Invention Application
- Patent Title: TARGETED REPLACEMENT OF ENDOGENOUS T CELL RECEPTORS
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Application No.: US17725478Application Date: 2022-04-20
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Publication No.: US20220241336A1Publication Date: 2022-08-04
- Inventor: Theodore Lee ROTH , Eric SHIFRUT , Alexander MARSON , Cristina PUIG SAUS , Antoni RIBAS
- Applicant: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
- Applicant Address: US CA Oakland
- Assignee: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
- Current Assignee: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
- Current Assignee Address: US CA Oakland
- Main IPC: A61K35/17
- IPC: A61K35/17 ; C07K14/725 ; C12N9/22 ; C12N15/113 ; C12N15/85 ; C12N15/90
Abstract:
Provided herein are methods and compositions for editing the genome of a human T cell. In some embodiments, a heterologous T cell receptor (TCR)-β chain and a heterologous TCR-α chain are inserted into exon 1 of a TCR subunit constant gene in the genome of the T cell.
Public/Granted literature
- US11590171B2 Targeted replacement of endogenous T cell receptors Public/Granted day:2023-02-28
Information query
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