发明授权
- 专利标题： Microbiological synthesis of beta endorphin
- 专利标题（中）： β内啡肽的微生物合成
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申请号： US128711申请日： 1980-03-10
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公开(公告)号： US4350764A公开(公告)日： 1982-09-21
- 发明人: John D. Baxter , Ivy Fettes , John Shine
- 申请人： John D. Baxter , Ivy Fettes , John Shine
- 申请人地址： CA Berkeley
- 专利权人： The Regents of the University of California
- 当前专利权人： The Regents of the University of California
- 当前专利权人地址： CA Berkeley
- 主分类号： C12N15/09
- IPC分类号： C12N15/09 ; C07H21/04 ; C07K14/005 ; C07K14/195 ; C07K14/575 ; C07K14/655 ; C07K14/675 ; C12N1/20 ; C12P21/00 ; C12P21/02 ; C12N1/00 ; C12N15/00
摘要：
DNA comprising the naturally occurring nucleotide sequence coding for amino acids 44-90 of .beta.-lipotropin and including the entire coding region for .beta.-endorphin with the exception of the C-terminal glutamine was modified, transferred to an expression transfer vector, and expressed as a fusion protein. The fusion protein was further modified in vitro to yield mature .beta.-endorphin. .beta.-endorphin was purified from a bacterial lysate. The structure and biological activity of the resulting product was proven by immunological assay, and by two independent assays designed to demonstrate biological activity.
公开/授权文献
- US5472002A Cigarette filter for administering taurine by inhalation 公开/授权日：1995-12-05
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