- 专利标题： Inverse patterning process for three-dimensional multi-compartmental micro-organization of multiple cell types
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申请号： US14381866申请日： 2013-02-28
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公开(公告)号： US10072257B2公开(公告)日： 2018-09-11
- 发明人: Sangeeta N. Bhatia , Kelly R. Stevens
- 申请人： Massachusetts Institute of Technology
- 申请人地址： US MA Cambridge
- 专利权人： Massachusetts Institute of Technology
- 当前专利权人： Massachusetts Institute of Technology
- 当前专利权人地址： US MA Cambridge
- 代理机构： Nelson Mullins Riley & Scarborough LLP
- 代理商 Amy E. Mandragouras, Esq.; Ariana D. Harris
- 国际申请： PCT/US2013/028345 WO 20130228
- 国际公布： WO2013/130823 WO 20130906
- 主分类号： C12N5/00
- IPC分类号： C12N5/00 ; C12N11/04 ; C12N5/071 ; A61K35/12 ; C12N11/08 ; C12N11/10 ; G01N33/50
摘要：
The invention features an “inverse patterning” or “Intaglio-Void/Embed-Relief Topographic (In VERT) molding” manufacturing process for generating high-resolution three-dimensional (3D) multi-cellular microstructures in distinct cellular compartments of a single hydrogel. The platform has general utility in the development of engineered tissues for human therapies, drug testing, and disease models. Additionally, the platform can serve as a model system for studying 3D cell-cell interactions in fields as diverse as stem cell biology to the development of cancer therapeutics.
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