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    FLUORESCENT ENVELOPED VIRAL PARTICLES AS STANDARDS FOR NANOSALE FLOW CYTOMETRY
    1.
    发明申请
    FLUORESCENT ENVELOPED VIRAL PARTICLES AS STANDARDS FOR NANOSALE FLOW CYTOMETRY 审中-公开

    公开(公告)号：WO2019060980A1

    公开(公告)日：2019-04-04

    申请号：PCT/CA2018/000080

    申请日：2018-04-27

    Applicant: UNIVERSITY OF OTTAWA

    Inventor： LANGLOIS, Marc-André ,  TANG, Vera ,  RENNER, Tyler Milston

    IPC: C12N15/62 ,  C07K14/15 ,  C07K19/00 ,  C12N15/46 ,  C12N15/867 ,  C12N15/10 ,  C12N7/01 ,  C12Q1/6897 ,  C12Q1/70 ,  G01N15/10 ,  G01N33/48 ,  G01N33/52

    Abstract: Described herein are uses of fluorescent enveloped virus particles as standards in nanoscale flow cytometry applications. The virus particles comprise a fluorescent dye or a fluorescent protein. A standard ladder comprising a plurality of fluorescent enveloped virus particles of different sizes is also provided. The standards may also comprise marker(s) of interest, and may be used as controls for detection of other viruses or extracellular vesicle, e.g. in diagnostic applications. Methods of producing controls for such applications are provided, including those having desired profiles. The controls may be used for enumeration of markers on microparticles (e.g. extracellular vesicles or viruses). Also described is a modified gammaretrovirus comprising a mutation that abolishes expression of the viral glyco-Gag protein, and having a fluorescent protein inserted in-frame into the proline-rich region (PRR) of the viral env protein. The gammaretrovirus may be M- MLV bearing a mutation that abolishes expression of the glyco-Gal protein, gPr80.

    ROTAVIRUS SUBUNIT VACCINE
    4.
    发明申请
    ROTAVIRUS SUBUNIT VACCINE 审中-公开
    罗非鱼亚型疫苗

    公开(公告)号：WO00026380A1

    公开(公告)日：2000-05-11

    申请号：PCT/US1999/025799

    申请日：1999-11-01

    IPC: C12N15/09 ,  A61K35/76 ,  A61K38/00 ,  A61K39/00 ,  A61K39/15 ,  A61K39/39 ,  A61P1/00 ,  A61P1/04 ,  A61P31/14 ,  C07K14/14 ,  C07K19/00 ,  C12N1/15 ,  C12N1/19 ,  C12N1/21 ,  C12N5/10 ,  C12N15/46 ,  C12P21/02 ,  C12R1/19 ,  C12N15/62

    CPC classification number: C07K14/005 ,  A61K39/00 ,  C07K2319/00 ,  C12N2720/12322 ,  Y02A50/472

    Abstract: The present invention is directed to the generation and use of recombinant rotavirus fusion proteins as immunogens to produce a protective immune response from immunized individuals. In one embodiment, the present invention contemplates a recombinant rotavirus fusion protein vaccine composition comprising a rotavirus subunit protein or immunogenic fragment thereof, and an adjuvant in combination with the recombinant rotavirus subunit fusion protein. In one aspect of this embodiment, the recombinant rotavirus fusion protein comprises a rotavirus subunit protein and a fusion partner protein in genetic association with the rotavirus subunit protein, wherein the fusion partner protein does not interfere with expression and immunogenicity of the rotavirus subunit protein, the fusion partner protein prevents complex formation by the rotavirus subunit protein, and the fusion partner protein facilitates purification of the recombinant rotavirus fusion protein. In another aspect of this embodiment, the rotavirus subunit protein is selected from the group consisting of VP1, VP2, VP3, VP4, VP6, VP7, NSP1, NSP2, NSP3, NSP4 or NSP5. In yet another aspect of this embodiment, the rotavirus subunit protein is VP6.

    Abstract translation: 本发明涉及重组轮状病毒融合蛋白作为免疫原的产生和使用，以产生免疫个体的保护性免疫应答。 在一个实施方案中，本发明涉及包含轮状病毒亚基蛋白或其免疫原性片段的重组轮状病毒融合蛋白疫苗组合物，以及与重组轮状病毒亚基融合蛋白组合的佐剂。 在该实施方案的一个方面，重组轮状病毒融合蛋白包含轮状病毒亚基蛋白和与轮状病毒亚基蛋白遗传相关的融合配偶体蛋白，其中融合伴侣蛋白不干扰轮状病毒亚基蛋白的表达和免疫原性， 融合配偶体蛋白质阻止轮状病毒亚基蛋白的复合物形成，并且融合配偶体蛋白有助于重组轮状病毒融合蛋白的纯化。 在该实施方案的另一方面，轮状病毒亚基蛋白选自VP1，VP2，VP3，VP4，VP6，VP7，NSP1，NSP2，NSP3，NSP4或NSP5。 在该实施方案的另一方面，轮状病毒亚基蛋白是VP6。

    REOVIRIDAE VACCINE
    6.
    发明申请
    REOVIRIDAE VACCINE 审中-公开
    REOVIRIDAE疫苗

    公开(公告)号：WO2017187131A1

    公开(公告)日：2017-11-02

    申请号：PCT/GB2017/050994

    申请日：2017-04-10

    Applicant: LONDON SCHOOL OF HYGIENE & TROPICAL MEDICINE

    Inventor： ROY, Polly

    IPC: C12N15/46 ,  C12N7/04 ,  C12N5/10 ,  A61K31/7105 ,  A61K39/15 ,  C12N7/00

    Abstract: The invention relates to an isolated African horse sickness virus (AHSV) ssRNA comprising a plurality of mutations; a complementary cell for replication of a vaccinal viral strain from said ssRNA; a vaccinal viral strain derived from said ssRNA; use of said vaccinal viral strain and/or isolated ssRNA in the vaccination of an animal against an infectionby AHSV; a method of vaccination comprising same; and a pharmaceutical composition comprising said vaccinal viral strain and/or said isolated ssRNA.

    Abstract translation: 本发明涉及包含多个突变的分离的非洲马瘟病毒（AHSV）ssRNA; 用于从所述ssRNA复制疫苗病毒株的互补细胞; 源自所述ssRNA的疫苗病毒株; 在针对AHSV感染的动物疫苗接种中使用所述疫苗病毒株和/或分离的ssRNA; 包含它的疫苗接种方法; 和包含所述疫苗病毒株和/或所述分离的ssRNA的药物组合物。

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