发明授权
- 专利标题: Three dimensional cell and tissue culture system
- 专利标题(中): 三维细胞和组织培养系统
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申请号: US241259申请日: 1994-05-11
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公开(公告)号: US5510254A公开(公告)日: 1996-04-23
- 发明人: Brian A. Naughton , Gail K. Naughton
- 申请人: Brian A. Naughton , Gail K. Naughton
- 申请人地址: CA La Jolla
- 专利权人: Advanced Tissue Sciences, Inc.
- 当前专利权人: Advanced Tissue Sciences, Inc.
- 当前专利权人地址: CA La Jolla
- 主分类号: A61B10/00
- IPC分类号: A61B10/00 ; A61B10/02 ; A61B19/00 ; A61K35/12 ; A61K35/28 ; A61L27/38 ; A61L27/60 ; C12N5/00 ; C12N5/071 ; C12N5/077 ; C12N5/0789 ; C12M3/00
摘要:
The present invention relates to a three-dimensional cell and tissue culture system. In particular, it relates to this culture system for the long term culture of liver cells and tissues in vitro in an environment that more closely approximates that found in vivo. The culture system described herein provides for proliferation and appropriate liver cell maturation to form structures analogous to tissue counterparts in vivo. The resulting liver tissues survive for prolonged periods, perform liver-specific functions, and maintain hepatic tissue architecture following in vivo implantation. The liver cultures have a variety of applications ranging from transplantation or implantation in vivo, to screening cytotoxic compounds and pharmaceutical compounds in vitro, to the production of biologically active molecules in "bioreactors" and to the construction of extracorporeal liver assist device.
公开/授权文献
- US4354392A Rotary kiln material sampling system 公开/授权日:1982-10-19