发明授权
- 专利标题: Automated molecular biology laboratory
- 专利标题(中): 自动分子生物学实验室
-
申请号: US927254申请日: 1992-08-07
-
公开(公告)号: US5443791A公开(公告)日: 1995-08-22
- 发明人: G. Richard Cathcart , Thomas Brennan-Marquez , John A. Bridgham , George S. Golda , Harry A. Guiremand , Marianne Hane , Louis B. Hoff , Eric Lachenmeier , Melvyn N. Kronick , Douglas H. Keith , Paul E. Mayrand , Michael L. Metzker , William J. Mordan , Lincoln J. McBride , John Shigeura , Chen-Hanson Ting , Norman M. Whiteley
- 申请人: G. Richard Cathcart , Thomas Brennan-Marquez , John A. Bridgham , George S. Golda , Harry A. Guiremand , Marianne Hane , Louis B. Hoff , Eric Lachenmeier , Melvyn N. Kronick , Douglas H. Keith , Paul E. Mayrand , Michael L. Metzker , William J. Mordan , Lincoln J. McBride , John Shigeura , Chen-Hanson Ting , Norman M. Whiteley
- 申请人地址: CA Foster City
- 专利权人: Perkin Elmer - Applied Biosystems Division
- 当前专利权人: Perkin Elmer - Applied Biosystems Division
- 当前专利权人地址: CA Foster City
- 主分类号: B01L3/14
- IPC分类号: B01L3/14 ; G01N35/00 ; G01N35/02 ; G01N35/04 ; G01N35/10 ; G01N21/01 ; G01N1/10 ; G01N21/11 ; G01N35/08
摘要:
A liquid-handling instrument has a worksurface with registration for modular stations to support containers of liquid, pipette apparatus with a pipette tip coupled to a sensing circuit, a robotic translation system for moving the pipette tip, and a control system with an iconic user interface for programming and editing. A gauge block registered on the worksurface provides for calibration using the sensing tip, and register cavities on the worksurface provide for modular stations. There is a wash station fop the pipette tip on the worksurface. An automated laboratory based on the liquid-handling system has heating and cooling and a sealable incubation station as well as a magnetic separation station. Methods are disclosed using the apparatus to convey droplets of liquid, to aspirate with minimum tip contamination, to mix liquids in containers, and to validate the worksurface. A duck-billed closure is disclosed for minimizing evaporation and cross-contamination during processing, and is a part of a container disclosed for storing and transporting liquids.