公开(公告)号：US20210353678A1

公开(公告)日：2021-11-18

申请号：US17390673

申请日：2021-07-30

Applicant: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA

Inventor： Theodore Lee ROTH ,  Eric SHIFRUT ,  Alexander Marson ,  Cristina PUIG SAUS ,  Antoni RIBAS

IPC: A61K35/17 ,  C07K14/725 ,  C12N9/22 ,  C12N15/113 ,  C12N15/85 ,  C12N15/90

Abstract: Provided herein are methods and compositions for editing the genome of a human T cell. In some embodiments, a heterologous T cell receptor (TCR)-β chain and a heterologous TCR-α chain are inserted into exon 1 of a TCR subunit constant gene in the genome of the T cell.

公开(公告)号：US20220241336A1

公开(公告)日：2022-08-04

申请号：US17725478

申请日：2022-04-20

Applicant: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA

Inventor： Theodore Lee ROTH ,  Eric SHIFRUT ,  Alexander MARSON ,  Cristina PUIG SAUS ,  Antoni RIBAS

IPC: A61K35/17 ,  C07K14/725 ,  C12N9/22 ,  C12N15/113 ,  C12N15/85 ,  C12N15/90

Abstract: Provided herein are methods and compositions for editing the genome of a human T cell. In some embodiments, a heterologous T cell receptor (TCR)-β chain and a heterologous TCR-α chain are inserted into exon 1 of a TCR subunit constant gene in the genome of the T cell.