公开(公告)号：US11434220B2

公开(公告)日：2022-09-06

申请号：US16642954

申请日：2018-08-31

Applicant: BASF SE ,  SYMRISE AG

Inventor： Benoît Join ,  Jekaterina Ongouta ,  Michael Backes ,  Rahim Brodhage ,  Arnold Machinek ,  Hubert Loges ,  Susanne Mundt ,  Tom Somers ,  Thomas Subkowski ,  Jens Wittenberg ,  Martin Weisel ,  Wolfgang Siegel ,  Claus Bollschweiler ,  Ralf Pelzer

IPC: C07D317/46 ,  C07C323/41 ,  C07D405/12 ,  C07D213/75 ,  C07D231/40 ,  C07D407/12 ,  C07D307/14 ,  C07D409/12 ,  C07D409/14 ,  C07D405/14 ,  A61K8/49 ,  A61K8/46 ,  A61Q11/00 ,  A23L29/00 ,  A23L27/00 ,  A23G3/36

Abstract: The invention relates primarily to a method of modulation, preferably of in vitro and/or in vivo modulation, of the cold menthol receptor TRPM8, wherein the receptor is contacted with at least one modulator selected from the group consisting of the compounds of the structure type 1 described herein. The present invention further relates to corresponding uses and compositions comprising such compounds.