公开(公告)号：WO0200663A3

公开(公告)日：2002-05-30

申请号：PCT/GB0102898

申请日：2001-06-29

Applicant: INST BIOMAR SA ,  RUFFLES GRAHAM KEITH ,  PEREZ BAZ JULIA ,  CANEDO LIBRADA MARIA ,  GARCIA GRAVALOS DOLORES ,  ROMERO FRANCISCO ,  ESPLIEGO FERNANDO

Inventor： PEREZ-BAZ JULIA ,  CANEDO LIBRADA MARIA ,  GARCIA GRAVALOS DOLORES ,  ROMERO FRANCISCO ,  ESPLIEGO FERNANDO

IPC: A61K31/366 ,  A61P31/04 ,  A61P35/00 ,  C07D493/04 ,  C07H17/08 ,  C12N1/20 ,  C12P17/18 ,  C12P19/60 ,  C12R1/03 ,  A61K31/35 ,  A61K31/70

CPC classification number: C07D493/04 ,  C07H17/08 ,  C12P17/181 ,  C12R1/03

Abstract: A novel class of antitumour compounds has been recognised based on the isolation from a new marine microbe, strain PO13-046, belonging to the genus Actinomadura sp. ), of a compound designated IB-00208. The class of the formulae (I) or (II) where R can be hydrogen, acyl, alkyl, alkenyl, aryl, benzyl, alkali metal, and/or sugar, and R and R can be hydrogen, alkyl, or together R and R form an unsaturated bond. Such compounds demonstrate an interesting activity several cancel cell lines and against Gram-positive bacteria.

Abstract translation: 已经基于与命名为IB-00208的化合物的新型海洋微生物属于属Actinomadura sp。的菌株PO13-046的分离，已经认识到一类新的抗肿瘤化合物。 式（I）或（II）的类别，其中R 1可以是氢，酰基，烷基，烯基，芳基，苄基，碱金属和/或糖，R 2和R 3可以 是氢，烷基或一起R 2和R 3形成不饱和键。 这些化合物表现出一些有趣的活性，一些取消细胞系和革兰氏阳性菌。

公开(公告)号：WO2008116368A1

公开(公告)日：2008-10-02

申请号：PCT/CN2008/000126

申请日：2008-01-17

Applicant: 中国农业科学院兰州兽医研究所 ,  中国农业科学院生物技术研究所 ,  柳纪省 ,  张志芳 ,  李志勇 ,  易咏竹 ,  殷相平 ,  白银梅 ,  李轶女 ,  李宝玉 ,  李学瑞 ,  杨彬 ,  兰喜 ,  沈桂芳

Inventor： 柳纪省 ,  张志芳 ,  李志勇 ,  易咏竹 ,  殷相平 ,  白银梅 ,  李轶女 ,  李宝玉 ,  李学瑞 ,  杨彬 ,  兰喜 ,  沈桂芳

IPC: C12N15/42 ,  C12N15/866 ,  C12N7/01 ,  C07K14/09 ,  A61K39/135 ,  A61P31/12 ,  C12R1/03

CPC classification number: C07K14/005 ,  A61K39/00 ,  C12N2710/14143 ,  C12N2770/32122

Abstract: A method for expressing antigens of foot-and-mouth disease virus in insect in vivo by using recombinant baculovirus is disclosed, which comprises: cloning different genes combination of foot-and-mouth disease virus into baculovirus carrying vector to construct transfer vector, transfecting baculovirus with the transfer vector to proceed DNA recombination, and thus to get recombinant baculovirus, infecting insect host with the recombinant baculovirus, culturing the infected insect host to express the antigens of foot-and-mouth disease virus, and then collecting and purifying the expressed antigens. The preferred genes, baculovirus carrying vector, baculovirus and insect host are selected from P1-2A3C, ORF and VP1 genes of foot-and-mouth disease virus as shown in SEQ ID NO 1, 3 or 5, pVL1393, Bombyx mori Bm-NPV-ZJ8 and larvae or pupa of Bombyx mori, respectively.

公开(公告)号：WO01064700A1

公开(公告)日：2001-09-07

申请号：PCT/JP2001/001363

申请日：2001-02-23

IPC: A61K31/7042 ,  A61K31/7048 ,  A61P31/04 ,  C07H17/04 ,  C07H17/08 ,  C12N1/20 ,  C12P19/60 ,  C12R1/03

CPC classification number: C07H17/08 ,  C12P19/60 ,  C12R1/03

Abstract: A compound JK represented by the following general formula (1) or a pharmacologically acceptable salt thereof. (In the formula, R is hydrogen or -CH3). The compound has an excellent antibacterial effect on drug-resistant bacteria such as MRSA and is useful as an antibacterial agent.

Abstract translation: 由以下通式（1）表示的化合物JK或其药理学上可接受的盐。 （式中，R为氢或-CH 3）。 该化合物对MRSA等抗药性细菌具有优异的抗菌作用，可用作抗菌剂。

公开(公告)号：WO99020781A1

公开(公告)日：1999-04-29

申请号：PCT/JP1998/004672

申请日：1998-10-15

IPC: C12P7/18 ,  C12R1/01 ,  C12R1/02 ,  C12R1/025 ,  C12R1/03 ,  C12R1/04 ,  C12R1/06 ,  C12R1/065 ,  C12R1/13 ,  C12R1/15 ,  C12R1/18 ,  C12R1/20 ,  C12R1/265 ,  C12R1/365 ,  C12R1/38 ,  C12R1/465 ,  C12R1/48 ,  C12R1/545 ,  C12R1/56 ,  C12R1/58

CPC classification number: C12P7/18

Abstract: A process for preparing xylitol, characterized by allowing a microorganism belonging to the genus Gluconobacter, Acetobacter, Achromobacter, Agrobacterium, Arthrobacter, Azotobacter, Brevibacterium, Corynebacterium, Erwinia, Flavobacterium, Micrococcus, Norcardia, Planococcus, Pseudomonas, Rhodococcus, Morganella, Actinomadura, Actinomyces, or Streptomyces and having the capability of converting D-arabitol to xylitol to act on D-arabitol and harvesting the xylitol thus produced.

Abstract translation: 一种制备木糖醇的方法，其特征在于允许属于葡糖杆菌属，醋杆菌属，无色杆菌属，农杆菌属，节杆菌属，固氮菌属，短杆菌属，棒状杆菌属，欧文氏菌属，微杆菌属，微球菌属，诺卡氏菌属，普兰克菌属，假单胞菌属，红球菌属，莫氏菌属，放线菌属 或链霉菌，并具有将D-阿拉伯糖醇转化为木糖醇作用于D-阿拉伯糖醇并收获由此产生的木糖醇的能力。

公开(公告)号：WO02000663A2

公开(公告)日：2002-01-03

申请号：PCT/GB2001/002898

申请日：2001-06-29

IPC: A61K31/366 ,  A61P31/04 ,  A61P35/00 ,  C07D493/04 ,  C07H17/08 ,  C12N1/20 ,  C12P17/18 ,  C12P19/60 ,  C12R1/03 ,  C07D493/00

CPC classification number: C07D493/04 ,  C07H17/08 ,  C12P17/181 ,  C12R1/03

Abstract: A novel class of antitumour compounds has been recognised based on the isolation from a new marine microbe, strain PO13-046, belonging to the genus Actinomadura sp. ), of a compound designated IB-00208. The class of the formulae (I) or (II) where R can be hydrogen, acyl, alkyl, alkenyl, aryl, benzyl, alkali metal, and/or sugar, and R and R can be hydrogen, alkyl, or together R and R form an unsaturated bond. Such compounds demonstrate an interesting activity several cancel cell lines and against Gram-positive bacteria.

Abstract translation: 已经基于与命名为IB-00208的化合物的新型海洋微生物属于属Actinomadura sp。的菌株PO13-046的分离，已经认识到一类新的抗肿瘤化合物。 式（I）或（II）的类别，其中R 1可以是氢，酰基，烷基，烯基，芳基，苄基，碱金属和/或糖，R 2和R 3可以 是氢，烷基或一起R 2和R 3形成不饱和键。 这些化合物表现出一些有趣的活性，一些取消细胞系和革兰氏阳性菌。

公开(公告)号：WO99042561A1

公开(公告)日：1999-08-26

申请号：PCT/EP1999/000417

申请日：1999-01-21

IPC: C12N1/20 ,  C12P17/02 ,  C12R1/01 ,  C12R1/03 ,  C12R1/045 ,  C12R1/29 ,  C12R1/465

CPC classification number: C12R1/01 ,  C12P17/02

Abstract: The present invention relates to microorganisms producing taxanes, such as paclitaxel or related taxanes, to the use of said microorganisms for the production of taxanes, and to the procedure for the isolation of said microorganisms from plants. In particular, the present invention relates to microorganisms of the Actinomycetes group producing taxanes as well as to the biologically pure cultures of a strain of the Actinomycetes group which produces taxanes. The microorganisms of Actinomycetes group are preferably belonging to the suprageneric groups of Streptomycetes, Actinoplanetes, Maduromycetes, Thermomonosporas or Nocardioforms, more preferably they are belonging to genus Streptomyces, Actinoplanes, Nocardiopsis, Micromonospora, Actinomadura or Kitasatosporia, still more preferably to the genus Kitasatosporia. A particularly preferred microorganism is Kitasatosporia sp. CECT 4991.

Abstract translation: 本发明涉及使用所述微生物生产紫杉烷类的微生物生产紫杉烷类紫杉醇或相关紫杉烷类的微生物以及从植物中分离所述微生物的方法。 特别地，本发明涉及产生紫杉烷类的放线菌属组的微生物以及产生紫杉烷类的放线菌属组的生物纯培养物。 放线菌属组的微生物优选属于链霉菌属，放线菌纲，马齿苋属，热单孢菌属或诺卡氏菌属的超重组，更优选属于链霉菌属，动植物型，诺卡氏菌属，小单孢菌属，放线菌属或小孢子虫属，还更优选属于北沙氏菌属。 特别优选的微生物是Kitasatosporia sp。 CECT 4991。

公开(公告)号：WO99005306A1

公开(公告)日：1999-02-04

申请号：PCT/EP1998/004587

申请日：1998-07-22

IPC: C12N9/88 ,  C12N1/20 ,  C12N9/78 ,  C12P13/02 ,  C12R1/01 ,  C12R1/03

CPC classification number: C12N9/88 ,  C12N9/78 ,  C12P13/02 ,  C12R1/01 ,  C12R1/03 ,  Y10S435/822 ,  Y10S435/829

Abstract: A new biotechnological process is disclosed for preparing nitriles by using micro-organisms of the species Amycolatopsis, Actinomadura or Rhodococcus.

Abstract translation: 描述了一种用于从酰胺的制备腈的新生物技术方法。 属拟无枝酸，马杜拉放线菌属或红球菌属的微生物用于此过程。