-
公开(公告)号：WO2023042070A1
公开(公告)日：2023-03-23
申请号：PCT/IB2022/058615
申请日：2022-09-13
发明人： DIJKSTRA, Stephan , THERON, Grant De Vos , NIEUWOUDT, Martinus Johannes , VENTER, Rouxjeane , WARREN, Robin Mark
摘要： An extraction device assembly for extracting a sample from a sample-containing chamber of a nucleic acid amplification cartridge is provided. The assembly has a cartridge interface forming a receptacle configured to at least partially fit the sample-containing chamber therein. The cartridge interface has an aperture configured to at least partially expose the sample-containing chamber, and a collection interface having an aperture configured to at least partially align with the cartridge interface aperture and with the sample-containing chamber positioned at least partially between them. The collection interface aperture is in fluid communication with a collector. The extraction device assembly is operable to fit the sample-containing chamber in the receptacle of the cartridge interface and guide a piercing tool into the cartridge interface aperture to pierce the sample-containing chamber and liberate a sample contained therein for transferral to the collector.
-
公开(公告)号：WO2022269530A1
公开(公告)日：2022-12-29
申请号：PCT/IB2022/055826
申请日：2022-06-23
摘要： An apparatus (100, 200) and system (300) for measuring and monitoring fouling parameters in a fluid are provided. The apparatus (100, 200) includes a conduit (103, 203) within a housing (101, 201), wherein at least a portion of the conduit provides a carbon dioxide permeable membrane through which carbon dioxide in the fluid can permeate in use. A carbon dioxide sensor (113, 213) within the housing is configured to measure carbon dioxide levels at the sensor. The housing further includes a light source (115, 215) that irradiates a portion of the conduit and a light sensor (117, 217) that is configured to measure light transmitted through or reflected by the irradiated portion of the conduit to measure the amount of fouling material within the fluid and attached to the irradiated portion of the conduit in use.
-
公开(公告)号：WO2020121211A1
公开(公告)日：2020-06-18
申请号：PCT/IB2019/060650
申请日：2019-12-11
摘要： A heat transfer device (100) includes an inner tube (102) mounted within a tubular chamber (104) of a heat exchanger (106). The hollow tubular chamber (104) has a closed end (108) with inwardly sloping inner surfaces (110) and the inner tube (102) has an open end (112) that terminates short of the closed end (108). A diffuser (114) is provided and is shaped such that an operatively front part (116) thereof substantially conforms to a shape of the inner surfaces (110) of the closed end (108) so as to form a narrow flow passageway (118) between the diffuser (114) and the inner surfaces (110) at the closed end (108), and an operatively back part (120) of the diffuser (114) slopes towards the inner tube (102) and away from its open end (112) to form a diffusion zone (122). Heat transfer assemblies utilising the heat transfer device (100) are also disclosed.
-
公开(公告)号：WO2019186452A1
公开(公告)日：2019-10-03
申请号：PCT/IB2019/052542
申请日：2019-03-28
摘要： An enzyme-polymer conjugate having the structure of Formula (I) in which f, i and k are each independently an integer from 1 to 19; g and j are each independently an integer from 0 to 100; l is an integer from 1 to 100; n is an integer from 5 to 1000; and R 1 is a hydrolase enzyme and R 2 is OH or O-, or R 1 is OH or O- and R 2 is a hydrolase enzyme is provided. The conjugate is characterised in that in at least some of subunits n, the hydrolase enzyme is an amylase, and in other subunits n, the hydrolase enzyme is a protease. The conjugate may be suitable for use in a biotechnological process or for protecting a surface from biofouling.
-
公开(公告)号：WO2019092677A1
公开(公告)日：2019-05-16
申请号：PCT/IB2018/058903
申请日：2018-11-13
摘要： A method of detecting inflammation in a subject is provided. The method comprises determining a quantity of amyloid present in fibrin(ogen) protein in a blood sample obtained from the subject, and assigning a level of inflammation in the subject based on the quantity of fibrin(ogen) amyloid determined. A method of determining an effect of a therapeutic treatment on a subject by comparing a pre-treatment level of inflammation with a post-treatment level is further provided.
-
公开(公告)号：WO2019073460A1
公开(公告)日：2019-04-18
申请号：PCT/IB2018/057976
申请日：2018-10-15
摘要： A probiotic composition comprising Bacillus amyloliquefaciens, Enterococcus faecalis, Lactobacillus salivarius, Lactobacillus johnsonii, Lactobacillus gallinarum and Lactobacillus crispatus is provided. The probiotic composition stimulates the immune response of chickens without negatively affecting growth performance. The probiotic composition can be added to poultry feed to improve the health and performance of chickens, and can be used as a replacement for antibiotic supplementation.
-
公开(公告)号：WO2019043475A3
公开(公告)日：2019-03-07
申请号：PCT/IB2018/055767
申请日：2018-08-01
IPC分类号： A61B3/113
摘要： A device and method for use in diagnosing a medical condition are described. The device includes a casing configured for mounting a communication device on a head of a patient and providing an optical path between an eye of the patient and a display zone in which a display of the communication device operatively locates. The casing includes a lens located in the optical path and configured to facilitate focussing of the eye of the patient at the display zone. The casing includes an illumination module configured to project light onto the eye and an optical arrangement. The optical arrangement is arranged to direct light, having projected onto the eye by the illumination module and reflected by the eye, towards an opening arranged operatively to provide optical communication with a camera of the communication device, thereby to enable tracking of movement of the eye by the communication device.
-
公开(公告)号：WO2019034920A1
公开(公告)日：2019-02-21
申请号：PCT/IB2017/056115
申请日：2017-10-04
CPC分类号： A61K38/1709 , A61P3/10
摘要： A method for treating a subject suffering from diabetes is provided. The method includes administering to the subject a therapeutically effective amount of lipopolysaccharide-binding protein (LBP). A composition including a therapeutically effective amount of LBP is also provided.
-
公开(公告)号：WO2017195130A1
公开(公告)日：2017-11-16
申请号：PCT/IB2017/052732
申请日：2017-05-10
IPC分类号： G01N33/68
CPC分类号： G01N33/6893 , G01N2500/00 , G01N2500/02 , G01N2800/24 , G01N2800/2821 , G01N2800/2835 , G01N2800/32 , G01N2800/52
摘要： A method for measuring autophagosome flux is provided. The autophagosome pool size in a single cell is quantified, where the pool size is the total number of autophagosomes in the cell. Fusion between the autophagosomes and lysosomes in the cell is then inhibited. The autophagosome pool size is quantified over one or more time points after fusion has been inhibited, and the autophagosome flux is calculated as the initial rate of change of the autophagosome pool size at the time point after fusion has been inhibited. The method can be used to determine basal autophagosome flux, whether a cell is diseased or dysfunctional, or to diagnose a subject with a disease, disorder or dysfunction. The transition time, the time required to clear an autophagosome pool, can also be derived from the autophagosome flux. A molecule can also be characterized according to its ability to modulate autophagosome flux in a cell.
摘要翻译： 提供了测量自噬体通量的方法。 量化单个细胞中的自噬体库大小，其中库大小是细胞中自噬体的总数。 然后抑制细胞中自噬体和溶酶体之间的融合。 在融合被抑制后，在一个或多个时间点上定量自噬体库大小，并且计算自噬体通量，作为在融合被抑制后的时间点自噬体库大小的初始变化率。 该方法可用于确定基底自噬体通量，细胞是否患病或功能障碍，或诊断患有疾病，病症或功能障碍的受试者。 过渡时间，清除自噬体池所需的时间也可以来自自噬体通量。 分子也可以根据其调节细胞自噬体通量的能力来表征。
-
10.发明申请SYSTEM AND METHOD FOR DETERMINING A CUSTOMISED HEATING SCHEDULE FOR A WATER HEATER 审中-公开用于确定水加热器的定制加热计划的系统和方法
公开(公告)号：WO2016189416A1
公开(公告)日：2016-12-01
申请号：PCT/IB2016/052819
申请日：2016-05-16
CPC分类号： G05D23/1904 , F24D19/1051 , F24H9/2014
摘要： A method and system for determining a customised heating schedule for a water heater is disclosed. The method is realised by means of a sensor that is non-invasively arranged at an outlet pipe of the water heater, which is periodically sampled. In response to detecting a first predefined signal, the start of a hot water usage event is identified. Subsequently, and in response to detecting a second predefined signal, the end of a hot water usage event is identified. The time and duration of each hot water usage event is recorded in a digital memory and a usage profile of the water heater, indicating usage times at which water in the heater should be at a usage temperature is updated. Based on the usage profile, a customised heating schedule for the water heater is determined.
摘要翻译： 公开了一种用于确定热水器的定制加热方案的方法和系统。 该方法通过非侵入式布置在热水器的出口管上的传感器来实现，该传感器是周期性采样的。 响应于检测到第一预定义信号，识别热水使用事件的开始。 随后，响应于检测到第二预定义信号，识别热水使用事件的结束。 每个热水使用事件的时间和持续时间记录在数字存储器中，并且更新热水器的使用情况，指示加热器中的水应当处于使用温度的使用时间。 根据使用情况，确定热水器的定制加热方案。
-
-
-
-
-
-
-
-
-
搜索结果
151 条记录 (耗时 0.018 秒)
