发明授权
US5464759A Sequential oligonucleotide syntheses using immunoaffinity techniques
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使用免疫亲和技术的顺序寡核苷酸合成
- 专利标题: Sequential oligonucleotide syntheses using immunoaffinity techniques
- 专利标题(中): 使用免疫亲和技术的顺序寡核苷酸合成
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申请号: US18100申请日: 1993-02-17
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公开(公告)号: US5464759A公开(公告)日: 1995-11-07
- 发明人: Thomas R. Coolidge , William Lewis , Sheldon M. Schuster , Jay Stout , Gino van Heeke , Dwane Wylie , Fred W. Wagner
- 申请人: Thomas R. Coolidge , William Lewis , Sheldon M. Schuster , Jay Stout , Gino van Heeke , Dwane Wylie , Fred W. Wagner
- 申请人地址: NE Lincoln NE Lincoln
- 专利权人: BioNebraska, Inc.,Board of Regents of the University of Nebraska
- 当前专利权人: BioNebraska, Inc.,Board of Regents of the University of Nebraska
- 当前专利权人地址: NE Lincoln NE Lincoln
- 主分类号: A61K39/395
- IPC分类号: A61K39/395 ; A61K48/00 ; C07H21/04 ; C07K1/00 ; C07K1/02 ; C07K1/04 ; C07K1/06 ; C07K1/113 ; C07K1/22 ; C07K14/42 ; C07K14/575 ; C07K14/655 ; C07K16/00 ; C12N15/20 ; C12P19/34 ; C12Q1/68
摘要:
The invention is directed to a method of purifying sequentially synthesized peptides and oligonucleotides by affinity techniques. Selected products are capped with and N-terminus capping agent for peptides or a 5'-terminus capping agents for oligonucleotides, and then bound with affinity agents that are selective for the corresponding capping agents.
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