公开(公告)号：US20220241336A1

公开(公告)日：2022-08-04

申请号：US17725478

申请日：2022-04-20

Applicant: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA

Inventor： Theodore Lee ROTH ,  Eric SHIFRUT ,  Alexander MARSON ,  Cristina PUIG SAUS ,  Antoni RIBAS

IPC: A61K35/17 ,  C07K14/725 ,  C12N9/22 ,  C12N15/113 ,  C12N15/85 ,  C12N15/90

Abstract: Provided herein are methods and compositions for editing the genome of a human T cell. In some embodiments, a heterologous T cell receptor (TCR)-β chain and a heterologous TCR-α chain are inserted into exon 1 of a TCR subunit constant gene in the genome of the T cell.

公开(公告)号：US20210353678A1

公开(公告)日：2021-11-18

申请号：US17390673

申请日：2021-07-30

Applicant: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA

Inventor： Theodore Lee ROTH ,  Eric SHIFRUT ,  Alexander Marson ,  Cristina PUIG SAUS ,  Antoni RIBAS

IPC: A61K35/17 ,  C07K14/725 ,  C12N9/22 ,  C12N15/113 ,  C12N15/85 ,  C12N15/90

Abstract: Provided herein are methods and compositions for editing the genome of a human T cell. In some embodiments, a heterologous T cell receptor (TCR)-β chain and a heterologous TCR-α chain are inserted into exon 1 of a TCR subunit constant gene in the genome of the T cell.

公开(公告)号：US20210317406A1

公开(公告)日：2021-10-14

申请号：US17259085

申请日：2019-07-09

Applicant: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA

Inventor： Alexander MARSON ,  Eric SHIFRUT ,  Julia CARNEVALE ,  Alan ASHWORTH

IPC: C12N5/0783 ,  A61K35/17 ,  C12N15/11 ,  C12N15/113 ,  C12N9/22

Abstract: Provided herein are genetically modified T cells that exhibit increased proliferation compared to wild-type T cells when stimulated, methods of generating such T cells, and methods of using the T cells for the treatment of a disease such as cancer.

公开(公告)号：US20200000851A1

公开(公告)日：2020-01-02

申请号：US16568116

申请日：2019-09-11

Applicant: The Regents of the University of California

Inventor： Theodore Lee ROTH ,  Eric SHIFRUT ,  Alexander MARSON ,  Cristina Puig SAUS ,  Antoni RIBAS

IPC: A61K35/17 ,  C12N15/85 ,  C12N15/90 ,  C12N9/22 ,  C12N15/113 ,  C07K14/725

Abstract: Provided herein are methods and compositions for editing the genome of a human T cell. In some embodiments, a heterologous T cell receptor (TCR)-β chain and a heterologous TCR-α chain are inserted into exon 1 of a TCR subunit constant gene in the genome of the T cell.