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公开(公告)号：WO2022246155A1
公开(公告)日：2022-11-24
申请号：PCT/US2022/030191
申请日：2022-05-20
Applicant: GLEGHORN, Jason, P. , MODI, Saurabh , SHIRAZI, Jasmine
Inventor： GLEGHORN, Jason, P. , MODI, Saurabh , SHIRAZI, Jasmine
IPC: G01N33/543 , G01N33/552 , G01N27/447 , C12M1/34
Abstract: The present invention provides a method for quantifying moving heterologous nanoparticles in a suspension by imaging. The quantifying method comprises acquiring at least one z-stack of images within the suspension; tracking the nanoparticles in the images to identify unique nanoparticles; and enumerating the unique nanoparticles. Also provided is a method for characterizing size distribution of moving heterologous nanoparticles in a suspension by imaging. The characterization method comprises acquiring time lapse images; tracking the nanoparticles in the images to identify unique nanoparticles; determining the locations of each of the unique particles; determining the size of each of the unique nanoparticles; and aggregating the sizes of the unique nanoparticles.
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公开(公告)号：WO2022075981A1
公开(公告)日：2022-04-14
申请号：PCT/US2020/054523
申请日：2020-10-07
Applicant: HEWLETT-PACKARD DEVELOPMENT COMPANY, L.P.
Inventor： MAKAU, Fredrick, Muya , WEISMAN, Adam, C. , KNIGHT, Douglas , VAIDYANATHAN, Rajasekar , JACQUES, Alan
Abstract: The present disclosure describes fluid-wicking membranes, methods of making fluid-wicking membranes, and flow assay membranes. In one example, a fluid-wicking membrane can include a substrate and a porous coating layer over the substrate. The porous coating layer can include silica particles bound together by a polymeric binder. The silica particles can have an average particle size from greater than 1 pm to 50 pm. The porous coating layer can also include a surface-activating agent activating surfaces of the silica particles. The surface-activating agent can include aluminum chloride hydrate, a trivalent metal oxide, a tetravalent metal oxide, or a combination thereof.
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公开(公告)号：WO2021023997A1
公开(公告)日：2021-02-11
申请号：PCT/GB2020/051887
申请日：2020-08-06
Inventor： O'SULLIVAN, Melanie , BEHRENDT, Jonathan
IPC: G01N33/52 , G01N33/532 , G01N33/543 , G01N33/552
Abstract: A light-emitting marker having a light-emitting core comprising a light-emitting material bound to a first biotin group and a biomolecule bound to a second biotin group. A protein, e.g. streptavidin or neutravidin, is bound to the first and second biotin groups. The light- emitting marker may be a light-emitting marker particle having a particulate core.
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公开(公告)号：WO2020252488A2
公开(公告)日：2020-12-17
申请号：PCT/US2020/037821
申请日：2020-06-15
Applicant: AKOYA BIOSCIENCES, INC. , DAKSHINAMOORTHY, Gajalakshmi
IPC: G01N33/53 , G01N33/552
Abstract: An apparatus attaches to a microscope slide to form an enclosed fluidic chamber with input and output ports, where a tissue or cell sample on the slide can be processed using techniques such as immunohistochemical staining. Flow of reagents within the chamber can be laminar and highly uniform across the sample surface to achieve staining that is free of gradients. The sample can be imaged prior to, during, or after any given processing step. Methods for staining and imaging a sample can be implemented through one or more rounds of labeling, label removal or erasure and imaging. Samples can be imaged many times to achieve very high multiplexing levels. Samples can be placed on an imaging apparatus at various times and removed from the imaging apparatus for certain steps.
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公开(公告)号：WO2019208711A1
公开(公告)日：2019-10-31
申请号：PCT/JP2019/017682
申请日：2019-04-25
Applicant: キヤノン株式会社
IPC: C08J7/04 , C01B33/18 , G01N33/543 , G01N33/552
Abstract: 粒子は、ポリマーを含むコア構造と、シリカを含むシェル構造と、を含み構成される粒子であって、シェル構造は、下記式（１）で示されるシラノール基を有する構造を有し、シェル構造の厚さが３ｎｍ以上１５ｎｍ以下であることを特徴とする。
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Patent Agency Ranking6.发明申请
公开(公告)号：WO2017070570A1
公开(公告)日：2017-04-27
申请号：PCT/US2016/058262
申请日：2016-10-21
Applicant: GOODYEAR, Alan, Gordon , BEROTH, Barry
Inventor： GOODYEAR, Alan, Gordon , BEROTH, Barry
IPC: C40B60/14 , G01N33/552 , C40B40/06
CPC classification number: G01N33/553 , G01N33/54346
Abstract: Textured surfaces for analytical tests such as microarrays wherein the microfeatures and microstructures of the textured surface comprise metal nanoparticles, wherein biomolecules labeled with detection moieties may further be attached to the microfeatures and microstructures. When stimulated by electromagnetic radiation, the metal nanoparticles interact with the detection moieties in a manner that allows for increased fluorescence signaling. The microfeatures and microstructures of the textured surface space the nanoparticles at distances and can help put the nanoparticles in proximity to the labeled biomolecules. The fluorescence signal intensity is amplified due to the textured surface allowing for an increase in biomolecule binding and metal nanoparticle binding, as well as the interactions of the metal nanoparticles and fluorescent molecules.
Abstract translation: 用于诸如微阵列的分析测试的纹理化表面，其中纹理表面的微观特征和微观结构包含金属纳米粒子，其中用检测部分标记的生物分子可以进一步附着到微观特征和微结构。 当受到电磁辐射刺激时，金属纳米颗粒以允许增加荧光信号传导的方式与检测部分相互作用。 纹理表面的微观特征和微观结构将纳米颗粒间隔开并且可以帮助将纳米颗粒接近标记的生物分子。 荧光信号强度由于纹理化表面而被放大，从而允许生物分子结合和金属纳米颗粒结合的增加，以及金属纳米颗粒和荧光分子的相互作用。
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公开(公告)号：WO2014085713A1
公开(公告)日：2014-06-05
申请号：PCT/US2013/072416
申请日：2013-11-27
Applicant: THE METHODIST HOSPITAL RESEARCH INSTITUTE
Inventor： HU, Ye , MA, Xin , WU, Hung-Jen , FAN, Jia , SUN, Tong
IPC: G01N33/543 , G01N33/552
CPC classification number: G01N33/5695 , G01N33/552 , G01N33/569 , G01N2333/35 , G01N2469/10
Abstract: Improved methods for detecting active tuberculosis are disclosed. A method comprises enriching at least one M. tuberculosis- specific biomolecule from a sample by contacting the sample with a nanoporous film; and detecting the presence of the M. tuberculosis-specific biomolecule or fragment(s) thereof. The method may further comprise digesting the enriched M. tuberculosis -specific biomolecule with an enzyme to produce a digestion product comprising at least one fragment of the M. tuberculosis -specific biomolecule. Improved sensitivity and speed achieved.
Abstract translation: 公开了用于检测活动性结核病的改进方法。 一种方法包括通过使样品与纳米孔膜接触来从样品中富集至少一种结核分枝杆菌特异性生物分子; 并检测结核分枝杆菌特异性生物分子或其片段的存在。 该方法还可以包括用酶消化富集的结核分枝杆菌特异性生物分子，以产生包含结核分枝杆菌特异性生物分子的至少一个片段的消化产物。 提高灵敏度和速度。
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公开(公告)号：WO2014061371A1
公开(公告)日：2014-04-24
申请号：PCT/JP2013/074272
申请日：2013-09-09
Applicant: 住友ベークライト株式会社
Inventor： 松元 孝行
IPC: G01N33/543 , G01N33/552
CPC classification number: G01N33/54353 , C08F230/08 , G01N33/543 , G01N33/545 , G01N33/552
Abstract: 本発明は、生理活性物質を固定化することができる担体、特に好ましくは、生理活性物質を固定化することができ且つ非特異吸着が抑制された担体を簡便に作製し、提供することを目的とする。本発明の分析用担体は、生理活性物質を捕捉する機能を有する分析用担体であって、担体の表面に、重合体が固定化されており、前記重合体は、側鎖に親水性基を有する第１繰り返しユニットと、側鎖の末端に活性エステル基を有する第２繰り返しユニットと、を有することを特徴とする。
Abstract translation: 本发明的目的是容易地制造和提供能够固定生物活性物质，特别优选能够固定生物活性物质并且非特异性吸附被限制的载体的载体。 该分析载体具有捕获生物活性物质的功能，其特征在于：聚合物固定在载体的表面上; 并且所述聚合物具有在侧链上具有亲水基团的第一重复单元和在侧链末端具有活性酯基的第二重复单元。
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公开(公告)号：WO2013179342A1
公开(公告)日：2013-12-05
申请号：PCT/JP2012/003561
申请日：2012-05-30
Applicant: 株式会社バイオマーカーサイエンス , 国立大学法人大阪大学 , 民谷 栄一 , 大木 誠 , 斉藤 真人 , 村橋 瑞穂 , 向井 準 , 中西 守
IPC: G01N33/553 , G01N33/543 , G01N33/552 , G01N37/00
CPC classification number: G01N33/49 , G01N33/553
Abstract: バイオチップは、上面に金属層が堆積された基板（１）と、基板（１）の上に設けられ、それぞれ並行に延びる複数の仕切部（２）と、複数の仕切部（２）の上に設けられたカバー部材（３）とを備えている。基板（１）の上には、基板（１）、仕切部（２）及びカバー部材（３）により、それぞれ並行に延びる複数の流路（４）が形成され、基板（１）の上の各流路（４）には、それぞれ複数の固相化プローブ（５）が形成されている。流路（４）における基板（１）とカバー部材（３）との間隙は、液体が毛細管現象により流路（４）の一端から他端にまで展開できる大きさである。
Abstract translation: 一种生物芯片，其具有：在上表面上沉积有金属层的基板（1） 设置在所述基板（1）上的多个分隔部（2），每个分隔部（2）以平行的方式延伸; 以及设置在所述多个分隔部（2）上的盖部件（3）。 通过基板（1），分隔部分（2）和盖部件（3）在基板（1）上形成平行地延伸的多个流动通道（4）。 多个固相形成用探针（5）以各自的方式在基板（1）上形成在流路（4）中。 衬底（1）和盖构件（3）之间的流动通道（4）中的间隙具有允许液体通过毛细管现象从流动通道（4）的一端到另一端部署的尺寸。
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公开(公告)号：WO2012159171A1
公开(公告)日：2012-11-29
申请号：PCT/AU2012/000591
申请日：2012-05-25
Applicant: MACQUARIE UNIVERSITY , SUNNA, Anwar , BERGQUIST, Peter Leonard , FERRARI, Belinda
Inventor： SUNNA, Anwar , BERGQUIST, Peter Leonard , FERRARI, Belinda
IPC: G01N33/552 , G01N33/50 , C07K17/14
CPC classification number: C07K17/14 , C12N11/14 , G01N33/552
Abstract: The present invention relates to complexes of silica-containing materials and peptide linkers for the capture of biological and chemical entities. In particular, the present invention relates to the use of complexes of silica-containing materials and peptide linkers comprising capture moieties for the capture of biological and chemical entities.
Abstract translation: 本发明涉及用于捕获生物和化学实体的含二氧化硅的物质和肽接头的复合物。 特别地，本发明涉及含二氧化硅的物质和包含捕获部分的肽接头的复合物在捕获生物和化学实体中的用途。
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