The invention discloses a synthetic method for 5-methyluridine. The synthetic method is optimized based on a 5-methyluridine chemical synthesis method; the key points are that a byproduct trimethylsilyl acetate in a condensation reaction is separated, and reacts with ammonia to generate hexamethyldisilazane which can be repeatedly utilized; meanwhile, tail gas generated by the reaction is absorbed by absolute methanol to obtain aminomethanol, which can be used in an alcoholysis reaction during the synthesis of 5-methyluridine. The synthetic method for 5-methyluridine provided by the invention combines the advantages of the 5-methyluridine chemical synthesis method and optimizes the defects in production, so that on one hand, a utilization rate of a trisilicane protective group is increased, on the other hand, emission of waste liquor and waste gas is reduced, thereby overcoming the defect that the chemical synthesis method is not environment-friendly while being free of affecting the total yield.