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公开(公告)号:US5443791A
公开(公告)日:1995-08-22
申请号:US927254
申请日:1992-08-07
申请人: G. Richard Cathcart , Thomas Brennan-Marquez , John A. Bridgham , George S. Golda , Harry A. Guiremand , Marianne Hane , Louis B. Hoff , Eric Lachenmeier , Melvyn N. Kronick , Douglas H. Keith , Paul E. Mayrand , Michael L. Metzker , William J. Mordan , Lincoln J. McBride , John Shigeura , Chen-Hanson Ting , Norman M. Whiteley
发明人: G. Richard Cathcart , Thomas Brennan-Marquez , John A. Bridgham , George S. Golda , Harry A. Guiremand , Marianne Hane , Louis B. Hoff , Eric Lachenmeier , Melvyn N. Kronick , Douglas H. Keith , Paul E. Mayrand , Michael L. Metzker , William J. Mordan , Lincoln J. McBride , John Shigeura , Chen-Hanson Ting , Norman M. Whiteley
IPC分类号: B01L3/14 , G01N35/00 , G01N35/02 , G01N35/04 , G01N35/10 , G01N21/01 , G01N1/10 , G01N21/11 , G01N35/08
CPC分类号: G01N35/0099 , B01L3/50825 , G01N35/0098 , B01F2215/0037 , G01N2035/00079 , G01N2035/00237 , G01N2035/00356 , G01N2035/00435 , G01N2035/0403 , G01N2035/0475 , G01N2035/0491 , G01N2035/1013 , G01N2035/102 , G01N2035/1034 , G01N2035/1058 , G01N2035/106 , G01N35/028 , G01N35/1004 , G01N35/109 , Y10S435/809 , Y10T436/119163 , Y10T436/2575
摘要: A liquid-handling instrument has a worksurface with registration for modular stations to support containers of liquid, pipette apparatus with a pipette tip coupled to a sensing circuit, a robotic translation system for moving the pipette tip, and a control system with an iconic user interface for programming and editing. A gauge block registered on the worksurface provides for calibration using the sensing tip, and register cavities on the worksurface provide for modular stations. There is a wash station fop the pipette tip on the worksurface. An automated laboratory based on the liquid-handling system has heating and cooling and a sealable incubation station as well as a magnetic separation station. Methods are disclosed using the apparatus to convey droplets of liquid, to aspirate with minimum tip contamination, to mix liquids in containers, and to validate the worksurface. A duck-billed closure is disclosed for minimizing evaporation and cross-contamination during processing, and is a part of a container disclosed for storing and transporting liquids.
摘要翻译: 液体处理仪器具有工作表面,其具有用于模块化站的注册以支持液体容器,具有连接到感测电路的移液管尖端的移液管装置,用于移动吸头的机器人翻译系统以及具有标识用户界面的控制系统 用于编程和编辑。 在工作表面上注册的量块提供了使用感应尖端的校准,工件表面上的注册腔提供模块化站。 在工作台上有一个洗手台,用于吸取吸头。 基于液体处理系统的自动化实验室具有加热和冷却以及可密封的孵化站以及磁选机。 公开了使用装置输送液体的方法,以最小的尖端污染抽吸以将容器中的液体混合并验证工作面。 公开了一种用于最小化加工期间的蒸发和交叉污染的鸭嘴盖,并且是用于储存和运输液体的容器的一部分。