Invention Grant
- Patent Title: Use of physiological cooling active ingredients, and compositions comprising such active ingredients
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Application No.: US16642954Application Date: 2018-08-31
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Publication No.: US11434220B2Publication Date: 2022-09-06
- Inventor: Benoît Join , Jekaterina Ongouta , Michael Backes , Rahim Brodhage , Arnold Machinek , Hubert Loges , Susanne Mundt , Tom Somers , Thomas Subkowski , Jens Wittenberg , Martin Weisel , Wolfgang Siegel , Claus Bollschweiler , Ralf Pelzer
- Applicant: BASF SE , SYMRISE AG
- Applicant Address: DE Ludwigshafen am Rhein; DE Holzminden
- Assignee: BASF SE,SYMRISE AG
- Current Assignee: BASF SE,SYMRISE AG
- Current Assignee Address: DE Ludwigshafen am Rhein; DE Holzminden
- Agency: Faegre Drinker Biddle & Reath LLP
- Priority: EP17188719 20170831
- International Application: PCT/EP2018/073486 WO 20180831
- International Announcement: WO2019/043164 WO 20190307
- Main IPC: C07D317/46
- IPC: C07D317/46 ; C07C323/41 ; C07D405/12 ; C07D213/75 ; C07D231/40 ; C07D407/12 ; C07D307/14 ; C07D409/12 ; C07D409/14 ; C07D405/14 ; A61K8/49 ; A61K8/46 ; A61Q11/00 ; A23L29/00 ; A23L27/00 ; A23G3/36
Abstract:
The invention relates primarily to a method of modulation, preferably of in vitro and/or in vivo modulation, of the cold menthol receptor TRPM8, wherein the receptor is contacted with at least one modulator selected from the group consisting of the compounds of the structure type 1 described herein. The present invention further relates to corresponding uses and compositions comprising such compounds.
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