发明授权
- 专利标题： Glial cell line-derived neurotrophic factor antibody
- 专利标题（中）： 胶质细胞系衍生的神经营养因子抗体
-
申请号： US452242申请日： 1995-05-26
-
公开(公告)号： US5935795A公开(公告)日： 1999-08-10
- 发明人: Leu-Fen H. Lin , Franklin D. Collins , Daniel H. Doherty , Jack Lile , Susan Bektesh
- 申请人： Leu-Fen H. Lin , Franklin D. Collins , Daniel H. Doherty , Jack Lile , Susan Bektesh
- 申请人地址： CA Thousand Oaks
- 专利权人： Amgen Inc.
- 当前专利权人： Amgen Inc.
- 当前专利权人地址： CA Thousand Oaks
- 主分类号： A61K38/00
- IPC分类号： A61K38/00 ; A61K9/00 ; A61K9/22 ; A61K31/00 ; A61K39/395 ; A61M37/00 ; A61P25/00 ; A61P25/16 ; A61P25/26 ; A61P25/28 ; C07H15/12 ; C07K20060101 ; C07K1/20 ; C07K1/22 ; C07K14/47 ; C07K14/475 ; C07K14/52 ; C07K16/00 ; C07K16/24 ; C12N20060101 ; C12N1/21 ; C12N1/22 ; C12N5/02 ; C12N5/06 ; C12N5/08 ; C12N5/10 ; C12N15/09 ; C12N15/12 ; C12P21/02 ; C12P21/06 ; C12P21/08 ; C12R1/19 ; C12R1/91 ; C07K16/22 ; C12N5/12 ; G01N33/53
摘要：
A novel neurotrophic factor referred to as glial cell line-derived neurotrophic factor (GDNF) has been identified and isolated from serum free growth conditioned medium of B49 glioblastoma cells. Rat and human genes encoding GDNF have been cloned and sequenced. A gene encoding GDNF has been subcloned into a vector and the vector has been used to transform a host cell in order to produce biologically active GDNF in a recombinant DNA process. Antibodies to GDNF are disclosed, as well as methods for identifying members of the GDNF family of neurotrophic factors.
公开/授权文献
- US4574451A Method for producing an article with a fluid passage 公开/授权日：1986-03-11
信息查询
IPC分类:
