公开(公告)号：US11434220B2

公开(公告)日：2022-09-06

申请号：US16642954

申请日：2018-08-31

Applicant: BASF SE ,  SYMRISE AG

Inventor： Benoît Join ,  Jekaterina Ongouta ,  Michael Backes ,  Rahim Brodhage ,  Arnold Machinek ,  Hubert Loges ,  Susanne Mundt ,  Tom Somers ,  Thomas Subkowski ,  Jens Wittenberg ,  Martin Weisel ,  Wolfgang Siegel ,  Claus Bollschweiler ,  Ralf Pelzer

IPC: C07D317/46 ,  C07C323/41 ,  C07D405/12 ,  C07D213/75 ,  C07D231/40 ,  C07D407/12 ,  C07D307/14 ,  C07D409/12 ,  C07D409/14 ,  C07D405/14 ,  A61K8/49 ,  A61K8/46 ,  A61Q11/00 ,  A23L29/00 ,  A23L27/00 ,  A23G3/36

Abstract: The invention relates primarily to a method of modulation, preferably of in vitro and/or in vivo modulation, of the cold menthol receptor TRPM8, wherein the receptor is contacted with at least one modulator selected from the group consisting of the compounds of the structure type 1 described herein. The present invention further relates to corresponding uses and compositions comprising such compounds.

公开(公告)号：US11801210B2

公开(公告)日：2023-10-31

申请号：US17042263

申请日：2019-03-29

Applicant: SYMRISE AG

Inventor： Dominik Stuhlmann ,  Ann-Christin Weseloh ,  Nicole Titze ,  Sabine Lange ,  Sebastian Bruncke ,  Benoît Join ,  Gabriele Vielhaber ,  Marielle Le Maire ,  Karima Benaissi

IPC: A61K8/37 ,  A61P17/02 ,  A61K31/01 ,  A61K31/047 ,  A61K31/198 ,  A61K31/22 ,  A61K31/225 ,  A61K31/23 ,  A61K31/232 ,  A61K31/355 ,  A61K31/357 ,  A61K36/28 ,  A61K36/886 ,  A61K36/9068 ,  A61Q17/04 ,  A61Q19/00 ,  A61Q19/08

CPC classification number: A61K8/37 ,  A61K31/01 ,  A61K31/047 ,  A61K31/198 ,  A61K31/22 ,  A61K31/225 ,  A61K31/23 ,  A61K31/232 ,  A61K31/355 ,  A61K31/357 ,  A61K36/28 ,  A61K36/886 ,  A61K36/9068 ,  A61P17/02 ,  A61Q17/04 ,  A61Q19/00 ,  A61Q19/08

Abstract: The present invention relates to novel cosmetic and therapeutic uses of one or more compounds of the general formula (1) as described herein. Furthermore, the present invention relates to compositions (products or, respectively, formulations), in particular for topical administration, preferably cosmetic or pharmaceutical compositions, comprising or consisting of compound(s) of formula (1) and one or more cosmetically and/or pharmaceutically acceptable carriers. The present invention also relates to novel uses of such compositions according to the invention.