and R2 and R3 are independently selected from the group consisting of halogen, C1-C6 alkoxy, C1-C6 alkyl, nitro, cyano, hydroxy, phosphonato, amino, sulfamyl, carboxy, acetoxy, and dimethylamino (C2-C6 alkoxy); provided: R1 may not be halogen when R2 and R3 are both halogen; R2 may not be 2-halogen when R3 is 4-halogen; or a pharmaceutically acceptable salt thereof; or formula II: whrein: R4 is selected from the group consisting of C1-C6 alkoxy, phosphonato, amino, sulfamyl, carboxy, acetoxy and dimethylamino (C2-C6 alkoxy); R6 is selected from the group consisting of nitro, hydrogen, phosphonato, amino, sulfamyl, carboxy, acetoxy and dimethylamino (C2-C6 alkoxy); and R7 is selected from the group consisting of halogen, C1-C6 alkoxy, C1-C6 alkyl, nitro, cyano, hydroxy, phosphonato, amino, sulfamyl, carboxy, acetoxy, dimethylamino (C2-C6 alkoxy) and trifluoromethyl; provided R5 and R6 may not be hydrogen in the same compound; or a pharmaceutically acceptable salt thereof.

    摘要翻译： （E）根据式I提供了可用作抗增殖剂的抗增生剂的酪氨酸苄基砜：其中：R 1选自卤素，C 1 -C 6烷氧基，硝基，膦酰基，氨基，亚磺酰基 ，羧基，乙酰氧基和二甲基氨基（C 2 -C 6烷氧基）; R 2和R 3独立地选自卤素，C 1 -C 6烷氧基，C 1 -C 6烷基，硝基，氰基，羟基，膦酰基，氨基，氨基磺酰基，羧基，乙酰氧基和二甲基氨基（C 2 -C 6烷氧基）。 条件是：当R 2和R 3都是卤素时，R 1可以不是卤素; 当R3为4-卤素时，R2不为2-卤素; 或其药学上可接受的盐; 或者式II：其中R 4选自C 1 -C 6烷氧基，膦酰基，氨基，氨基磺酰基，羧基，乙酰氧基和二甲基氨基（C 2 -C 6烷氧基）。 R 6选自硝基，氢，膦酰基，氨基，氨基磺酰基，羧基，乙酰氧基和二甲基氨基（C 2 -C 6烷氧基）; 氰基，羟基，膦酰基，氨基，氨基磺酰基，羧基，乙酰氧基，二甲基氨基（C 2 -C 6烷氧基）和三氟甲基; R 7选自卤素，C 1 -C 6烷氧基，C 1 -C 6烷基， 条件是R5和R6可能不是同一化合物中的氢; 或其药学上可接受的盐。